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Review
. 2020 Sep 17:11:564925.
doi: 10.3389/fimmu.2020.564925. eCollection 2020.

Immunopathogenesis of COVID-19: Summary and Possible Interventions

Francois Henri Jacques  1 , Erik Apedaile  1
Affiliations
Review

Immunopathogenesis of COVID-19: Summary and Possible Interventions

Francois Henri Jacques et al. Front Immunol. .

Abstract

Since the onset of the COVID-19 pandemic in the fall of 2019 over 4 million people have been infected and over 280,000 have died (1). Information about the SARS-CoV2 virus is evolving rapidly. At this time there are no interventions proven to be effective for cases infected with SARS-CoV2. Current knowledge about the clinical and laboratory manifestations of COVID-19 infection is reviewed and combined with knowledge about the immunopathogenic mechanisms of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV1) and Middle East Respiratory Syndrome (MERS) to formulate theories and suggest possible therapeutic interventions. SARS-CoV2 immunopathogenic mechanisms vary from immunosuppression that initially enables viral escape to a hyperinflammatory immune response. Ultimately therapeutic intervention will be phase dependent.

Keywords: COVID-19; hyperinflammation; immunology; immunosuppression; intervention.

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Figures

FIGURE 1
FIGURE 1
COVID 19 Links between immunosuppression and hyperinflammation.
See this image and copyright information in PMC

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