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Review
. 2020 Sep 24:8:526969.
doi: 10.3389/fped.2020.526969. eCollection 2020.

Cardiovascular Involvement in Kawasaki Disease Is Much More Than Mere Coronary Arteritis

Rakesh Kumar Pilania  1 , Ankur Kumar Jindal  1 , Dharmagat Bhattarai  1 , Sanjeev Hanumantacharya Naganur  2 , Surjit Singh  1
Affiliations
Review

Cardiovascular Involvement in Kawasaki Disease Is Much More Than Mere Coronary Arteritis

Rakesh Kumar Pilania et al. Front Pediatr. .

Abstract

Kawasaki disease (KD) is now a common cause of acquired heart disease in children. Coronary artery involvement is the most serious complication in children with KD. Several non-coronary complications have now been identified in this condition but these are often overlooked. Myocarditis is an integral component of KD and may be more common than coronary artery abnormalities. Pericardial involvement and valvular abnormalities have also been observed in patients with KD. KD shock syndrome is now being increasingly recognized and may be difficult to differentiate clinically from toxic shock syndrome. Endothelial dysfunction has been reported both during acute stage and also on follow-up. This may be a potentially modifiable cardiovascular risk factor.

Keywords: Kawasaki disease; Kawasaki disease shock syndrome; cardiac biomarkers; echocardiography; myocarditis; pericarditis.

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Figures

Figure 1
Figure 1
Echocardiography findings in patients with Kawasaki disease.
See this image and copyright information in PMC

References

    1. McCrindle BW, Rowley AH, Newburger JW, Burns JC, Bolger AF, Gewitz M, et al. . Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association. Circulation. (2017) 135:e927–9. 10.1161/CIR.0000000000000484 - DOI - PubMed
    1. Singh S, Jindal AK, Pilania RK. Diagnosis of Kawasaki disease. Int J Rheum Dis. (2018) 21:36–44. 10.1111/1756-185X.13224 - DOI - PMC - PubMed
    1. Kawasaki T. Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children. Arerugi Allergy. (1967) 16:178–222. - PubMed
    1. Fujiwara H, Hamashima Y. Pathology of the heart in Kawasaki disease. Pediatrics. (1978) 61:100–7. - PubMed
    1. Kato H. Cardiovascular complications in Kawasaki disease: coronary artery lumen and long-term consequences. Prog Pediatr Cardiol. (2004) 19:137–45. 10.1016/j.ppedcard.2004.08.007 - DOI

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