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Review
. 2019 Feb 12;5(1):15.
doi: 10.3390/ijns5010015. eCollection 2019 Mar.

Newborn Screening for Sickle Cell Disease in Europe

Yvonne Daniel  1 , Jacques Elion  2 , Bichr Allaf  3 , Catherine Badens  4 , Marelle J Bouva  5 , Ian Brincat  6 , Elena Cela  7 , Cathy Coppinger  1 , Mariane de Montalembert  8 , Béatrice Gulbis  9 , Joan Henthorn  1 , Olivier Ketelslegers  10 , Corrina McMahon  11 , Allison Streetly  12   13 , Raffaella Colombatti  14 , Stephan Lobitz  15
Affiliations
Review

Newborn Screening for Sickle Cell Disease in Europe

Yvonne Daniel et al. Int J Neonatal Screen. .

Abstract

The history of newborn screening (NBS) for sickle cell disease (SCD) in Europe goes back almost 40 years. However, most European countries have not established it to date. The European screening map is surprisingly heterogenous. The first countries to introduce sickle cell screening on a national scale were France and England. The French West Indies started to screen their newborns for SCD as early as 1983/84. To this day, all countries of the United Kingdom of Great Britain and Northern Ireland have added SCD as a target disease to their NBS programs. The Netherlands, Spain and Malta also have national programs. Belgium screens regionally in the Brussels and Liège regions, Ireland has been running a pilot for many years that has become quasi-official. However, the Belgian and Irish programs are not publicly funded. Italy and Germany have completed several pilot studies but are still in the preparatory phase of national NBS programs for SCD, although both countries have well-established concepts for metabolic and endocrine disorders. This article will give a brief overview of the situation in Europe and put a focus on the programs of the two pioneers of the continent, England and France.

Keywords: newborn; screening; sickle cell disease.

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Conflict of interest statement

Conflicts of InterestThe authors declare no conflict of interest.

References

    1. National Sickle Cell Anemia Control Act. [(accessed on 9 February 2019)]; Available online: https://www.govinfo.gov/content/pkg/STATUTE-86/pdf/STATUTE-86-Pg136-2.pdf.
    1. Gaston M.H., Verter J.I., Woods G., Pegelow C., Kelleher J., Presbury G., Zarkowsky H., Vichinsky E., Iyer R., Lobel J.S., et al. Prophylaxis with oral penicillin in children with sickle cell anemia. A randomized trial. N. Engl. J. Med. 1986;314:1593–1599. doi: 10.1056/NEJM198606193142501. - DOI - PubMed
    1. Zeuner D., Ades A.E., Karnon J., Brown J., Dezateux C., Anionwu E.N. Antenatal and neonatal haemoglobinopathy screening in the UK: Review and economic analysis. Health Technol. Assess. 1999;3:1–186. - PubMed
    1. The NHS Plan: A Plan for Investment, A Plan for Reform. Department of Health; London, UK: 2000.
    1. Moat S.J., Rees D., King L., Ifederu A., Harvey K., Hall K., Lloyd G., Morrell C., Hillier S. Newborn blood spot screening for sickle cell disease by using tandem mass spectrometry: Implementation of a protocol to identify only the disease states of sickle cell disease. Clin. Chem. 2014;60:373–380. doi: 10.1373/clinchem.2013.210948. - DOI - PubMed