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Review
. 2020 Jan 31;6(1):8.
doi: 10.3390/ijns6010008. eCollection 2020 Mar.

History of Newborn Screening for Cystic Fibrosis-The Early Years

Georges Travert  1   2 , Mary Heeley  3 , Anthony Heeley  3
Affiliations
Review

History of Newborn Screening for Cystic Fibrosis-The Early Years

Georges Travert et al. Int J Neonatal Screen. .

Abstract

This review summarises the trajectory of neonatal screening strategies for the detection of cystic fibrosis (CF) using the measurement of Immunoreactive Trypsin (IRT) in dried blood spots (DBS) from 1979 until the beginning of the 21st century when newborn screening (NBS) programmes started to spread throughout many countries, using IRT measurement combined with a CF genotype analysis of DBS.

Keywords: DNA; dried blood spot; immunoreactive trypsin(ogen); newborn screening; radioimmunoassay.

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Conflict of interest statement

Conflicts of InterestThe authors declare no conflict of interest.

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