Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Dec;177(24):5677-5678.
doi: 10.1111/bph.15264. Epub 2020 Oct 18.

Is the C3a receptor antagonist SB290157 a useful pharmacological tool?

Affiliations
Comment

Is the C3a receptor antagonist SB290157 a useful pharmacological tool?

John D Lee et al. Br J Pharmacol. 2020 Dec.
No abstract available

PubMed Disclaimer

Comment on

References

    1. Ahmad, S. , Pandya, C. , Kindelin, A. , Bhatia, K. , Chaudhary, R. , Dwivedi, A. K. , … Ducruet, A. F. (2020). C3a receptor antagonist therapy is protective with or without thrombolysis in murine thromboembolic stroke. British Journal of Pharmacology, 177, 2466–2477. 10.1111/bph.14989 - DOI - PMC - PubMed
    1. Busche, M. N. , & Stahl, G. L. (2010). Role of the complement components C5 and C3a in a mouse model of myocardial ischemia and reperfusion injury. German Medical Science, 8, Doc20. - PMC - PubMed
    1. Coulthard, L. G. , & Woodruff, T. M. (2015). Is the complement activation product C3a a proinflammatory molecule? Re‐evaluating the evidence and the myth. Journal of Immunology, 194, 3542–3548. - PubMed
    1. Li, X. X. , Lee, J. D. , Kumar, V. , & Woodruff, T. M. (2020). The ‘C3aR antagonist’ SB290157 is a partial C5aR2 agonist. bioRxiv 10.1101/2020.08.01.232090. - DOI - PMC - PubMed
    1. Mathieu, M. C. , Sawyer, N. , Greig, G. M. , Hamel, M. , Kargman, S. , Ducharme, Y. , … Therien, A. G. (2005). The C3a receptor antagonist SB 290157 has agonist activity. Immunology Letters, 100, 139–145. 10.1016/j.imlet.2005.03.003 - DOI - PubMed