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. 2021 Mar;93(3):1810-1813.
doi: 10.1002/jmv.26609. Epub 2020 Nov 10.

Passive immunity in newborn from SARS-CoV-2-infected mother

Anna F Cavaliere  1 , Laura Marchi  1 , Donatella Aquilini  2 , Tamara Brunelli  3 , Pier L Vasarri  4
Affiliations

Passive immunity in newborn from SARS-CoV-2-infected mother

Anna F Cavaliere et al. J Med Virol. 2021 Mar.

Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vertical transmission is an open issue. Recent reports call into question in utero or peripartum viral transmission to the offspring. Few data are available on immunoglobulin G (IgG) and/or IgM in newborns. Insufficient evidence is available regarding passive immunity in neonates born from SARS-CoV-2 infected women. We report a case of a neonate showing the presence of blood specific IgG and the absence of IgM and negative nasopharyngeal swab. He was born from an asymptomatic SARS-CoV-2-infected mother with positive IgG and IgM. The transplacental passage of specific IgG antibodies from the affected mother to the unaffected fetus highlights neonatal passive immunity.

Keywords: SARS-CoV-2; coronavirus; passive immunity; vertical transmission.

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References

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