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Review
. 2021 Jan;21(1):e2000280.
doi: 10.1002/mabi.202000280. Epub 2020 Oct 19.

Bioprinting of Collagen: Considerations, Potentials, and Applications

Jia Min Lee  1 , Sean Kang Qiang Suen  1 , Wei Long Ng  2 , Wai Cheung Ma  1 , Wai Yee Yeong  1   2
Affiliations
Review

Bioprinting of Collagen: Considerations, Potentials, and Applications

Jia Min Lee et al. Macromol Biosci. 2021 Jan.

Abstract

Collagen is the most abundant extracellular matrix protein that is widely used in tissue engineering (TE). There is little research done on printing pure collagen. To understand the bottlenecks in printing pure collagen, it is imperative to understand collagen from a bottom-up approach. Here it is aimed to provide a comprehensive overview of collagen printing, where collagen assembly in vivo and the various sources of collagen available for TE application are first understood. Next, the current printing technologies and strategy for printing collagen-based materials are highlighted. Considerations and key challenges faced in collagen printing are identified. Finally, the key research areas that would enhance the functionality of printed collagen are presented.

Keywords: 3D bioprinting; 3D printing; additive manufacturing; biofabrication; collagen hydrogel; tissue engineering.

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