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. 2022 Jun;64(2):244-252.
doi: 10.23736/S0031-0808.20.04168-3. Epub 2020 Oct 19.

Biobanking for COVID-19 research

Patrizia Rovere-Querini  1   2 , Cristina Tresoldi  3 , Caterina Conte  4 , Annalisa Ruggeri  4 , Silvia Ghezzi  4 , Rebecca DE Lorenzo  5 , Luigi DI Filippo  5 , Nicola Farina  5 , Giuseppe A Ramirez  5   4 , Marco Ripa  5   4 , Nicasio Mancini  5   6 , Elisa Cantarelli  7 , Laura Galli  4 , Andrea Poli  4 , Francesco DE Cobelli  5   8 , Chiara Bonini  5   4 , Angelo A Manfredi  5   4 , Stefano Franchini  9 , Marzia Spessot  9 , Michele Carlucci  9 , Lorenzo Dagna  5   10 , Paolo Scarpellini  4 , Alberto Ambrosio  11 , Davide DI Napoli  11 , Emanuele Bosi  5   4 , Moreno Tresoldi  12 , Adriano Lazzarin  5   4 , Giovanni Landoni  5   13 , Gianvito Martino  5   14 , Alberto Zangrillo  5   13 , Guido Poli  5   4 , Antonella Castagna  5   4 , Elisa Vicenzi  4 , Massimo Clementi  5   6 , Fabio Ciceri  5   4 ; COVID-BioB Study Group
Collaborators, Affiliations

Biobanking for COVID-19 research

Patrizia Rovere-Querini et al. Panminerva Med. 2022 Jun.

Abstract

Background: Biobanks are imperative infrastructures, particularly during outbreaks, when there is an obligation to acquire and share knowledge as quick as possible to allow for implementation of science-based preventive, diagnostic, prognostic, and therapeutic strategies.

Methods: We established a COVID-19 biobank with the aim of collecting high-quality and well-annotated human biospecimens, in the effort to understand the pathogenic mechanisms underlying COVID-19 and identify therapeutic targets (COVID-BioB, NCT04318366). Here we describe our experience and briefly review the characteristics of the biobanks for COVID-19 that have been so far established.

Results: A total of 46,677 samples have been collected from 913 participants (63.3% males, median [IQR] age 62.2 [51.2-74.0] years) since the beginning of the program. Most patients (66.9%) had been admitted to hospital for COVID-19, with a median length of stay of 15.0 (9.0-27.0) days. A minority of patients (13.3% of the total) had been admitted for other reasons and subsequently tested positive for SARS-CoV-2. The remainder were managed at home after being seen at the Emergency Department.

Conclusions: Having a solid research infrastructure already in place, along with flexibility and adaptability to new requirements, allowed for the quick building of a COVID-19 biobank that will help expand and share the knowledge of SARS-CoV-2.

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