Biological functions of long noncoding RNAs and circular RNAs in small-cell lung cancer
- PMID: 33074037
- DOI: 10.2217/epi-2020-0214
Biological functions of long noncoding RNAs and circular RNAs in small-cell lung cancer
Abstract
We aim to discuss comprehensively the role of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in small-cell lung cancer (SCLC) biology and their clinical utility as cancer biomarkers. We searched the scientific literature to select articles related to the role of lncRNAs and circRNAs in SCLC biology or as cancer biomarkers. We identified that a number of lncRNAs and circRNAs can regulate key biological processes involved in SCLC development, including cell proliferation, metastasis and chemoresistance mainly acting as miRNA sponges. Also, the expression of a few lncRNAs and circRNAs predicted survival outcome depicting their utility as prognostic biomarkers. Further investigations on the role of lncRNAs and circRNAs in SCLC tumors may yield novel therapeutic targets for SCLC.
Keywords: biomarker; chemoresistance; circular RNA; diagnosis; long noncoding RNA; metastasis; prognosis; small-cell lung cancer.
Similar articles
-
Role of microRNAs in regulating cell proliferation, metastasis and chemoresistance and their applications as cancer biomarkers in small cell lung cancer.Biochim Biophys Acta Rev Cancer. 2021 Aug;1876(1):188552. doi: 10.1016/j.bbcan.2021.188552. Epub 2021 Apr 21. Biochim Biophys Acta Rev Cancer. 2021. PMID: 33892053 Review.
-
Roles of Long Noncoding RNAs and Circular RNAs in Translation.Cold Spring Harb Perspect Biol. 2019 Jun 3;11(6):a032680. doi: 10.1101/cshperspect.a032680. Cold Spring Harb Perspect Biol. 2019. PMID: 30082465 Free PMC article. Review.
-
Long Noncoding RNAs and Circular RNAs in the Metabolic Reprogramming of Lung Cancer: Functions, Mechanisms, and Clinical Potential.Oxid Med Cell Longev. 2022 Jun 15;2022:4802338. doi: 10.1155/2022/4802338. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 35757505 Free PMC article. Review.
-
Long non-coding RNA HOTTIP promotes BCL-2 expression and induces chemoresistance in small cell lung cancer by sponging miR-216a.Cell Death Dis. 2018 Jan 24;9(2):85. doi: 10.1038/s41419-017-0113-5. Cell Death Dis. 2018. PMID: 29367594 Free PMC article.
-
Progress in research on the role of circular RNAs in lung cancer.World J Surg Oncol. 2018 Nov 6;16(1):215. doi: 10.1186/s12957-018-1515-2. World J Surg Oncol. 2018. PMID: 30400981 Free PMC article. Review.
Cited by
-
Identification of key genes and pathway related to chemoresistance of small cell lung cancer through an integrative bioinformatics analysis.Ann Transl Med. 2022 Sep;10(18):968. doi: 10.21037/atm-22-3642. Ann Transl Med. 2022. PMID: 36267705 Free PMC article.
-
FAK-LINC01089 negative regulatory loop controls chemoresistance and progression of small cell lung cancer.Oncogene. 2024 May;43(22):1669-1687. doi: 10.1038/s41388-024-03027-y. Epub 2024 Apr 9. Oncogene. 2024. PMID: 38594505
-
Circ_001209 aggravates diabetic retinal vascular dysfunction through regulating miR-15b-5p/COL12A1.J Transl Med. 2021 Jul 7;19(1):294. doi: 10.1186/s12967-021-02949-5. J Transl Med. 2021. PMID: 34233716 Free PMC article.
-
Multi-Omics Integration-Based Prioritisation of Competing Endogenous RNA Regulation Networks in Small Cell Lung Cancer: Molecular Characteristics and Drug Candidates.Front Oncol. 2022 Jul 4;12:904865. doi: 10.3389/fonc.2022.904865. eCollection 2022. Front Oncol. 2022. PMID: 35860558 Free PMC article.
-
Long noncoding RNA MEG3: an active player in fibrosis.Pharmacol Rep. 2025 Feb;77(1):21-30. doi: 10.1007/s43440-024-00661-x. Epub 2024 Oct 7. Pharmacol Rep. 2025. PMID: 39373865 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
