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. 2020 Nov 6;22(21):8613-8617.
doi: 10.1021/acs.orglett.0c03185. Epub 2020 Oct 19.

Synthetic Investigation toward QS-21 Analogues

Zhi-Yong Zeng  1 , Jin-Xi Liao  1 , Zhen-Ni Hu  1 , De-Yong Liu  1 , Qing-Ju Zhang  1 , Jian-Song Sun  1
Affiliations

Synthetic Investigation toward QS-21 Analogues

Zhi-Yong Zeng et al. Org Lett. .

Abstract

With glycosyl o-alkynylbenzotes as donors, a highly efficient protocol to construct the challenging glycosidic linkages at C3-OH of C23-oxo oleanane triterpenoids is disclosed, on the basis of which different strategies for the highly efficient synthesis of QS-21 analogues with the west-wing trisaccharide of QS-21 have been established.

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