doi: 10.1002/14651858.CD012859.pub2.
Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis
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- PMID: 33075160
- PMCID: PMC8094506
- DOI: 10.1002/14651858.CD012859.pub2
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Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis
Cochrane Database Syst Rev.
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Abstract
Background: Postoperative nausea and vomiting (PONV) is a common adverse effect of anaesthesia and surgery. Up to 80% of patients may be affected. These outcomes are a major cause of patient dissatisfaction and may lead to prolonged hospital stay and higher costs of care along with more severe complications. Many antiemetic drugs are available for prophylaxis. They have various mechanisms of action and side effects, but there is still uncertainty about which drugs are most effective with the fewest side effects.
Objectives: • To compare the efficacy and safety of different prophylactic pharmacologic interventions (antiemetic drugs) against no treatment, against placebo, or against each other (as monotherapy or combination prophylaxis) for prevention of postoperative nausea and vomiting in adults undergoing any type of surgery under general anaesthesia • To generate a clinically useful ranking of antiemetic drugs (monotherapy and combination prophylaxis) based on efficacy and safety • To identify the best dose or dose range of antiemetic drugs in terms of efficacy and safety SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), the World Health Organization International Clinical Trials Registry Platform (WHO ICTRP), ClinicalTrials.gov, and reference lists of relevant systematic reviews. The first search was performed in November 2017 and was updated in April 2020. In the update of the search, 39 eligible studies were found that were not included in the analysis (listed as awaiting classification).
Selection criteria: Randomized controlled trials (RCTs) comparing effectiveness or side effects of single antiemetic drugs in any dose or combination against each other or against an inactive control in adults undergoing any type of surgery under general anaesthesia. All antiemetic drugs belonged to one of the following substance classes: 5-HT₃ receptor antagonists, D₂ receptor antagonists, NK₁ receptor antagonists, corticosteroids, antihistamines, and anticholinergics. No language restrictions were applied. Abstract publications were excluded.
Data collection and analysis: A review team of 11 authors independently assessed trials for inclusion and risk of bias and subsequently extracted data. We performed pair-wise meta-analyses for drugs of direct interest (amisulpride, aprepitant, casopitant, dexamethasone, dimenhydrinate, dolasetron, droperidol, fosaprepitant, granisetron, haloperidol, meclizine, methylprednisolone, metoclopramide, ondansetron, palonosetron, perphenazine, promethazine, ramosetron, rolapitant, scopolamine, and tropisetron) compared to placebo (inactive control). We performed network meta-analyses (NMAs) to estimate the relative effects and ranking (with placebo as reference) of all available single drugs and combinations. Primary outcomes were vomiting within 24 hours postoperatively, serious adverse events (SAEs), and any adverse event (AE). Secondary outcomes were drug class-specific side effects (e.g. headache), mortality, early and late vomiting, nausea, and complete response. We performed subgroup network meta-analysis with dose of drugs as a moderator variable using dose ranges based on previous consensus recommendations. We assessed certainty of evidence of NMA treatment effects for all primary outcomes and drug class-specific side effects according to GRADE (CINeMA, Confidence in Network Meta-Analysis). We restricted GRADE assessment to single drugs of direct interest compared to placebo.
Main results: We included 585 studies (97,516 randomized participants). Most of these studies were small (median sample size of 100); they were published between 1965 and 2017 and were primarily conducted in Asia (51%), Europe (25%), and North America (16%). Mean age of the overall population was 42 years. Most participants were women (83%), had American Society of Anesthesiologists (ASA) physical status I and II (70%), received perioperative opioids (88%), and underwent gynaecologic (32%) or gastrointestinal surgery (19%) under general anaesthesia using volatile anaesthetics (88%). In this review, 44 single drugs and 51 drug combinations were compared. Most studies investigated only single drugs (72%) and included an inactive control arm (66%). The three most investigated single drugs in this review were ondansetron (246 studies), dexamethasone (120 studies), and droperidol (97 studies). Almost all studies (89%) reported at least one efficacy outcome relevant for this review. However, only 56% reported at least one relevant safety outcome. Altogether, 157 studies (27%) were assessed as having overall low risk of bias, 101 studies (17%) overall high risk of bias, and 327 studies (56%) overall unclear risk of bias. Vomiting within 24 hours postoperatively Relative effects from NMA for vomiting within 24 hours (282 RCTs, 50,812 participants, 28 single drugs, and 36 drug combinations) suggest that 29 out of 36 drug combinations and 10 out of 28 single drugs showed a clinically important benefit (defined as the upper end of the 95% confidence interval (CI) below a risk ratio (RR) of 0.8) compared to placebo. Combinations of drugs were generally more effective than single drugs in preventing vomiting. However, single NK₁ receptor antagonists showed treatment effects similar to most of the drug combinations. High-certainty evidence suggests that the following single drugs reduce vomiting (ordered by decreasing efficacy): aprepitant (RR 0.26, 95% CI 0.18 to 0.38, high certainty, rank 3/28 of single drugs); ramosetron (RR 0.44, 95% CI 0.32 to 0.59, high certainty, rank 5/28); granisetron (RR 0.45, 95% CI 0.38 to 0.54, high certainty, rank 6/28); dexamethasone (RR 0.51, 95% CI 0.44 to 0.57, high certainty, rank 8/28); and ondansetron (RR 0.55, 95% CI 0.51 to 0.60, high certainty, rank 13/28). Moderate-certainty evidence suggests that the following single drugs probably reduce vomiting: fosaprepitant (RR 0.06, 95% CI 0.02 to 0.21, moderate certainty, rank 1/28) and droperidol (RR 0.61, 95% CI 0.54 to 0.69, moderate certainty, rank 20/28). Recommended and high doses of granisetron, dexamethasone, ondansetron, and droperidol showed clinically important benefit, but low doses showed no clinically important benefit. Aprepitant was used mainly at high doses, ramosetron at recommended doses, and fosaprepitant at doses of 150 mg (with no dose recommendation available). Frequency of SAEs Twenty-eight RCTs were included in the NMA for SAEs (10,766 participants, 13 single drugs, and eight drug combinations). The certainty of evidence for SAEs when using one of the best and most reliable anti-vomiting drugs (aprepitant, ramosetron, granisetron, dexamethasone, ondansetron, and droperidol compared to placebo) ranged from very low to low. Droperidol (RR 0.88, 95% CI 0.08 to 9.71, low certainty, rank 6/13) may reduce SAEs. We are uncertain about the effects of aprepitant (RR 1.39, 95% CI 0.26 to 7.36, very low certainty, rank 11/13), ramosetron (RR 0.89, 95% CI 0.05 to 15.74, very low certainty, rank 7/13), granisetron (RR 1.21, 95% CI 0.11 to 13.15, very low certainty, rank 10/13), dexamethasone (RR 1.16, 95% CI 0.28 to 4.85, very low certainty, rank 9/13), and ondansetron (RR 1.62, 95% CI 0.32 to 8.10, very low certainty, rank 12/13). No studies reporting SAEs were available for fosaprepitant. Frequency of any AE Sixty-one RCTs were included in the NMA for any AE (19,423 participants, 15 single drugs, and 11 drug combinations). The certainty of evidence for any AE when using one of the best and most reliable anti-vomiting drugs (aprepitant, ramosetron, granisetron, dexamethasone, ondansetron, and droperidol compared to placebo) ranged from very low to moderate. Granisetron (RR 0.92, 95% CI 0.80 to 1.05, moderate certainty, rank 7/15) probably has no or little effect on any AE. Dexamethasone (RR 0.77, 95% CI 0.55 to 1.08, low certainty, rank 2/15) and droperidol (RR 0.89, 95% CI 0.81 to 0.98, low certainty, rank 6/15) may reduce any AE. Ondansetron (RR 0.95, 95% CI 0.88 to 1.01, low certainty, rank 9/15) may have little or no effect on any AE. We are uncertain about the effects of aprepitant (RR 0.87, 95% CI 0.78 to 0.97, very low certainty, rank 3/15) and ramosetron (RR 1.00, 95% CI 0.65 to 1.54, very low certainty, rank 11/15) on any AE. No studies reporting any AE were available for fosaprepitant. Class-specific side effects For class-specific side effects (headache, constipation, wound infection, extrapyramidal symptoms, sedation, arrhythmia, and QT prolongation) of relevant substances, the certainty of evidence for the best and most reliable anti-vomiting drugs mostly ranged from very low to low. Exceptions were that ondansetron probably increases headache (RR 1.16, 95% CI 1.06 to 1.28, moderate certainty, rank 18/23) and probably reduces sedation (RR 0.87, 95% CI 0.79 to 0.96, moderate certainty, rank 5/24) compared to placebo. The latter effect is limited to recommended and high doses of ondansetron. Droperidol probably reduces headache (RR 0.76, 95% CI 0.67 to 0.86, moderate certainty, rank 5/23) compared to placebo. We have high-certainty evidence that dexamethasone (RR 1.00, 95% CI 0.91 to 1.09, high certainty, rank 16/24) has no effect on sedation compared to placebo. No studies assessed substance class-specific side effects for fosaprepitant. Direction and magnitude of network effect estimates together with level of evidence certainty are graphically summarized for all pre-defined GRADE-relevant outcomes and all drugs of direct interest compared to placebo in http://doi.org/10.5281/zenodo.4066353.
Authors' conclusions: We found high-certainty evidence that five single drugs (aprepitant, ramosetron, granisetron, dexamethasone, and ondansetron) reduce vomiting, and moderate-certainty evidence that two other single drugs (fosaprepitant and droperidol) probably reduce vomiting, compared to placebo. Four of the six substance classes (5-HT₃ receptor antagonists, D₂ receptor antagonists, NK₁ receptor antagonists, and corticosteroids) were thus represented by at least one drug with important benefit for prevention of vomiting. Combinations of drugs were generally more effective than the corresponding single drugs in preventing vomiting. NK₁ receptor antagonists were the most effective drug class and had comparable efficacy to most of the drug combinations. 5-HT₃ receptor antagonists were the best studied substance class. For most of the single drugs of direct interest, we found only very low to low certainty evidence for safety outcomes such as occurrence of SAEs, any AE, and substance class-specific side effects. Recommended and high doses of granisetron, dexamethasone, ondansetron, and droperidol were more effective than low doses for prevention of vomiting. Dose dependency of side effects was rarely found due to the limited number of studies, except for the less sedating effect of recommended and high doses of ondansetron. The results of the review are transferable mainly to patients at higher risk of nausea and vomiting (i.e. healthy women undergoing inhalational anaesthesia and receiving perioperative opioids). Overall study quality was limited, but certainty assessments of effect estimates consider this limitation. No further efficacy studies are needed as there is evidence of moderate to high certainty for seven single drugs with relevant benefit for prevention of vomiting. However, additional studies are needed to investigate potential side effects of these drugs and to examine higher-risk patient populations (e.g. individuals with diabetes and heart disease).
Copyright © 2020 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Conflict of interest statement
General note: our review team included several experts in the field (NLP, DR, MSS, PKi, LHJE, AH, TS, PKr). Review authors (LHJE, PKr) who were involved in the conduct of studies related to the current review did not assess the relevant studies for inclusion or exclusion and were not allowed to extract data or critically appraise the quality of the relevant studies.
Stephanie Weibel has no conflict of interest regarding the topic of this review. Stephanie Weibel is an academic researcher. She has received personal payments for consultancies and lecture fees from Genelux Corporation, San Diego, California, USA (ended March 2014). Genelux Corporation does not produce any products for the intervention of interest in this review. She was involved in the conduct of phase 3 clinical trials related to the current review (“Amisulpride (APD421)” (NCT02646566NCT02449291Kranke 2018), and she was involved in a meta‐analysis on the incidence of postoperative nausea and vomiting that was published recently (Schaefer 2016). She received funding through a one‐time payment from B. Braun‐Stiftung, Melsungen, Germany. The B. Braun‐Stiftung is an independent and non‐profit foundation. She has received lecture fees (topic: systematic reviews and meta‐analyses) from the University of Marburg (2017, 2020).
Gerta Rücker is employed as a statistician at the Institute of Medical Biometry and Statistics of the Medical Center at the University of Freiburg. She received payment for a one‐day course on statistical methods in meta‐analysis from the Grünenthal Group, Aachen, Germany.
Nathan L Pace has no conflict of interest regarding the topic of this review. Nathan L Pace is a non‐practising anaesthetist and statistician faculty member of the University of Utah, receives no private practice income, and has no commercial relationships. He has received payment for development of educational presentations (Barash, Cullen, Stoelting, CLINICAL ANESTHESIA, 8th edition) and has provided consultancy (St Marks Hospital, Salt Lake City, Utah, USA) on topics unrelated to the current review. He has received supplements to attend Cochrane meetings. He also has stocks and shares in companies that have no interest in the topic of this review (TIAA‐CREF, Fidelity, Vanguard, USAA, MorganStanley).
Leopold Eberhart is employed as a clinical and academic anaesthetist with a clinical and research focus on postoperative pain management and postoperative nausea and vomiting. He has no conflict of interest regarding the topic of this review. Leopold Eberhart has received lecture fees (from Baxter GmbH and Fresenius GmbH) and payment for lectures (from Gruenenthal GmbH, Baxter GmbH and Fresenius, GmbH) and has provided consultancy (for Gruenenthal GmbH and ratiopharm GmbH) for topics not related to the current review. He holds a board membership with Gruenenthal GmbH Deutschland, which does not have an interest in the topic of this review. He has been involved in the conduct of phase 2 and phase 3 clinical trials related to the current review (“Amisulpride (APD421)” (NCT02646566NCT02449291Kranke 2018Gan 2017Kranke 2013; “Vestipitant (GW597599)” (NCT01507194); “Buspiron” (Kranke 2012); IMPACT study (Apfel 2004)). He was an author of several papers on postoperative nausea and vomiting.
Hannah Hartl has no conflict of interest regarding the topic of this review. Hannah Hartl is a medical student.
Olivia Jordan has no conflict of interest regarding the topic of this review. Olivia Jordan is a medical student.
Debora Mayer has no conflict of interest regarding the topic of this review. Debora Mayer is a medical student.
Manuel Riemer has no conflict of interest regarding the topic of this review. Manuel Riemer is a medical student.
Maximilian S Schaefer has no conflict of interest regarding the topic of this review. Maximilian S Schaefer is an attending anaesthesiologist. He was involved in a meta‐analysis on the incidence of postoperative nausea and vomiting published recently (Schaefer 2016).
Diana Raj has no conflict of interest regarding the topic of this review. Diana Raj is a consultant in clinical anaesthesiology and a Trustee and Secretary of West of Scotland Anaesthetic Teaching (WOSAT), Scottish Charity SC04663.
Insa Linnea Backhaus has no conflict of interest regarding the topic of this review. Insa Linnea Backhaus earned her PhD in Public Health and is an academic researcher.
Antonia Helf has no conflict of interest regarding the topic of this review. Antonia Helf is a clinical investigator and academic researcher. She was involved in the conduct of phase 3 clinical trials related to the current review (“Amisulpride (APD421)” (NCT02646566NCT02449291)).
Tobias Schlesinger has no conflict of interest. Tobias Schlesinger is a clinical investigator and academic researcher.
Peter Kienbaum is employed as a clinical and academic anaesthetist and has been holding the position of vice chairman of the anaesthesia department for 10 years. His clinical and research work focuses on cardiovascular effects of anaesthetics and recovery after anaesthesia. Peter Kienbaum has been consulting for Baxter Germany, Air Liquide Germany, Orion Pharma Germany, and TEVA ratiopharm Germany, with respect to inhaled anaesthetics and other issues not related to this review. He authored several trial papers unrelated to the current review and was involved in a meta‐analysis on the incidence of postoperative nausea and vomiting published recently (Schaefer 2016).
Peter Kranke is employed as a clinical and academic anaesthetist with a clinical and research focus on obstetric anaesthesia and postoperative nausea and vomiting. He has received lecture fees (from MSD, ratiopharm, Covidien) and has provided consultancy (to MSD, Ratiopharm, Covidien) on topics unrelated to the current review. He has received lecture fees and provided consultancy to Fresenius GmbH. This company manufactures propofol, which may be effective as an antiemetic in reducing PONV. He acted as a consultant for Acacia Ltd. He has been involved in the conduct of phase 2 and phase 3 clinical trials related to the current review (“Amisulpride (APD421)” (NCT02646566NCT02449291Kranke 2018Gan 2017Kranke 2013); “Vestipitant (GW597599)” (NCT01507194); “Buspiron” (Kranke 2012); IMPACT study (Apfel 2004)). He was author of several trial papers and of the consensus guidelines for management of postoperative nausea and vomiting. He has published research reports and editorial views on the topic under review and was involved in a meta‐analysis on the incidence of postoperative nausea and vomiting published recently (Schaefer 2016).
Figures
Magnitude‐based inferences to describe effect estimates, CIs, and clinical relevance for efficacy outcomes. The range of equivalence is defined as a risk ratio of 0.8 to 1.25.
Magnitude‐based inferences to describe effect estimates, CIs, and clinical relevance for safety outcomes. The range of equivalence is defined as a risk ratio of 0.9 to 1.11.
Study flow diagram.
Number of annual publications (included studies, n = 585) from 1965 to 2017 (first search).
Risk of bias summary: review authors' judgements about each risk of bias item for each included study. Higher‐resolution image is available online (Supplementary File_Summary of Risk of bias).
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
Direction of network effect estimates (colour code) of single drugs of direct interest compared to placebo with certainty levels of evidence (high, moderate, low, very low) for all GRADE‐relevant, pre‐defined outcomes. Colour code: important benefit (green), uncertain benefit (light green), no important effect (yellow), uncertain minimal (or no) effect (light yellow), uncertain harm (orange), important harm (red), no studies available (NA).
Network geometry of eligible comparisons for postoperative vomiting within 24 hours after surgery. The thickness of the edges is proportionate to the number of included studies comparing two treatments. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Forest plot of network meta‐analysis of all trials for postoperative vomiting within 24 hours after surgery. Single drugs and combinations were compared with placebo (reference compound). RR = risk ratio, 95% CI = 95% confidence interval. RR < 1 favours the intervention, RR > 1 favours placebo. The blue lines indicate the range of equivalence (RR = 0.8 to 1.25). Treatments are ranked according to efficacy based on P scores. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Network geometry of eligible comparisons for serious adverse events (SAE) within 7 days postoperatively. The thickness of the edges is proportionate to the number of included studies comparing two treatments. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Forest plot of network meta‐analysis of all trials for serious adverse events (SAE) within 7 days postoperatively. Single drugs and combinations were compared with placebo (reference compound). RR = risk ratio, 95% CI = 95% confidence interval. RR < 1 favours the intervention, RR > 1 favours placebo. The blue lines indicate the range of equivalence (RR = 0.9 to 1.11). Treatments are ranked according to safety based on P scores. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Network geometry of eligible comparisons for any adverse event (any AE) within 7 days postoperatively. The thickness of the edges is proportionate to the number of included studies comparing two treatments. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Forest plot of network meta‐analysis of all trials for any adverse events (any AE) within 7 days postoperatively. Single drugs and combinations were compared with placebo (reference compound). RR = risk ratio, 95% CI = 95% confidence interval. RR < 1 favours the intervention, RR > 1 favours placebo. The blue lines indicate the range of equivalence (RR = 0.9 to 1.11). Treatments are ranked according to safety based on P scores. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Network geometry of eligible comparisons for postoperative headache. The thickness of the edges is proportionate to the number of included studies comparing two treatments. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Forest plot of network meta‐analysis of all trials for postoperative headache. Single drugs and combinations were compared with placebo (reference compound). RR = risk ratio, 95% CI = 95% confidence interval. RR < 1 favours the intervention, RR > 1 favours placebo. The blue lines indicate the range of equivalence (RR = 0.9 to 1.11). Treatments are ranked according to safety based on P scores. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Network geometry of eligible comparisons for postoperative sedation. The thickness of the edges is proportionate to the number of included studies comparing two treatments. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Forest plot of network meta‐analysis of all trials for postoperative sedation. Single drugs and combinations were compared with placebo (reference compound). RR = risk ratio, 95% CI = 95% confidence interval. RR < 1 favours the intervention, RR > 1 favours placebo. The blue lines indicate the range of equivalence (RR = 0.9 to 1.11). Treatments are ranked according to safety based on P scores. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Network geometry of eligible comparisons for postoperative extrapyramidal symptoms. The thickness of the edges is proportionate to the number of included studies comparing two treatments. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Forest plot of network meta‐analysis of all trials for postoperative extrapyramidal symptoms. Single drugs and combinations were compared with placebo (reference compound). RR = risk ratio, 95% CI = 95% confidence interval. RR < 1 favours the intervention, RR > 1 favours placebo. The blue lines indicate the range of equivalence (RR = 0.9 to 1.11). Treatments are ranked according to safety based on P scores. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Network geometry of eligible comparisons for postoperative constipation. The thickness of the edges is proportionate to the number of included studies comparing two treatments. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Forest plot of network meta‐analysis of all trials for postoperative constipation. Single drugs and combinations were compared with placebo (reference compound). RR = risk ratio, 95% CI = 95% confidence interval. RR < 1 favours the intervention, RR > 1 favours placebo. The blue lines indicate the range of equivalence (RR = 0.9 to 1.11). Treatments are ranked according to safety based on P scores. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Network geometry of eligible comparisons for wound infection within 7 days postoperatively. The thickness of the edges is proportionate to the number of included studies comparing two treatments. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Forest plot of network meta‐analysis of all trials for wound infection within 7 days postoperatively. Single drugs and combinations were compared with placebo (reference compound). RR = risk ratio, 95% CI = 95% confidence interval. RR < 1 favours the intervention, RR > 1 favours placebo. The blue lines indicate the range of equivalence (RR = 0.9 to 1.11). Treatments are ranked according to safety based on P scores. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Network geometry of eligible comparisons for postoperative arrhythmia. The thickness of the edges is proportionate to the number of included studies comparing two treatments. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Forest plot of network meta‐analysis of all trials for postoperative arrhythmia. Single drugs and combinations were compared with placebo (reference compound). RR = risk ratio, 95% CI = 95% confidence interval. RR < 1 favours the intervention, RR > 1 favours placebo. The blue lines indicate the range of equivalence (RR = 0.9 to 1.11). Treatments are ranked according to safety based on P scores. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Network geometry of eligible comparisons for postoperative visual disturbances. The thickness of the edges is proportionate to the number of included studies comparing two treatments. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Forest plot of network meta‐analysis of all trials for postoperative visual disturbances. Single drugs and combinations were compared with placebo (reference compound). RR = risk ratio, 95% CI = 95% confidence interval. RR < 1 favours the intervention, RR > 1 favours placebo. The blue lines indicate the range of equivalence (RR = 0.9 to 1.11). Treatments are ranked according to safety based on P scores. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Network geometry of eligible comparisons for postoperative QT prolongation. The thickness of the edges is proportionate to the number of included studies comparing two treatments. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Forest plot of network meta‐analysis of all trials for postoperative QT prolongation. Single drugs and combinations were compared with placebo (reference compound). RR = risk ratio, 95% CI = 95% confidence interval. RR < 1 favours the intervention, RR > 1 favours placebo. The blue lines indicate the range of equivalence (RR = 0.9 to 1.11). Treatments are ranked according to safety based on P scores. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Network geometry of eligible comparisons for early postoperative vomiting. The thickness of the edges is proportionate to the number of included studies comparing two treatments. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Forest plot of network meta‐analysis of all trials for early postoperative vomiting. Single drugs and combinations were compared with placebo (reference compound). RR = risk ratio, 95% CI = 95% confidence interval. RR < 1 favours the intervention, RR > 1 favours placebo. The blue lines indicate the range of equivalence (RR = 0.8 to 1.25). Treatments are ranked according to efficacy based on P scores. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Network geometry of eligible comparisons for late postoperative vomiting. The thickness of the edges is proportionate to the number of included studies comparing two treatments. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Forest plot of network meta‐analysis of all trials for late postoperative vomiting. Single drugs and combinations were compared with placebo (reference compound). RR = risk ratio, 95% CI = 95% confidence interval. RR < 1 favours the intervention, RR > 1 favours placebo. The blue lines indicate the range of equivalence (RR = 0.8 to 1.25). Treatments are ranked according to efficacy based on P scores. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Network geometry of eligible comparisons for postoperative nausea within 24 hours postoperatively. The thickness of the edges is proportionate to the number of included studies comparing two treatments. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Forest plot of network meta‐analysis of all trials for postoperative nausea within 24 hours postoperatively. Single drugs and combinations were compared with placebo (reference compound). RR = risk ratio, 95% CI = 95% confidence interval. RR < 1 favours the intervention, RR > 1 favours placebo. The blue lines indicate the range of equivalence (RR = 0.8 to 1.25). Treatments are ranked according to efficacy based on P scores. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Network geometry of eligible comparisons for complete response within 24 hours postoperatively. The thickness of the edges is proportionate to the number of included studies comparing two treatments. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Forest plot of network meta‐analysis of all trials for complete response within 24 hours postoperatively. Single drugs and combinations were compared with placebo (reference compound). RR = risk ratio, 95% CI = 95% confidence interval. RR > 1 favours the intervention, RR < 1 favours placebo. The blue lines indicate the range of equivalence (RR = 0.8 to 1.25). Treatments are ranked according to efficacy based on P scores. Abbreviations for treatments correspond to the first four letters of the drug name and are listed in the Methods and in Appendix 6.
Comparison 1: Amisulpride versus placebo, Outcome 1: Vomiting within 0 to 24 hours
Comparison 1: Amisulpride versus placebo, Outcome 2: Serious adverse events
Comparison 1: Amisulpride versus placebo, Outcome 3: Any adverse event
Comparison 1: Amisulpride versus placebo, Outcome 4: Headache
Comparison 1: Amisulpride versus placebo, Outcome 5: Sedation/drowsiness
Comparison 1: Amisulpride versus placebo, Outcome 6: Extrapyramidal symptoms
Comparison 1: Amisulpride versus placebo, Outcome 7: Constipation
Comparison 2: Aprepitant versus placebo, Outcome 1: Vomiting within 0 to 24 hours
Comparison 2: Aprepitant versus placebo, Outcome 2: Headache
Comparison 3: Dexamethasone versus placebo, Outcome 1: Vomiting within 0 to 24 hours
Comparison 3: Dexamethasone versus placebo, Outcome 2: Serious adverse events
Comparison 3: Dexamethasone versus placebo, Outcome 3: Any adverse event
Comparison 3: Dexamethasone versus placebo, Outcome 4: Headache
Comparison 3: Dexamethasone versus placebo, Outcome 5: Sedation/drowsiness
Comparison 3: Dexamethasone versus placebo, Outcome 6: Extrapyramidal symptoms
Comparison 3: Dexamethasone versus placebo, Outcome 7: Constipation
Comparison 3: Dexamethasone versus placebo, Outcome 8: Postoperative wound infection
Comparison 3: Dexamethasone versus placebo, Outcome 9: Arrhythmia
Comparison 3: Dexamethasone versus placebo, Outcome 10: Visual disturbances
Comparison 3: Dexamethasone versus placebo, Outcome 11: QT prolongation
Comparison 4: Dimenhydrinate versus placebo, Outcome 1: Vomiting within 0 to 24 hours
Comparison 4: Dimenhydrinate versus placebo, Outcome 2: Headache
Comparison 4: Dimenhydrinate versus placebo, Outcome 3: Sedation/drowsiness
Comparison 5: Dolasetron versus placebo, Outcome 1: Vomiting within 0 to 24 hours
Comparison 5: Dolasetron versus placebo, Outcome 2: Serious adverse events
Comparison 5: Dolasetron versus placebo, Outcome 3: Any adverse event
Comparison 5: Dolasetron versus placebo, Outcome 4: Headache
Comparison 5: Dolasetron versus placebo, Outcome 5: Sedation/drowsiness
Comparison 5: Dolasetron versus placebo, Outcome 6: Extrapyramidal symptoms
Comparison 5: Dolasetron versus placebo, Outcome 7: Arrhythmia
Comparison 6: Droperidol versus placebo, Outcome 1: Vomiting within 0 to 24 hours
Comparison 6: Droperidol versus placebo, Outcome 2: Serious adverse events
Comparison 6: Droperidol versus placebo, Outcome 3: Any adverse event
Comparison 6: Droperidol versus placebo, Outcome 4: Headache
Comparison 6: Droperidol versus placebo, Outcome 5: Sedation/drowsiness
Comparison 6: Droperidol versus placebo, Outcome 6: Extrapyramidal symptoms
Comparison 6: Droperidol versus placebo, Outcome 7: Arrhythmia
Comparison 6: Droperidol versus placebo, Outcome 8: Visual disturbances
Comparison 6: Droperidol versus placebo, Outcome 9: QT prolongation
Comparison 7: Granisetron versus placebo, Outcome 1: Vomiting within 0 to 24 hours
Comparison 7: Granisetron versus placebo, Outcome 2: Serious adverse events
Comparison 7: Granisetron versus placebo, Outcome 3: Any adverse event
Comparison 7: Granisetron versus placebo, Outcome 4: Headache
Comparison 7: Granisetron versus placebo, Outcome 5: Sedation/drowsiness
Comparison 7: Granisetron versus placebo, Outcome 6: Extrapyramidal symptoms
Comparison 7: Granisetron versus placebo, Outcome 7: Constipation
Comparison 7: Granisetron versus placebo, Outcome 8: Arrhythmia
Comparison 8: Haloperidol versus placebo, Outcome 1: Vomiting within 0 to 24 hours
Comparison 8: Haloperidol versus placebo, Outcome 2: Headache
Comparison 8: Haloperidol versus placebo, Outcome 3: Extrapyramidal symptoms
Comparison 8: Haloperidol versus placebo, Outcome 4: Arrhythmia
Comparison 8: Haloperidol versus placebo, Outcome 5: QT prolongation
Comparison 9: Methylprednisolone versus placebo, Outcome 1: Sedation/drowsiness
Comparison 9: Methylprednisolone versus placebo, Outcome 2: Postoperative wound infection
Comparison 9: Methylprednisolone versus placebo, Outcome 3: Arrhythmia
Comparison 9: Methylprednisolone versus placebo, Outcome 4: Visual disturbances
Comparison 10: Metoclopramide versus placebo, Outcome 1: Vomiting within 0 to 24 hours
Comparison 10: Metoclopramide versus placebo, Outcome 2: Any adverse event
Comparison 10: Metoclopramide versus placebo, Outcome 3: Headache
Comparison 10: Metoclopramide versus placebo, Outcome 4: Sedation/drowsiness
Comparison 10: Metoclopramide versus placebo, Outcome 5: Extrapyramidal symptoms
Comparison 10: Metoclopramide versus placebo, Outcome 6: Constipation
Comparison 10: Metoclopramide versus placebo, Outcome 7: Postoperative wound infection
Comparison 10: Metoclopramide versus placebo, Outcome 8: Arrhythmia
Comparison 10: Metoclopramide versus placebo, Outcome 9: Visual disturbances
Comparison 11: Ondansetron versus placebo, Outcome 1: Vomiting within 0 to 24 hours
Comparison 11: Ondansetron versus placebo, Outcome 2: Serious adverse events
Comparison 11: Ondansetron versus placebo, Outcome 3: Any adverse event
Comparison 11: Ondansetron versus placebo, Outcome 4: Headache
Comparison 11: Ondansetron versus placebo, Outcome 5: Sedation/drowsiness
Comparison 11: Ondansetron versus placebo, Outcome 6: Extrapyramidal symptoms
Comparison 11: Ondansetron versus placebo, Outcome 7: Constipation
Comparison 11: Ondansetron versus placebo, Outcome 8: Arrhythmia
Comparison 11: Ondansetron versus placebo, Outcome 9: Visual disturbances
Comparison 11: Ondansetron versus placebo, Outcome 10: QT prolongation
Comparison 12: Palonosetron versus placebo, Outcome 1: Vomiting within 0 to 24 hours
Comparison 12: Palonosetron versus placebo, Outcome 2: Serious adverse events
Comparison 12: Palonosetron versus placebo, Outcome 3: Any adverse event
Comparison 12: Palonosetron versus placebo, Outcome 4: Headache
Comparison 12: Palonosetron versus placebo, Outcome 5: Sedation/drowsiness
Comparison 12: Palonosetron versus placebo, Outcome 6: Extrapyramidal symptoms
Comparison 12: Palonosetron versus placebo, Outcome 7: Constipation
Comparison 12: Palonosetron versus placebo, Outcome 8: QT prolongation
Comparison 13: Perphenazine versus placebo, Outcome 1: Sedation/drowsiness
Comparison 13: Perphenazine versus placebo, Outcome 2: Extrapyramidal symptoms
Comparison 14: Promethazine versus placebo, Outcome 1: Vomiting within 0 to 24 hours
Comparison 14: Promethazine versus placebo, Outcome 2: Headache
Comparison 14: Promethazine versus placebo, Outcome 3: Sedation/drowsiness
Comparison 15: Ramosetron versus placebo, Outcome 1: Vomiting within 0 to 24 hours
Comparison 15: Ramosetron versus placebo, Outcome 2: Serious adverse events
Comparison 15: Ramosetron versus placebo, Outcome 3: Any adverse event
Comparison 15: Ramosetron versus placebo, Outcome 4: Headache
Comparison 15: Ramosetron versus placebo, Outcome 5: Sedation/drowsiness
Comparison 15: Ramosetron versus placebo, Outcome 6: Constipation
Comparison 15: Ramosetron versus placebo, Outcome 7: Arrhythmia
Comparison 16: Rolapitant versus placebo, Outcome 1: Vomiting within 0 to 24 hours
Comparison 17: Scopalamine versus placebo, Outcome 1: Vomiting within 0 to 24 hours
Comparison 17: Scopalamine versus placebo, Outcome 2: Serious adverse events
Comparison 17: Scopalamine versus placebo, Outcome 3: Any adverse event
Comparison 17: Scopalamine versus placebo, Outcome 4: Headache
Comparison 17: Scopalamine versus placebo, Outcome 5: Sedation/drowsiness
Comparison 17: Scopalamine versus placebo, Outcome 6: Visual disturbances
Comparison 18: Tropisetron versus placebo, Outcome 1: Vomiting within 0 to 24 hours
Comparison 18: Tropisetron versus placebo, Outcome 2: Serious adverse events
Comparison 18: Tropisetron versus placebo, Outcome 3: Any adverse event
Comparison 18: Tropisetron versus placebo, Outcome 4: Headache
Comparison 18: Tropisetron versus placebo, Outcome 5: Sedation/drowsiness
Comparison 18: Tropisetron versus placebo, Outcome 6: Extrapyramidal symptoms
Comparison 18: Tropisetron versus placebo, Outcome 7: Constipation
Comparison 18: Tropisetron versus placebo, Outcome 8: Postoperative wound infection
Comparison 18: Tropisetron versus placebo, Outcome 9: Arrhythmia
Comparison 18: Tropisetron versus placebo, Outcome 10: Visual disturbances
Comparison 18: Tropisetron versus placebo, Outcome 11: QT prolongation
Update of
- doi: 10.1002/14651858.CD012859
References
References to studies included in this review
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Agarwal 2002 {published data only}
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Ahmed 2000 {published data only}
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Akin 2006 {published data only}
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Alexander 1997 {published data only}
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Alghanem 2010 {published data only}
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Alia 2015 {published data only}
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Ali Melkkila 1996 {published data only}
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Alkaissi 2004 {published data only}
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Alon 1996 {published data only}
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Alonso Damian 2012 {published data only}
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Altorjay 2011 {published data only}
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- NCT00326248. Casopitant (Oral) and ZOFRAN to Prevent Postoperative Nausea and Vomiting In Women [A Phase III, Multicenter, Randomized, Double-blind, Parallel Group Study to Evaluate the Safety and Efficacy of 50mg Oral Dosing With the Neurokinin-1 Receptor Antagonist GW679769 for the Prevention of Postoperative Nausea and Vomiting in Female Subjects at High Risk for Emesis]. clinicaltrials.gov/ct2/show/NCT00326248 (first received 16 May 2006).
Altunkaya 2003 {published data only}
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Amer 2012 {published data only}
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Ansari 2010 {published data only}
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Aouad 2007 {published data only}
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Apfel 2004‐1 {published data only}
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Apfel 2004‐2 {published data only}
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Areeruk 2016 {published data only}
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Argiriadou 2002 {published data only}
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- Argiriadou H, Papaziogas, B, Pavlidis T, Parlapani A, Georgiou M, Papagiannopoulou P, et al. Tropisetron vs ondansetron for prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy: a randomized double-blind, placebo-controlled study. Surgical Endoscopy 2002;16(7):1087-90. [PMID: 12165828 ] - PubMed
Arslan 2011 {published data only}
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Asadollah 2014 {published data only}
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Ascaso 1997 {published data only}
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Awad 2002 {published data only}
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Bacic 1998 {published data only}
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Backes 2013 {published data only}
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Badaoui 1998 {published data only}
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- Badaoui R, Yagoubi A, Pouilly A, Carpentier F, Riboulot M, Ossart M. Comparison between ondansetron and droperidol in preventing postoperative nausea and vomiting after laparoscopic cholecystectomy. Cahiers d'Anesthesiologie 1998;46(3):171-4.
Badaoui 1999 {published data only}
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- Badaoui R, Pouilly A, Yagoubi A, Carpentier F, Riboulot M, Ossart M. Comparative study between ondansetron and droperidol in preventing postoperative nausea and vomiting after general surgery. British Journal of Anaesthesia 1999;82 Suppl 1:121.
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- Badaoui R, Pouilly A, Yagoubi A, Carpentier F, Riboulot M, Ossart M. Comparison of ondansetron and droperidol in the prevention of postoperative nausea and vomiting. Cahiers d'Anesthesiologie 1999;47(5):297-301.
Bailey 1990 {published data only}
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- Bailey PL, Streisand JB, Pace NL, Bubbers SJ, East KA, Mulder S, et al. Transdermal scopolamine reduces nausea and vomiting after outpatient laparoscopy. Anesthesiology 1990;72(6):977-80. [PMID: ] - PubMed
Bajwa 2011 {published data only}
Bala 2014 {published data only}
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- Bala I, Bharti N, Murugesan S, Gupta R. Comparison of palonosetron with palonosetron-dexamethasone combination for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Minerva Anestesiologica 2014;80(7):779-84. [PMID: 24280811] - PubMed
Bang 2016 {published data only}
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- Bang YS, Kim YU, Oh D, Shin EY, Park SK. A randomized, double-blind trial evaluating the efficacy of palonosetron with total intravenous anesthesia using propofol and remifentanil for the prevention of postoperative nausea and vomiting after gynecologic surgery. Journal of Anesthesia 2016;30(6):935-40. [DOI: 10.1007/s00540-016-2249-3] [PMID: ] - DOI - PubMed
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- NCT01478165. Comparison of TIVA (Total Intravenous Anesthesia) and TIVA Plus Palonosetron in Preventing Postoperative Nausea and Vomiting. clinicaltrials.gov/ct2/show/NCT01478165 (first received 23 November 2011).
Bang 2017 {published data only}
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- Bang SR, Kim HJ, Ahn EJ, Choi HR, Kim KW, Ko MJ, et al. Effect of total intravenous anesthesia and prophylactic 5-HT3 receptor antagonist on postoperative nausea and vomiting after gynecologic laparoscopic surgery: a prospective, randomized controlled study. Rawal Medical Journal 2017;42(1):73-7.
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Bano 2008 {published data only}
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- Bano F, Zafar S, Aftab S, Haider S. Dexamethasone plus ondansetron for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a comparison with dexamethasone alone. Journal of the College of Physicians & Surgeons - Pakistan 2008;18(5):265-9. [PMID: ] - PubMed
Barbone 2004 {published data only}
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Barros 2013 {published data only}
Barrow 1994 {published data only}
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- Barrow PM, Hughes DG, Redfern N, Urie J. Influence of droperidol on nausea and vomiting during patient-controlled analgesia. British Journal of Anaesthesia 1994;72(4):460-1. [PMID: 8155452] - PubMed
Basu 2011 {published data only}
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- Basu A, Saha D, Hembrom BP, Roy A, Naaz A. Comparison of palanosetron, granisetron and ondansetron as anti-emetics for prevention of postoperative nausea and vomiting in patients undergoing middle ear surgery. Journal of the Indian Medical Association 2011;109(5):327-9. [PMID: ] - PubMed
Bataille 2016 {published data only}
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- Bataille A, Letourneulx JF, Charmeau A, Lemedioni P, Léger P, Chazot T, et al. Impact of a prophylactic combination of dexamethasone-ondansetron on postoperative nausea and vomiting in obese adult patients undergoing laparoscopic sleeve gastrectomy during closed-loop propofol-remifentanil anaesthesia: a randomised double-blind placebo-controlled study. European Journal of Anaesthesiology 2016;33(12):898-905. [PMID: 26866433 ] - PubMed
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- NCT01876290. Dexamethasone and Ondansetron Versus Placebo for Postoperative Nausea and Vomiting (Loop-NVPO) [Should We Associate Dexamethasone and Ondansetron to Closed-loop Anesthesia to Reduce the Incidence of Postoperative Nausea and Vomiting After Bariatric Surgery?]. clinicaltrials.gov/ct2/show/NCT01876290 (first received 12 June 2013).
Baxendale 1993 {published data only}
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Beattie 1993 {published data only}
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- Beattie WS, Lindblad T, Buckley DN, Forrest JB. Menstruation increases the risk of nausea and vomiting after laparoscopy. A prospective randomized study. Anesthesiology 1993;78(2):272-6. [PMID: 8439022] - PubMed
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- Lindblad T, Beattie WS, Forrest JB, Buckley DN. Loss of the antiemetic effect of droperidol in menstruating women. Canadian Journal of Anaesthesia 1990;37(4):S139. [PMID: ] - PubMed
Benevides 2013 {published data only}
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- Benevides Ml, Oliveira SS, Aguilar-Nascimento JE. Combination of haloperidol, dexamethasone, and ondansetron reduces nausea and pain intensity and morphine consumption after laparoscopic sleeve gastrectomy. Brazilian Journal of Anesthesiology 2013;63(5):404-9. [DOI: 10.1016/j.bjan.2012.07.011] [PMID: ] - DOI - PubMed
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- Benevides ML, Oliveira SS, Aguilar-Nascimento JE. The combination of haloperidol, dexamethasone, and ondansetron for prevention of postoperative nausea and vomiting in laparoscopic sleeve gastrectomy: a randomized double-blind trial. Obesity Surgery 2013;23(9):1389-96. [DOI: 10.1007/s11695-013-0923-1] [PMID: 23529851 ] - DOI - PubMed
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- RBR-4bxdhb. Prevention of Nausea and Vomiting After Surgery for Stomach Reduction in Obese Individuals. who.int/trialsearch/Trial2.aspx?TrialID=RBR-4bxdhb (first received 06 May 2012).
Bergese 2016 {published data only}
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- Bergese SD, Puente EG, Antor MA, Viloria AL, Yildiz V, Kumar NA, et al. A prospective, randomized, double-blinded, double-dummy pilot study to assess the preemptive effect of triple therapy with aprepitant, dexamethasone, and promethazine versus ondansetron, dexamethasone and promethazine on reducing the incidence of postoperative nausea and vomiting experienced by patients undergoing craniotomy under general anesthesia. Frontiers in Medicine 2016;3:29. [PMID: ] - PMC - PubMed
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- Dalal P, Portillo J, Tulman D, Thongrong C, Lopez E, Otey A, et al. A double-blind, double-arm prospective study on the efficacy of aprepitant versus ondansetron in the triple-therapy treatment of postoperative nausea and vomiting. Journal of Neurosurgical Anesthesiology 2012;24(4):470.
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- NCT01474915. Aprepitant Versus Ondansetron in Preoperative Triple-therapy Treatment of Nausea and Vomiting. clinicaltrials.gov/ct2/show/NCT01474915 (first received 18 November 2011).
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- Uribe AA, Puente EG, Viloria A, Schultz A, Zisman G, Bergese SD. Aprepitant vs ondansetron as triple-therapy for the prophylaxis of postoperative nausea and vomiting. Anesthesia and Analgesia 2011;112(5 Suppl 1):S-276. [DOI: 10.1213/01.ANE.0000403380.73932.6a] - DOI
Bestas 2007 {published data only}
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- Bestas A, Onal SA, Bayar MK, Yildirim A, Aygen E. Effects of ondansetron and granisetron on postoperative nausea and vomiting in adult patients undergoing laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled clinical trial. Current Therapeutic Research - Clinical and Experimental 2007;68(5):303-12. [DOI: 10.1016/j.curtheres.2007.10.003] [PMID: 24692762 ] - DOI - PMC - PubMed
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- Bhatia N, Katyal S, Grewal A, Kaul TK. Antiemetic prophylaxis with granisetron, ondansetron and metoclopramide in ambulatory gynaecological laparoscopic surgery: a comparison. Journal of Anaesthesiology, Clinical Pharmacology 2008;24(3):303-6.
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- Bhatnagar S, Gupta D, Mishra S, Srikanti M, Singh M, Arora R. Preemptive antiemesis in patients undergoing modified radical mastectomy: oral granisetron versus oral ondansetron in a double-blind, randomized, controlled study. Journal of Clinical Anesthesia 2007;19(7):512-6. [PMID: 18063205 ] - PubMed
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- Bhattacharya D, Banerjee A. Comparison of ondansetron and granisetron for prevention of nausea and vomiting following day care gynaecological laparoscopy. Indian Journal of Anaesthesia 2003;47(4):279-82.
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- Bhattarai B, Shrestha S, Singh J. Comparison of ondansetron and combination of ondansetron and dexamethasone as a prophylaxis for postoperative nausea and vomiting in adults undergoing elective laparoscopic surgery. Journal of Emergencies Trauma and Shock 2011;4(2):168-72. [PMID: 21769200 ] - PMC - PubMed
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- Bilgin TE, Birbicer H, Ozer Z, Doruk N, Tok E, Oral U. A comparative study of the antiemetic efficacy of dexamethasone, ondansetron, and metoclopramide in patients undergoing gynecological surgery. Medical Science Monitor 2010;16(7):336-41. [PMID: ] - PubMed
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- Bisgaard T, Schulze S, Christian Hjortsø N, Rosenberg J, Bjerregaard Kristiansen V. Randomized clinical trial comparing oral prednisone (50 mg) with placebo before laparoscopic cholecystectomy. Surgical Endoscopy 2008;22(2):566-72. [PMID: 18095022 ] - PubMed
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- Blitz JD, Haile M, Kline R, Franco L, Didehvar S, Pachter HL, et al. A randomized double blind study to evaluate efficacy of palonosetron with dexamethasone versus palonosetron alone for prevention of postoperative and postdischarge nausea and vomiting in subjects undergoing laparoscopic surgeries with high emetogenic risk. American Journal of Therapeutics 2012;19(5):324-9. [DOI: 10.1097/MJT.0b013e318209dff1] [PMID: 21519222 ] - DOI - PubMed
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- Candiotti KA, Kovac AL, Melson TI, Clerici G, Joo Gan T. A randomized, double-blind study to evaluate the efficacy and safety of three different doses of palonosetron versus placebo for preventing postoperative nausea and vomiting. Anesthesia and Analgesia 2008;107(2):445-51. [DOI: 10.1213/ane.0b013e31817b5ebb] [PMID: ] - DOI - PubMed
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- Chaparro LE, Gallo T, Gonzalez NJ, Rivera MF, Peng PW. Effectiveness of combined haloperidol and dexamethasone versus dexamethasone only for postoperative nausea and vomiting in high-risk day surgery patients: a randomized blinded trial. European Journal of Anaesthesiology 2010;27(2):192-5. [DOI: 10.1097/EJA.0b013e32832fce15] [PMID: 19915480 ] - DOI - PubMed
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- Chen PP, Chui PT, Gin T. Comparison of ondansetron and metoclopramide for the prevention of post-operative nausea and vomiting after major gynaecological surgery. European Journal of Anaesthesiology 1996;13(5):485-91. [PMID: ] - PubMed
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Chia 2004 {published data only}
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- Chia YY, Lo Y, Liu K, Tan PH, Chung NC, Ko NH. The effect of promethazine on postoperative pain: a comparison of preoperative, postoperative, and placebo administration in patients following total abdominal hysterectomy. Acta Anaesthesiologica Scandinavica 2004;48(5):625-30. [DOI: 10.1111/j.1399-6576.2004.00369.x] [PMID: 15101860 ] - DOI - PubMed
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- Choi IH, Oh JI, Do SH. A comparison of the effects of ondansetron and granisetron on the prevention of postoperative nausea and vomiting after gynecologic surgery. Korean Journal of Anesthesiology 1999;37(3):431-5. [PMID: 18158814 ] - PubMed
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- Choi YK, Kim HJ, Park SW, Kim KS. The optimal anti-emetic dose of ramosetron for prevention of postoperative nausea and vomiting following gynecologic surgery. Korean Journal of Anesthesiology 2008;54(5):538-43. [DOI: 10.4097/kjae.2008.54.5.538] - DOI
Choi 2010 {published data only}
Choi 2016 {published data only}
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- Choi EK, Kim DG, Jeon Y. Comparison of the prophylactic antiemetic efficacy of aprepitant plus palonosetron versus aprepitant plus ramosetron in patients at high risk for postoperative nausea and vomiting after laparoscopic cholecystectomy: a prospective randomized-controlled trial. Surgical Laparoscopy, Endoscopy and Percutaneous Techniques 2016;26(5):354-7. [DOI: 10.1097/SLE.0000000000000316] [PMID: 27636144 ] - DOI - PubMed
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Cholwill 1999 {published data only}
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- Cholwill JM, Wright W, Hobbs GJ, Curran J. Comparison of ondansetron and cyclizine for prevention of nausea and vomiting after day-case gynaecological laparoscopy. British Journal of Anaesthesia 1999;83(4):611-4. [PMID: ] - PubMed
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- Chu CC, Shieh JP, Tzeng JI, Chen JY, Lee Y, Ho ST, et al. The prophylactic effect of haloperidol plus dexamethasone on postoperative nausea and vomiting in patients undergoing laparoscopically assisted vaginal hysterectomy. Anesthesia and Analgesia 2008;106(5):1402-6. [DOI: 10.1213/ane.0b013e3181609424] [PMID: ] - DOI - PubMed
Chun 2014 {published data only}
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- KCT0000537. Palonosetron for the Prevention of PONV [The efficacy of palonosetron for the prevention of postoperative nausea and vomiting: a randomized double-blinded, placebo-controlled trial]. who.int/trialsearch/Trial2.aspx?TrialID=KCT0000537 (first received 14 September 2012).
Contreras Dominguez 2008 {published data only}
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- Contreras-Dominguez V, Carbonell-Bellolio P. Prophylactic antiemetic therapy for acute abdominal surgery. A comparative study of droperidol, metoclopramide, tropisetron, granisetron and dexamethasone. Revista Brasileira de Anestesiologia 2008;58(1):35-44. [PMID: ] - PubMed
Corcoran 2017 {published data only}
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- ACTRN12608000340336. Steroids Prevent Nausea and Vomiting After Day-case Surgery, But Do They Harm the Immune System? [The influence of antiemetic doses of dexamethasone on postoperative lymphocyte sub-populations after laparoscopic day-case gynaecological surgery]. who.int/trialsearch/Trial2.aspx?TrialID=ACTRN12608000340336 (first received 18 July 2008).
Cortes Flores 2018 {published data only}
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- Cortes-Flores AO, Jimenez-Tornero J, Morgan-Villela G, Delgado-Gomez M, Zuloaga-Fernandez Del Valle CJ, Garcia-Renteria J, et al. Effects of preoperative dexamethasone on postoperative pain, nausea, vomiting and respiratory function in women undergoing conservative breast surgery for cancer: results of a controlled clinical trial. European Journal of Cancer Care 2018;27(1):e12686. [PMID: ] - PubMed
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- Dabbous AS, Jabbour-Khoury SI, Nasr VG, Moussa AA, Zbeidy RA, Khouzam NE, et al. Dexamethasone with either granisetron or ondansetron for postoperative nausea and vomiting in laparoscopic surgery. Middle East Journal of Anaesthesiology 2010;20(4):565-70. [PMID: ] - PubMed
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- Delas Ramirez FJ, Ros Mora J, Ledesma Vazquez M, Lopez Rodriguez M, Fernandez Martinez MA, Villalonga Morales A. Three fixed doses of metoclopramide, droperidol or placebo to prevent postoperative nausea and vomiting in gynecological surgery. Revista Espanola de Anestesiologia y Reanimacion 2001;48(2):65-8. [PMID: ] - PubMed
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- Demirhan A, Tekelioglu UY, Akkaya A, Bilgi M, Apuhan T, Karabekmez FE, et al. Effect of pregabalin and dexamethasone addition to multimodal analgesia on postoperative analgesia following rhinoplasty surgery. Aesthetic Plastic Surgery 2013;37(6):1100-6. [DOI: 10.1007/s00266-013-0207-0] [PMID: ] - DOI - PubMed
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- de Oliveira GS Jr, Ahmad S, Fitzgerald PC, Marcus RJ, Altman CS, Panjwani AS, et al. Dose ranging study on the effect of preoperative dexamethasone on postoperative quality of recovery and opioid consumption after ambulatory gynaecological surgery. British Journal of Anaesthesia 2011;107(3):362-71. [PMID: 21669954 ] - PubMed
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DeOliveira 2016 {published data only}
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- de Oliveira GS Jr, Bialek J, Marcus RJ, McCarthy R. Dose-ranging effect of systemic diphenhydramine on postoperative quality of recovery after ambulatory laparoscopic surgery: a randomized, placebo-controlled, double-blinded, clinical trial. Journal of Clinical Anesthesia 2016;34:46-52. [PMID: ] - PubMed
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Derbent 2005 {published data only}
Desai 2013 {published data only}
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- Desai S, Santosh MC, Annigeri R, Santoshi VB, Rao R. Comparison of the antiemetic effect of ramosetron with the combination of dexamethasone and ondansetron in middle ear surgery: a double-blind, randomized clinical study. Saudi Journal of Anaesthesia 2013;7(3):254-8. [DOI: 10.4103/1658-354X.115328] [PMID: 24015126 ] - DOI - PMC - PubMed
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- Desilva PH, Darvish AH, McDonald SM, Cronin MK, Clark K. The efficacy of prophylactic ondansetron, droperidol, perphenazine, and metoclopramide in the prevention of nausea and vomiting after major gynecologic surgery. Anesthesia and Analgesia 1995;81(1):139-43. [PMID: ] - PubMed
Dewinter 2016 {published data only}
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- Dewinter G, Teunkens A, Vermeulen K, Devroe S, Van Hemelrijck J, Meuleman C, et al. Alizapride and ondansetron for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic gynaecological surgery: a double-blind, randomised, placebo-controlled noninferiority study. European Journal of Anaesthesiology 2016;33(2):96-103. [DOI: 10.1097/EJA.0000000000000288] [PMID: 26086285 ] - DOI - PubMed
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- Dewinter G, Velde M. A double-blind placebo controlled trial comparing alizapride and ondansetron in the prevention of postoperative nausea and vomiting (PONV) in patients undergoing gynaecological laparoscopy. Regional Anesthesia and Pain Medicine 2012;37(5 Suppl 1):e266-7. [DOI: 10.1097/AAP.0b013e31826a8366] - DOI
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- Goossens T, Teunkens A, Devroe S, Van De Velde M, Vanacker B, Dewinter G. A double-blind comparison between alizapride and ondansetron in the prevention of postoperative nausea and vomiting. Acta Anaesthesiologica Belgica 2010;61(2):97.
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- Witte JL, Schoenmaekers B, Sessler DI, Deloof T. The analgesic efficacy of tramadol is impaired by concurrent administration of ondansetron. Anesthesia and Analgesia 2001;92(5):1319-21. [PMID: ] - PubMed
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- Diamond MJ, Keeri-Szanto M. Reduction of postoperative vomiting by preoperative administration of oral metoclopramide. Canadian Anaesthetists' Society Journal 1980;27(1):36-9. [PMID: ] - PubMed
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- Didehvar S, Viola-Blitz JD, Haile M, Franco L, Kline R, Kurian M, et al. A randomized, double blind study to evaluate the efficacy of palono-setron with dexamethasone versus palonosetron alone for prevention of post-operative nausea and vomiting in subjects undergoing bariatric surgeries with high emetogenic risk. Open Anesthesiology Journal 2013;7(1):30-6. [DOI: 10.2174/1874321801307010030] - DOI
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- Diemunsch P, D'Hollander A, Paxton L, Schoeffler P, Wessel P, Navé S, et al. Intravenous dolasetron mesilate in the prevention of postoperative nausea and vomiting in females undergoing gynecological surgery. Journal of Clinical Anesthesia 1997;9(5):365-73. [PMID: ] - PubMed
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Diemunsch 1998 {published data only}
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- Diemunsch P, Korttila K, Leeser J, Helmers JH, Wilkey B, Navé S, et al. Oral dolasetron mesylate for prevention of postoperative nausea and vomiting: a multicenter, double-blind, placebo-controlled study. The Oral Dolasetron PONV Prevention Study Group. Journal of Clinical Anesthesia 1998;10(2):145-52. [9524901] - PubMed
Diemunsch 2007 {published data only}
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- Diemunsch P, Apfel C, Gan TJ, Candiotti K, Philip BK, Chelly J, et al. Preventing postoperative nausea and vomiting: post hoc analysis of pooled data from two randomized active-controlled trials of aprepitant. Current Medical Research and Opinion 2007;23(10):2559-65. [DOI: 10.1185/030079907X233115] - DOI - PubMed
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Dimov 2004 {published data only}
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- Dimov E, Uchikova E, Kamenov T, Milchev N, Terzhumanov R, Stefanov CH. Postoperative nausea and vomiting—possibility to prevent after long-lasting gynecological operations. Akusherstvo i Ginekologiia 2004;43(4):32-5. [PMID: ] - PubMed
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- Dobkin AB, Evers W, Israel JS. Double-blind evaluation of metoclopramide (MK 745, Sinemet), trimethobenzamide (Tigan), and a placebo as postanaesthetic anti-emetics following methoxyflurane anaesthesia. Canadian Anaesthetists' Society Journal 1968;15(1):80-91. [PMID: ] - PubMed
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- Doo AR, Oh SM, Kim BG, Ko S. Comparison of prophylactic anti-emetic effects of ramosetron between single bolus administration and continuous infusion following bolus administration. Anesthesia and Pain Medicine 2016;11(2):166-71. [DOI: 10.17085/apm.2016.11.2.166] - DOI
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- Eberhart LH, Seeling W, Hartschuh T, Morin AM, Georgieff M. Droperidol and dimenhydrinate alone or in combination for the prevention of post-operative nausea and vomiting after nasal surgery in male patients. European Journal of Anaesthesiology 1999;16(11):790-5. [PMID: ] - PubMed
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- Eberhart LH, Lindenthal M, Seeling W, Gäckle H, Georgieff M. Dolasetron, droperidol, and a combination of both drugs in the prevention of postoperative nausea and vomiting after extracapsular cataract extraction under general anaesthesia. Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie 1999;34(6):345-9. [PMID: ] - PubMed
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- Eberhart LH, Lindenthal M, Seeling W, Gackle H, Georgieff M. Dolasetron, droperidol, and dolasetron-droperidol combination in the prevention of PONV after extracapsular cataract extraction. British Journal of Anaesthesia 1999;82 Suppl 1:10-1. [PMID: ] - PubMed
Eberhart 2004 {published data only}
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- Eberhart LHJ, Morin AM, Hoerle S, Wulf H, Geldner G, Brown GC. Droperidol and dolasetron alone or in combination for prevention of postoperative nausea and vomiting after vitrectomy. Evidence-Based Ophthalmology 2005;6(1):22-3. - PubMed
Eberhart 2006 {published data only}
Eberhart 2011 {published data only}
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- Eberhart LH, Graf J, Morin AM, Stief T, Kalder M, Lattermann R, et al. Randomised controlled trial of the effect of oral premedication with dexamethasone on hyperglycaemic response to abdominal hysterectomy. European Journal of Anaesthesiology 2011;28(3):195-201. [DOI: 10.1097/EJA.0b013e32834296b9] [PMID: ] - DOI - PubMed
Ebneshahidi 2013 {published data only}
Eidi 2012 {published data only}
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- IRCT201106154005N4. Comparison of Ondansetron and Dexamethasone in Prevention of Nausea and Vomiting [Comparison of preoperative Ondansetron and Dexamethasone in prevention of postoperative nausea and vomiting after middle ear surgeries]. who.int/trialsearch/Trial2.aspx?TrialID=IRCT201106154005N4 (first received 4 July 2011).
Ekinci 2011 {published data only}
El Deeb 2011 {published data only}
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- El-Deeb A, Ali Y, Rashdy H. Evaluation of combination antiemetic prophylaxis in high risk emetogenic patients undergoing thyroid surgery: a randomized double-blind study. Egyptian Journal of Anaesthesia 2011;27(4):203-6. [DOI: 10.1016/j.egja.2011.08.002] - DOI
Elhakim 1995 {published data only}
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- Elhakim M, Ghalaab M, Soliman M. Effects of odansetron and balanced analgesia on postoperative nausea and vomiting in laparoscopic surgery. Acta Anaesthesiologica Italica 1995;46(Suppl 1):23-8.
Elhakim 2002 {published data only}
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- Elhakim M, Nafie M, Mahmoud K, Atef A. Dexamethasone 8 mg in combination with ondansetron 4 mg appears to be the optimal dose for the prevention of nausea and vomiting after laparoscopic cholecystectomy. Canadian Journal of Anesthesia 2002;49(9):922-6. [PMID: 12419717 ] - PubMed
Entezariasl 2010 {published data only}
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- Entezariasl M, Khoshbaten M, Isazadehfar K, Akhavanakbari G. Efficacy of metoclopramide and dexamethasone for postoperative nausea and vomiting: a double-blind clinical trial. Eastern Mediterranean Health Journal 2010;16(3):300-3. [PMID: ] - PubMed
Erhan 2008 {published data only}
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- Erhan Y, Erhan E, Aydede H, Yumus O, Yentur A. Ondansetron, granisetron, and dexamethasone compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a randomized placebo-controlled study. Surgical Endoscopy 2008;22(6):1487-92. [PMID: 18027038] - PubMed
Eriksson 1996 {published data only}
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- Eriksson H, Korttila K. Recovery profile after desflurane with or without ondansetron compared with propofol in patients undergoing outpatient gynecological laparoscopy. Anesthesia and Analgesia 1996;82(3):533-8. [PMID: 8623957] - PubMed
Ersayli 2006 {published data only}
Esmaili 2004 {published data only}
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- Esmaili MH, Kardan K. The effects of betamethasone on reducing the postoperative pain, nausea, and vomiting. Archives of Iranian Medicine 2004;7(2):145-8.
Fabling 2000 {published data only}
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- Fabling JM, Gan TJ, El-Moalem HE, Warner DS, Borel CO. A randomized, double-blinded comparison of ondansetron, droperidol, and placebo for prevention of postoperative nausea and vomiting after supratentorial craniotomy. Anesthesia and Analgesia 2000;91(2):358-61. [PMID: ] - PubMed
Fabling 2002 {published data only}
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- Fabling JM, Gan TJ, El-Moalem HE, Warner DS, Borel CO. A randomized, double-blind comparison of ondansetron versus placebo for prevention of nausea and vomiting after infratentorial craniotomy. Journal of Neurosurgical Anesthesiology 2002;14(2):102-7. [PMID: ] - PubMed
Fahlenkamp 2016 {published data only}
-
- EUCTR2008-004132-20-DE. This protocol describes a total of three studies that are intrinsically linked. It does therefore have three titles. 1. The Effect of Xenon and Sevoflurane on Depth of Hypnosis Monitors When Titrated to Standard Anaesthesia Parameter. 2. The Efficacy of Dexamethasone for Prevention of PONV After Xenon or Sevoflurane. 3. Ondansetron as Rescue for the Treatment of Established PONV After Xenon or Sevoflurane. who.int/trialsearch/Trial2.aspx?TrialID=EUCTR2008-004132-20-DE (first received 10 September 2008).
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- NCT00793663. Depth of Hypnosis and Postoperative Nausea and Vomiting During Xenon Anaesthesia (XABP). clinicaltrials.gov/ct2/show/NCT00793663 (first received 19 November 2008).
Feng 2009 {published data only}
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- Feng PH, Chu KS, Lu IC, Shieh JP, Tzeng JI, Ho ST, et al. Haloperidol plus ondansetron prevents postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Acta Anaesthesiologica Taiwanica 2009;47(1):3-9. [DOI: 10.1016/S1875-4597(09)60013-8] [PMID: 19318293 ] - DOI - PubMed
Feo 2006 {published data only}
Feroci 2011 {published data only}
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- Feroci F, Rettori M, Borrelli A, Lenzi E, Ottaviano A, Scatizzi M. Dexamethasone prophylaxis before thyroidectomy to reduce postoperative nausea, pain, and vocal dysfunction: a randomized clinical controlled trial. Head and Neck 2011;33(6):840-6. [PMID: ] - PubMed
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- Feroci F, Rettori M, Borrelli A, Lenzi E, Scatizzi M. Use of dexamethasone in the prevention of PONV after thyroid surgery. European Surgical Research 2010;45(3-4):182.
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- NCT00888303. Single Dose Steroid Before Thyroidectomy for Benign Disease to Improve Postoperative Nausea, Pain, and Vocal Function [Randomized Controlled Trial on Efficacy of Preemptive 8 mg of Dexamethasone for Reducing Pain and Postoperative Nausea and Vomit After Thyroidectomy for Benign Disease]. clinicaltrials.gov/ct2/show/NCT00888303 (first received 27 April 2009).
Forrester 2007 {published data only}
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- Forrester CM, Benfield DA Jr, Matern CE, Kelly JA, Pellegrini JE. Meclizine in combination with ondansetron for prevention of postoperative nausea and vomiting in a high-risk population. AANA Journal 2007;75(1):27-33. [PMID: ] - PubMed
Fortney 1998 {published data only}
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- Fortney JT, Gan TJ, Graczyk S, Wetchler B, Melson T, Khalil S, et al. A comparison of the efficacy, safety, and patient satisfaction of ondansetron versus droperidol as antiemetics for outpatient surgical procedures. Anesthesia and Analgesia 1998;86(4):731-8. [PMID: ] - PubMed
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- Habib As, Gan TJ. The effectiveness of rescue antiemetics after failure of prophylaxis with ondansetron or droperidol: a preliminary report. Journal of Clinical Anesthesia 2005;17(1):62-5. [PMID: ] - PubMed
Foster 1996 {published data only}
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- Foster PN, Stickle BR, Laurence AS. Akathisia following low-dose droperidol for antiemesis in day-case patients. Anaesthesia 1996;51(5):491-4. [PMID: 8694168] - PubMed
Fukami 2009 {published data only}
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- Fukami Y, Terasaki M, Okamoto Y, Sakaguchi K, Murata T, Ohkubo M, et al. Efficacy of preoperative dexamethasone in patients with laparoscopic cholecystectomy: a prospective randomized double-blind study. Journal of Hepato-Biliary-Pancreatic Surgery 2009;16(3):367-71. [PMID: 19333536 ] - PubMed
Gallinger 2007 {published data only}
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- Gallinger EIu, Likhvantsev VV, Basov VE. Prevention regimens for postoperative nausea and vomiting during emergency gynecological laparoscopic operations (clinical and economic analysis). Anesteziologiia i Reanimatologiia 2007;4:56-7. [PMID: ] - PubMed
Gan 1994 {published data only}
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- Gan TJ, Collis R, Hetreed M. Double-blind comparison of ondansetron, droperidol and saline in the prevention of postoperative nausea and vomiting. British Journal of Anaesthesia 1994;72(5):544-7. [PMID: ] - PubMed
Gan 2004 {published data only}
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- Gan TJ, Jiao KR, Zenn M, Georgiade G. A randomized controlled comparison of electro-acupoint stimulation or ondansetron versus placebo for the prevention of postoperative nausea and vomiting. Anesthesia and Analgesia 2004;99(4):1070-5. [DOI: 10.1213/01.ANE.0000130355.91214.9E] [PMID: ] - DOI - PubMed
Gan 2005 {published data only}
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- Gan TJ, Coop A, Philip BK. A randomized, double-blind study of granisetron plus dexamethasone versus ondansetron plus dexamethasone to prevent postoperative nausea and vomiting in patients undergoing abdominal hysterectomy. Anesthesia and Analgesia 2005;101(5):1323-9. [DOI: 10.1213/01.ANE.0000180366.65267.F6] [PMID: 16243988 ] - DOI - PubMed
Gan 2007 {published data only}
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- Gan TJ, Apfel CC, Kovac A, Philip BK, Singla N, Minkowitz H, et al, Aprepitant-PONV Study Group. A randomized, double-blind comparison of the NK1 antagonist, aprepitant, versus ondansetron for the prevention of postoperative nausea and vomiting. Anesthesia and Analgesia 2007;104(5):1082-9. [DOI: 10.1213/01.ane.0000263277.35140.a3] [PMID: ] - DOI - PubMed
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- NCT00090155. 2 Doses of an Approved Drug Being Studied for a New Indication for the Prevention of Postoperative Nausea and Vomiting (0869-090) [A Randomized, Double-Blind, Active Comparator-Controlled, Parallel-Group Study, Conducted Under In-House Blinding Conditions, to Examine the Safety, Tolerability, and Efficacy of 2 Doses of Aprepitant for the Prevention of Postoperative Nausea and Vomiting]. clinicaltrials.gov/ct2/show/NCT00090155 (first received 27 August 2004).
Gan 2009 {published data only}
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- Gan TJ, Sinha AC, Kovac AL, Jones RK, Cohen SA, Battikha JP, et al. A randomized, double-blind, multicenter trial comparing transdermal scopolamine plus ondansetron to ondansetron alone for the prevention of postoperative nausea and vomiting in the outpatient setting. Anesthesia and Analgesia 2009;108(5):1498-504. [DOI: 10.1213/ane.0b013e31819e431f] [PMID: 19372328 ] - DOI - PubMed
Gan 2011 {published data only}
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- Gan TJ, Gu J, Singla N, Chung F, Pearman MH, Bergese SD, et al, Rolapitant Investigation Group. Rolapitant for the prevention of postoperative nausea and vomiting: a prospective, double-blinded, placebo-controlled randomized trial. Anesthesia and Analgesia 2011;112(4):804-12. [DOI: 10.1213/ANE.0b013e31820886c3] [PMID: 21385988 ] - DOI - PubMed
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- Habib AS, Bergese SD, Gu J, Apfel CC, Cantillion M, Gan TJ. The impact of postoperative nausea and vomiting on the quality of recovery following anesthesia. Anesthesia and Analgesia 2010;110(3 Suppl 1):5. [DOI: 10.1213/01.ANE.0000398215.59935.49] - DOI
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- NCT00539721. A Randomized Controlled Study of Rolapitant for the Prevention of Nausea and Vomiting Following Surgery (Study P04937AM1) [A Randomized, Double-Blind, Double-Dummy, Dose-Ranging, Active- and Placebo-Controlled Study of Single-Dose Oral Rolapitant Monotherapy for the Prevention of Postoperative Nausea and Vomiting (PONV)]. clinicaltrials.gov/ct2/show/NCT00539721 (first received 4 October 2007).
Gan 2017 {published data only}
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- Gan TJ, Kranke P, Minkowitz HS, Bergese SD, Motsch J, Eberhart L, et al. Intravenous amisulpride for the prevention of postoperative nausea and vomiting: two concurrent, randomized, double-blind, placebo-controlled trials. Anesthesiology 2017;126(2):268-75. [DOI: 10.1097/ALN.0000000000001458] [PMID: ] - DOI - PubMed
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- NCT01991821. European Phase III Study of APD421 in PONV [Randomised, Double-blind, Placebo-controlled Phase III Study of APD421 (Amisulpride for IV Injection) as Prophylaxis Against Post-operative Nausea and Vomiting]. clinicaltrials.gov/ct2/show/NCT01991821 (first received 25 November 2013).
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- NCT01991860. US Phase III Study of APD421 in PONV [Randomized, Double-blind, Placebo-controlled Phase III Study of APD421 (Amisulpride for IV Injection) as Prophylaxis Against Post-operative Nausea and Vomiting]. clinicaltrials.gov/ct2/show/NCT01991860 (first received 25 November 2013).
Gandhi 2009 {published data only}
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- Gandhi R, Jain A, Kumar A. Ondansetron/dexamethasone for prophylaxis against postoperative nausea and vomiting. Journal of Anaesthesiology, Clinical Pharmacology 2009;25(3):305-10.
Ganem 2001 {published data only}
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- Ganem EM, Fabris P, Moro MZ, Castiglia YM. Efficacy of ondansetron and alizapride in preventing gynecological laparoscopy nausea and vomiting. Revista Brasileira de Anestesiologia 2001;51(5):401-6.
Ganem 2002 {published data only}
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- Ganem EM, Fukushima FB, Silva DS, Nakamura G, Castiglia YM, Vianna PT. Efficacy of propofol and propofol plus dexamethasone in controlling postoperative nausea and vomiting of gynecologic laparoscopy. Revista Brasileira de Anestesiologia 2002;52(4):394-401. [PMID: ] - PubMed
Gauchan 2014 {published data only}
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- Gauchan S, Thapa C, Shakya P, Bhattarai R, Shakya S. Ondansetron and granisetron for prevention of postoperative nausea and vomiting following laparoscopic cholecystectomy. Journal of the Nepal Medical Association 2014;52(193):682-6. [PMID: ] - PubMed
Gautam 2008 {published data only}
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- Gautam B, Shrestha BR, Lama P, Rai S. Antiemetic prophylaxis against postoperative nausea and vomiting with ondansetron-dexamethasone combination compared to ondansetron or dexamethasone alone for patients undergoing laparoscopic cholecystectomy. Kathmandu University Medical Journal 2008;6(23):319-28. [PMID: 20071813] - PubMed
Gautam 2014 {published data only}
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- Gautam S, Agarwal A, Das PK, Agarwal A, Kumar S, Khuba S. Evaluation of the efficacy of methylprednisolone, etoricoxib and a combination of the two substances to attenuate postoperative pain and PONV in patients undergoing laparoscopic cholecystectomy: a prospective, randomized, placebo-controlled trial. Korean Journal of Pain 2014;27(3):278-84. [DOI: 10.3344/kjp.2014.27.3.278] [PMID: 25031815 ] - DOI - PMC - PubMed
Gesztesi 2000‐1 {published data only}
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- Gesztesi Z, Scuderi PE, White PF, Wright W, Wender RH, D'Angelo R, et al. Substance P (neurokinin-1) antagonist prevents postoperative vomiting after abdominal hysterectomy procedure. Anesthesiology 2000;93(4):931-7. [PMID: ] - PubMed
Gesztesi 2000‐2 {published data only}
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- Gesztesi Z, Scuderi PE, White PF, Wright W, Wender RH, D'Angelo R, et al. Substance P (neurokinin-1) antagonist prevents postoperative vomiting after abdominal hysterectomy procedure. Anesthesiology 2000;93(4):931-7. [PMID: ] - PubMed
Ghosh 2011 {published data only}
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- Ghosh S, Pal A, Acharya A, Biswas C, Ghosh TR, Ghosh S. Palonosetron and palonosetron plus dexamethasone to prevent postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a prospective, randomized, double-blind comparative study. Albang Maqalat Wa Abhat Fi Altahdir Waalinas 2011;5(2):134-7. [PMID: ] - PMC - PubMed
Gijzels 2006 {published data only}
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- Gijzels MJ, Cobben JMG, Ploeger B. Haloperidol in the prevention of postoperative nausea and vomiting: an interim analysis. Pharmaceutisch Weekblad 2006;141(37):1163-6.
Glaser 2004 {published data only}
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- Glaser C, Sitzwohl C, Wallner T, Lerche A, Marhofer P, Schindler I. Dixyrazine for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy. Acta Anaesthesiologica Scandinavica 2004;48(10):1287-91. [PMID: 15504190] - PubMed
Goksu 2002 {published data only}
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- Goksu S, Kocoglu H, Bayazit YA, Yüksek S, Karci Y, Kanlikama M, et al. Antiemetic effects of granisetron, droperidol and dexamethasone in otologic surgery. Auris, Nasus, Larynx 2002;29(3):253-6. [PMID: 12167446] - PubMed
Goll 2001 {published data only}
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- Goll V, Akça O, Greif R, Freitag H, Arkiliç CF, Scheck T, et al. Ondansetron is no more effective than supplemental intraoperative oxygen for prevention of postoperative nausea and vomiting. Anesthesia and Analgesia 2001;92(1):112-7. [PMID: ] - PubMed
Gomez Hernandez 2010 {published data only}
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- Gómez-Hernández J, Orozco-Alatorre AL, Domínguez-Contreras M, Oceguera-Villanueva A, Gómez-Romo S, Alvarez Villaseñor AS, et al. Preoperative dexamethasone reduces postoperative pain, nausea and vomiting following mastectomy for breast cancer. BMC Cancer 2010;10:692. [DOI: 10.1186/1471-2407-10-692] [PMID: 21182781] - DOI - PMC - PubMed
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- NCT01116713. Effect of Dexamethasone in Postoperative Symptoms After Mastectomy for Breast Cancer (dxt2010brca) [Preoperative Dexamethasone Reduces Postoperative Pain, Nausea and Vomiting Following Mastectomy for Breast Cancer]. clinicaltrials.gov/ct2/show/NCT01116713 (first received 5 May 2010).
Graczyk 1997 {published data only}
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- Graczyk SG, McKenzie R, Kallar S, Hickok CB, Melson T, Morrill B, et al. Intravenous dolasetron for the prevention of postoperative nausea and vomiting after outpatient laparoscopic gynecologic surgery. Anesthesia and Analgesia 1997;84(2):325-30. [PMID: 9024022] - PubMed
Grecu 2008 {published data only}
Green 2012 {published data only}
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- Green MS, Green P, Malayaman SN, Hepler M, Neubert LJ, Horrow JC. Randomized, double-blind comparison of oral aprepitant alone compared with aprepitant and transdermal scopolamine for prevention of postoperative nausea and vomiting. British Journal of Anaesthesia 2012;109(5):716-22. [DOI: 10.1093/bja/aes233] [PMID: 22831888 ] - DOI - PubMed
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- NCT00659737. Comparison of Oral Aprepitant and Transdermal Scopolamine for Preventing Postoperative Nausea and Vomiting [A Randomized, Double-blind Comparison of Oral Aprepitant Alone Versus Oral Aprepitant and Transdermal Scopolamine for Preventing Postoperative Nausea and Vomiting]. clinicaltrials.gov/ct2/show/NCT00659737 (first received 16 April 2008).
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- NCT00717054. Comparison of Aprepitant Versus Aprepitant and Transdermal Scopolamine for Preventing Postoperative Nausea and Vomiting [A Randomized, Double-blind Comparison of Oral Aprepitant Alone vs Oral Aprepitant and Transdermal Scopolamine for Preventing Postoperative Nausea and Vomiting]. clinicaltrials.gov/ct2/show/NCT00717054 (first received 16 July 2008).
Grimsehl 2002 {published data only}
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- Grimsehl K, Whiteside JB, Mackenzie N. Comparison of cyclizine and ondansetron for the prevention of postoperative nausea and vomiting in laparoscopic day-case gynaecological surgery. Anaesthesia 2002;57(1):61-5. [PMID: ] - PubMed
Grond 1995 {published data only}
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- Grond S, Lynch J, Diefenbach C, Altrock K, Lehmann KA. Comparison of ondansetron and droperidol in the prevention of nausea and vomiting after inpatient minor gynecologic surgery. Anesthesia and Analgesia 1995;81(3):603-7. [PMID: ] - PubMed
Grover 2009 {published data only}
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- Grover VK, Mathew PJ, Hegde H. Efficacy of orally disintegrating ondansetron in preventing postoperative nausea and vomiting after laparoscopic cholecystectomy: a randomised, double-blind placebo controlled study. Anaesthesia 2009;64(6):595-600. [DOI: 10.1111/j.1365-2044.2008.05860.x] [PMID: 19453311 ] - DOI - PubMed
Gugale 2016 {published data only}
Guldogus 1994 {published data only}
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- Guldogus F, Sarihasan B, Esener Z, Karakaya D, Tur A, Ustun E. The effect of a single dose of ondansetron on postoperative nausea and vomiting. Turk Anesteziyoloji ve Reanimasyon 1994;22(2):77–80.
Gupta 2007 {published data only}
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- Gupta V, Wakhloo R, Lahori VU, Mahajan MK, Gupta SD. Prophylactic antiemetic therapy with ondansetron, granisetron and metoclopramide in patients undergoing laparoscopic cholecystectomy under general anaesthesia. Internet Journal of Anesthesiology 2007;14(1):1-6.
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- Gupta V, Wakhloo R, Mehta A, Gupta SD. Prophylactic antiemetic therapy with ondansetron, granisetron and metoclopramide in patients undergoing laparoscopic cholecystectomy under GA. JK Science 2008;10(2):74-7.
Gupta 2011 {published data only}
Gupta K 2014 {published data only}
Gupta Priyanka 2014 {published data only}
Gupta Pushplata 2014 {published data only}
Ha 2015 {published data only}
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- Ha SH, Kim H, Ju HM, Nam DJ, Min KT. Comparison of the antiemetic effect of ramosetron with ondansetron in patients undergoing microvascular decompression with retromastoid craniotomy: a preliminary report. Korean Journal of Anesthesiology 2015;68(4):386-91. [DOI: 10.4097/kjae.2015.68.4.386] [PMID: 26257852 ] - DOI - PMC - PubMed
Habib 2004 {published data only}
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- Habib AS, White WD, Eubanks S, Pappas TN, Gan TJ. A randomized comparison of a multimodal management strategy versus combination antiemetics for the prevention of postoperative nausea and vomiting. Anesthesia and Analgesia 2004;99(1):77-81. [PMID: ] - PubMed
Habib 2011 {published data only}
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- Habib AS, Keifer JC, Borel CO, White WD, Gan TJ. A comparison of the combination of aprepitant and dexamethasone versus the combination of ondansetron and dexamethasone for the prevention of postoperative nausea and vomiting in patients undergoing craniotomy. Anesthesia and Analgesia 2010;110(3 Suppl 1):436. [DOI: 10.1213/01.ANE.0000398215.59935.49] [PMID: 21081776 ] - DOI - PubMed
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- Habib AS, Keifer JC, Borel CO, White WD, Gan TJ. A comparison of the combination of aprepitant and dexamethasone versus the combination of ondansetron and dexamethasone for the prevention of postoperative nausea and vomiting in patients undergoing craniotomy. Anesthesia and Analgesia 2011;112(4):813-8. [DOI: 10.1213/ANE.0b013e3181ff47e2] [PMID: 21081776 ] - DOI - PubMed
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- NCT00734929. Aprepitant With Dexamethasone Versus Ondansetron With Dexamethasone for PONV Prophylaxis in Patients Having Craniotomy. clinicaltrials.gov/ct2/show/NCT00734929 (first received 14 August 2008).
Hammas 2002 {published data only}
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- Hammas B, Thörn SE, Wattwil M. Prophylactic treatment of PONV—a comparison of a combination of four antiemetics and a postoperative infusion of low-dose propofol. European Journal of Anaesthesiology 2000;17 Suppl 19:12.
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- Hammas B, Thörn SE, Wattwil M. Superior prolonged antiemetic prophylaxis with a four-drug multimodal regimen—comparison with propofol or placebo. Acta Anaesthesiologica Scandinavica 2002;46(3):232-7. [PMID: ] - PubMed
Hanaoka 2004 {published data only}
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- Hechler A, Naujoks F, Hopf HB. Routine use of the anti-emetic dehydrobenzperidol (DHBP) after elective surgery in adults is only effective and efficient in female patients. In: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie. Vol. 34. 1999:S115. - PubMed
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- Hechler A, Neumann S, Jehmlich M, Lange U, Hopf HB. A small dose of droperidol decreases postoperative nausea and vomiting in adults but cannot improve an already excellent patient satisfaction. Acta Anaesthesiologica Scandinavica 2001;45(4):501-6. [PMID: ] - PubMed
Hefni 2014 {published data only}
Hegde 2014 {published data only}
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- Hegde HV, Yaliwal VG, Annigeri RV, Sunilkumar K, Rameshkumar R, Rao PR. Efficacy of orally disintegrating film of ondansetron versus intravenous ondansetron in prophylaxis of postoperative nausea and vomiting in patients undergoing elective gynaecological laparoscopic procedures: a prospective randomised, double-blind placebo-controlled study. Indian Journal of Anaesthesia 2014;58(4):423-9. [DOI: 10.4103/0019-5049.138977] [PMID: ] - DOI - PMC - PubMed
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- Heinke W, Frank T, Meier P, Wiegel M, Korth D. Postoperative vomiting after pars plana vitrectomy. Anaesthesiologie und Reanimation 1996;21(2):47-50. [PMID: ] - PubMed
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- Helmers JH, Briggs L, Abrahamsson J, Soni J, Moodley J, Forrler M, et al. A single i.v. dose of ondansetron 8 mg prior to induction of anaesthesia reduces postoperative nausea and vomiting in gynaecological patients. Journal Canadien d'Anesthesie (Canadian Journal of Anaesthesia) 1993;40(12):1155-61. - PubMed
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- Helmy SA. Prophylactic anti-emetic efficacy of ondansetron in laparoscopic cholecystectomy under total intravenous anaesthesia. A randomised, double-blind comparison with droperidol, metoclopramide and placebo. Anaesthesia 1999;54(3):266-71. [PMID: ] - PubMed
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- Hemmati HR, Ghorbani R, Hossein-Zadeh B, Ebrahim-Zadeh H, Shakeri S. The effect of single dose of dexamethasone on postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Journal of Babol University of Medical Sciences 2014;16(11):15-21.
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Hessami 2012 {published data only}
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- IRCT138903033939N1. Comparison of the Effects of Dexamethasone and Granisetron in the Prevention of Nausea and Vomiting After Laparoscopic Cholecystectomy. who.int/trialsearch/Trial2.aspx?TrialID=IRCT138903033939N1 (first received 24 May 2010).
Ho 1990 {published data only}
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- Ho RT, Jawan B, Fung ST, Cheung HK, Lee JH. Electro-acupuncture and postoperative emesis. Anaesthesia 1990;45(4):327-9. [PMID: ] - PubMed
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Honkavaara 1996 {published data only}
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Hu 2017 {published data only}
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- ChiCTR-IPR-15005852. Observation of Granisetron and Different Doses of Palonosetron on the Prevention of Postoperative Nausea and Vomiting (PONV) for Eye enucleation and orbital hydroxyapatite implant surgery [who.int/trialsearch/Trial2.aspx?TrialID=ChiCTR-IPR-15005852]. (first received 15 January 2015).
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- Hu X, Tan F, Gong L. Higher dose of palonosetron versus lower dose of palonosetron plus droperidol to prevent postoperative nausea and vomiting after eye enucleation and orbital hydroxyapatite implant surgery: a randomized, double-blind trial. Drug design, Development and Therapy 2017;11:1465-72. [PMID: 28553076] - PMC - PubMed
Huang 2001 {published data only}
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- Huang JC, Shieh JP, Tang CS, Tzeng JI, Chu KS, Wang JJ. Low-dose dexamethasone effectively prevents postoperative nausea and vomiting after ambulatory laparoscopic surgery. Journal Canadien d'Anesthesie (Canadian Journal of Anaesthesia) 2001;48(10):973-7. [DOI: 10.1007/BF03016586] [PMID: 11698315 ] - DOI - PubMed
Huang 2016 {published data only}
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- Huang SH, Lu J, Gan HY, Li Y, Peng YG, Wang SK. Perineural dexamethasone does not enhance the analgesic efficacy of ultrasound-guided subcostal transversus abdominis plane block during laparoscopic cholecystectomy. Hepatobiliary and Pancreatic Diseases International 2016;15(5):540-5. [PMID: ] - PubMed
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- Ibrahim M, Eldesuky HI, Ibrahim TH. Oral olanzapine versus oral ondansetron for prevention of post-operative nausea and vomiting. A randomized, controlled study. Egyptian Journal of Anaesthesia 2013;29(2):89-95. [DOI: 10.1016/j.egja.2013.01.002] - DOI
Ionescu 2007 {published data only}
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- Ionescu DC, Hadade AI, Mocan TA, Margarit SD. The influence of a prophylactic dose of dexamethasone for postoperative nausea and vomiting on plasma interleukin concentrations after laparoscopic cholecystectomy: a randomised trial. European Journal of Anaesthesiology 2014;31(4):204-11. [DOI: 10.1097/EJA.0b013e3283642a01] [PMID: 23880908 ] - DOI - PubMed
Isik 2006 {published data only}
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- Jamil M, Gilani SM, Khan SA. Comparison of metoclopramide, prochlorperazine and placebo in prevention of postoperative nausea and vomiting (PONV) following tonsillectomy in young adults. Journal of Ayub Medical College, Abbottabad 2005;17(4):40-4. [PMID: ] - PubMed
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Janicki 2006 {published data only}
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Joo 2016 {published data only}
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Joris 2003 {published data only}
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Kaja 2014 {published data only}
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- Kaja S, Giri RS, Tugave DV, Iqbal M. A randomized clinical trial comparing the efficacy and safety of ramosetron versus ondansetron in patients undergoing abdominal surgery under general anesthesia. Saudi Journal of Anaesthesia 2014;8(1):59-63. [DOI: 10.4103/1658-354X.125938] [PMID: ] - DOI - PMC - PubMed
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- Kawano H, Matsumoto T, Hamaguchi E, Manabe S, Nakagawa M, Yamada A, et al. Antiemetic efficacy of combined aprepitant and dexamethasone in patients at high-risk of postoperative nausea and vomiting from epidural fentanyl analgesia. Minerva Anestesiologica 2015;81(4):362-8. [PMID: ] - PubMed
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Khafagy 2010 {published data only}
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- Khan M, Singh V, Kumar M, Singh B, Kapoor R, Bhatia V. Prophylactic antiemetic therapy using combinations of granisetron, dexamethasone and droperidol in patients undergoing laparoscopic cholecystectomy. Internet Journal of Anesthesiology 2008;21(1):1-10.
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- Kim SI, Kim SC, Nam SG, Kim YI. Antiemetic efficacy of prophylactic ondansetron in gynecologic patient using patient-controlled analgesia after surgery. Korean Journal of Anesthesiology 1999;37(6):1089-94.
Kim 2000 {published data only}
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- Kim CS, Ro YJ. Postoperative antiemetic effect of ondansetron and droperidol in female patients undergoing breast surgery. Korean Journal of Anesthesiology 2000;39(5):686-90.
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- Kim DH, Cho DH, Park CH. The effect of timing of ondansetron administration on nausea and vomiting during intravenous patient-controlled analgesia. Korean Journal of Anesthesiology 2001;41(1):33-8.
Kim 2005a {published data only}
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- Kim SI, Park EJ, Jung SH, You SH, Kim CS. Preventive effect of intravenous ondansetron on postoperative nausea and vomiting related to epidural morphine after abdominal surgery. Korean Journal of Anesthesiology 2005;49(2):222-6.
Kim 2005b {published data only}
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- Kim SI, Lee SC, Ok SY, Kim SC. Ondansetron reduces postoperative nausea and vomiting after a laparoscopic cholecystectomy. Korean Journal of Anesthesiology 2005;49(3):365-9.
Kim 2007 {published data only}
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- Kim HJ, Kwak KH. Efficacy of ramosetron for the prevention of nausea and vomiting after thyroidectomy. Korean Journal of Anesthesiology 2007;53(4):425-9. [DOI: 10.4097/kjae.2007.53.4.425] - DOI
Kim 2009 {published data only}
Kim 2012 {published data only}
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- Kim YY, Song DU, Lee KH, Lee IJ, Song JW, Lim JH. Comparison of palonosetron with ondansetron in preventing postoperative nausea and vomiting after thyroidectomy during a 48-hour period. Anesthesia and Pain Medicine 2012;7(4):312-6.
Kim 2015 {published data only}
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- KCT0000183. Efficacy of Ramosetron and Palonosetron on Patient-controlled Analgesia Related Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery. who.int/trialsearch/Trial2.aspx?TrialID=KCT0000183 (first received 8 September 2011).
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- Kim SH, Oh CS, Lee SJ. Efficacy of palonosetron and ramosetron on postoperative nausea and vomiting related to intravenous patient-controlled analgesia with opioids after gynecological laparoscopic surgery (double-blinded prospective randomized controlled trial). Journal of Anesthesia 2015;29(4):585-92. [DOI: 10.1007/s00540-015-1981-4] [PMID: 25735497 ] - DOI - PubMed
Kim JE 2005 {published data only}
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- Kim JE, Lee CB, Kim SC, Kim SI, Ok SY. Ramosetron compared with granisetron for the prevention of postoperative nausea and vomiting following general anesthesia for breast mass excision. Korean Journal of Anesthesiology 2005;49(4):507-12.
Kim SH 2013 {published data only}
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- Kim SH, Hong JY, Kim WO, Kil HK, Karm MH, Hwang JH. Palonosetron has superior prophylactic antiemetic efficacy compared with ondansetron or ramosetron in high-risk patients undergoing laparoscopic surgery: a prospective, randomized, double-blinded study. Korean Journal of Anesthesiology 2013;64(6):517-23. [PMID: 23814652 ] - PMC - PubMed
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Kim WJ 2013 {published data only}
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- ACTRN12612000757819. Ramosetron, Low Dose Midazolam, and Their Combination for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Thyroidectomy. who.int/trialsearch/Trial2.aspx?TrialID=ACTRN12612000757819 (first received 16 July 2012).
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- Kim WJ, Kang H, Shin HY, Baek CW, Jung YH, Woo YC, et al. Ramosetron, midazolam, and combination of ramosetron and midazolam for prevention of postoperative nausea and vomiting: a prospective, randomized, double-blind study. Journal of International Medical Research 2013;41(4):1203-13. [DOI: 10.1177/0300060513485864] [PMID: ] - DOI - PubMed
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Kizilcik 2017 {published data only}
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- Kizilcik N, Bilgen S, Menda F, Türe H, Aydın B, Kaspar EC, et al. Comparison of dexamethasone-dimenhydrinate and dexamethasone-ondansetron in prevention of nausea and vomiting in postoperative patients. Aesthetic Plastic Surgery 2017;41(1):204-10. [PMID: 28039501 ] - PubMed
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Kizilkaya 2004 {published data only}
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- Kizilkaya M, Yildirim OS, Dogan N, Kursad H, Okur A. Analgesic effects of intraarticular sufentanil and sufentanil plus methylprednisolone after arthroscopic knee surgery. Anesthesia and Analgesia 2004;98(4):1062-5. [PMID: ] - PubMed
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Koo 2001 {published data only}
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- Kumar A, Agarwal M, Bhattacharya A. Effect of ondansetron and metoclopramide on vigilance, cognition and recovery time following major gynaecological surgery. Journal of Anaesthesiology, Clinical Pharmacology 1996;12(1):35-8.
Kumar 2013 {published data only}
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- Kumar A, Patodia M, Pandove PK, Sharda VK. A randomized, placebo controlled study evaluating preventive role of ondansetron, dexamethasone and ondansetron plus dexamethasone for postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic cholecystectomy. Journal International Medical Sciences Academy 2013;26(4):217-8.
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Kyokong 1999 {published data only}
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- Kyokong O, Somboonviboon W, Visalyaputra S, Pausawadi S, Saratan P, Vongvises P. Comparison of ondansetron and placebo for preventing postoperative nausea and emesis in gastrointestinal tract surgery: a multicenter randomized controlled trial. Journal of the Medical Association of Thailand 1999;82(2):173-7. [PMID: ] - PubMed
Laha 2013 {published data only}
Lahsaei 2012 {published data only}
Laiq 2005 {published data only}
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Lee 2000 {published data only}
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- Lee TH, Lin CR, Lee TC, Buerkle H, Hsu TY, Mao CC, et al. Failure of prevention against postoperative vomiting by ondansetron or prochlorperazine in patients undergoing gynecological laparoscopy. Acta Anaesthesiologica Sinica 2000;38(4):201-5. [PMID: ] - PubMed
Lee 2003 {published data only}
Lee 2006 {published data only}
Lee 2008a {published data only}
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- Lee HJ, Kwon JY, Shin SW, Kim CH, Baek SH, Baik SW, et al. Preoperatively administered ramosetron oral disintegrating tablets for preventing nausea and vomiting associated with patient-controlled analgesia in breast cancer patients. European Journal of Anaesthesiology 2008;25(9):756-62. [DOI: 10.1017/S0265021508004262] [PMID: 18426627 ] - DOI - PubMed
Lee 2008b {published data only}
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- Lee HJ, Shin CS, Choi BS, Yoon JY, Kwon JY, Kim HK. Effect of oral ramosetron for postoperative nausea and vomiting in surgical patients using patient controlled analgesia. Korean Journal of Anesthesiology 2008;54(1):63-8. [DOI: 10.4097/kjae.2008.54.1.63] - DOI
Lee 2012 {published data only}
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- Lee SJ, Lee SM, Kim SI, Ok SY, Kim SH, Park SY, et al. The effect of aprepitant for the prevention of postoperative nausea and vomiting in patients undergoing gynecologic surgery with intravenous patient controlled analgesia using fentanyl: aprepitant plus ramosetron vs ramosetron alone. Korean Journal of Anesthesiology 2012;63(3):221-6. [PMID: ] - PMC - PubMed
Lee 2014 {published data only}
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- Lee KH, Rim SK, Lee JY, Lee SY, Lee SN, Lee EJ, et al. Effects of pretreatment with intravenous palonosetron for propofol-remifentanil-based anesthesia in breast and thyroid cancer surgery: a double-blind, randomized, controlled study. Korean Journal of Anesthesiology 2014;67(1):13-9. [DOI: 10.4097/kjae.2014.67.1.13] [PMID: 25097733 ] - DOI - PMC - PubMed
Lee D 2009 {published data only}
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- Lee D, Kim JY, Shin JW, Ku CH, Park YS, Kwak HJ. The effect of oral and IV ramosetron on postoperative nausea and vomiting in patients undergoing gynecological laparoscopy with total intravenous anesthesia. Journal of Anesthesia 2009;23(1):46-50. [DOI: 10.1007/s00540-008-0693-4] [PMID: 19234822 ] - DOI - PubMed
Lee DC 2011 {published data only}
Lee HS 2004 {published data only}
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- Lee HS, Song JH, Kim TJ, Han JU, Lim HK, Shin H. Comparison of dexamethasone and ondansetron for the prevention of nausea and vomiting using intravenous patient-controlled analgesia after gynecologic surgery. Korean Journal of Anesthesiology 2004;47(5):726-31.
Lee IH 2007 {published data only}
Lee JW 2011 {published data only}
Lee MJ 2015 {published data only}
Lee SY 2001 {published data only}
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- Lee SY, Jung SM, Han SG, Won JJ, Yu ES, Suh CK. A comparison of the efficacy and safety of tropisetron and tropisetron plus dexamethasone as antiemetics for elective thyroidectomy. Korean Journal of Anesthesiology 2001;40(4):496-502.
Lee SY 2002 {published data only}
Lee WS 2015 {published data only}
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- Lee WS, Lee KB, Lim S, Chang YG. Comparison of palonosetron, granisetron, and ramosetron for the prevention of postoperative nausea and vomiting after laparoscopic gynecologic surgery: a prospective randomized trial. BMC Anesthesiology 2015;15:121. [DOI: 10.1186/s12871-015-0102-0] [PMID: ] - DOI - PMC - PubMed
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Lee Y 2001 {published data only}
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- Lee Y, Lin PC, Lai HY, Huang SJ, Lin YS, Cheng CR. Prevention of PONV with dexamethasone in female patients undergoing desflurane anesthesia for thyroidectomy. Acta Anaesthesiologica Sinica 2001;39(4):151-6. [PMID: ] - PubMed
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- Lee Y, Lai HY, Lin PC, Lin YS, Huang SJ, Shyr MH. A dose ranging study of dexamethasone for preventing patient-controlled analgesia-related nausea and vomiting: a comparison of droperidol with saline. Anesthesia and Analgesia 2004;98(4):1066-71. [PMID: 15041600] - PubMed
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- Li ZH, Liu D, He ZJ, Fan ZY. Influence of dexamethasone on the incidence of postoperative nausea and vomiting in breast cancer patients with neoadjuvant chemotherapy. Beijing Da Xue Xue Bao. Yi Xue Ban [Journal of Peking University. Health Sciences] 2015;47(4):685-9. [PMID: ] - PubMed
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- Li ZH, Liu D, He ZJ, Fan ZY. Influence of dexamethasone on the incidence of postoperative nausea and vomiting in breast cancer patients with neoadjuvant chemotherapy. Beijing Da Xue Xue Bao. Yi Xue Ban [Journal of Peking University. Health Sciences] 2015;47(4):685-9. [PMID: ] - PubMed
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- Lim CS, Ko Y-K, Kim Y-H, Park S-I, Kim, J-K, Kim M-J. Efficacy of the oral neurokinin-1 receptor antagonist aprepitant administered with ondansetron for the prevention of postoperative nausea and vomiting. Korean Journal of Anesthesiology 2013;64(3):212-7. [DOI: 10.4097/kjae.2013.64.3.212] - DOI - PMC - PubMed
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Liu 2001 {published data only}
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Long 2014 {published data only}
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Mathia 1988 {published data only}
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Matsota 2015 {published data only}
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- Matsota P, Angelidi M, Pandazi A, Tzirogiannis KN, Panoutsopoulos GI, Kostopanagiotou G. Ondansetron-droperidol combination vs. ondansetron or droperidol monotherapy in the prevention of postoperative nausea and vomiting. Archives of Medical Science 2015;11(2):362-70. [DOI: 10.5114/aoms.2015.50968] [PMID: 25995753 ] - DOI - PMC - PubMed
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- Murphy G, Sherwani SS, Szokol J, Avram MJ, Patel K. The effect of small-dose dexamethasone on clinical recovery after cardiac surgery. Anesthesia and Analgesia 2011;112(5 Suppl 1):S-40. [DOI: 10.1213/01.ANE.0000403380.73932.6a] - DOI
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Naghibi 2015 {published data only}
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Nielsen 2015 {published data only}
-
- NCT01953978. The Effect of Dexamethasone in Combination With Paracetamol and Ibuprofen on Postoperative Pain After Spine Surgery [The Effect of Dexamethasone in Combination With Paracetamol and Ibuprofen as Adjuvant, Postoperative Pain After Herniated Disc Surgery]. clinicaltrials.gov/ct2/show/NCT01953978 (first received 1 October 2013).
-
- Nielsen RV, Siegel H, Fomsgaard JS, Andersen JD, Martusevicius R, Mathiesen O, et al. Preoperative dexamethasone in combination with perioperative paracetamol and ibuprofen reduces pain after lumbar disc surgery: a randomized, blinded placebo-controlled trial. In: Acta Anaesthesiologica Scandinavica. Conference: 33rd Congress of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine. Reykjavik Iceland. Conference start: 20150610. Conference end: 20150610. Conference publication: (var.pagings). Vol. 59. 2015:3-4. [DOI: 10.1111/aas.12556] - DOI
-
- Nielsen RV, Siegel H, Fomsgaard JS, Andersen JD, Martusevicius R, Mathiesen O, et al. Preoperative dexamethasone reduces acute but not sustained pain after lumbar disk surgery: a randomized, blinded, placebo-controlled trial. Pain 2015;156(12):2538-44. [DOI: 10.1097/j.pain.0000000000000326] [PMID: ] - DOI - PubMed
NKO101287 {published data only}
-
- EUCTR2004-001021-22-FI. A Multicentre, Randomised, Double-blind, Double-dummy, Placebo-controlled, Parallel Group, Phase II Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Oral (25 mg) and Intravenous (3 mg and 18 mg) Formulations of the Neurokinin-1 Receptor Antagonist, GW597599, When Administered With Intravenous Ondansetron Hydrochloride for the Prevention of Post-operative Nausea and Vomiting and Post-discharge Nausea and Vomiting in Female Subjects With Known Risk Factors for PONV. who.int/trialsearch/Trial2.aspx?TrialID=EUCTR2004-001021-22-FI (first received 11 November 2004).
-
- NCT00600990. Study of an NK-1 Anti-Emetic Medication for the Prevention of Post-Operative Nausea and Vomiting in Female Patients [Phase II Multicenter, Dose Ranging Study on the Safety and Antiemetic Efficacy of One Day Intraveous Dosing of GW597599 Administered With Ondansetron HCL in a Female Subject Undergoing Surgical Procedure of High Emetogenic Risk]. clinicaltrials.gov/ct2/show/NCT00600990 (first received 25 January 2008).
-
- NKO101287. The purpose of this study is to determine the effectiveness of this medication in preventing nausea and vomiting in female patients at risk for post-operative nausea and vomiting (PONV). www.gsk-studyregister.com/study?uniqueStudyId=NKO101287 (assessed 06 December 2018).
NKT102245 {published data only}
-
- EUCTR2004-000369-37. A Multicentre, Randomised, Double-blind, Placebo-controlled, Parallel Group Study to Evaluate the Safety and Efficacy of Oral Dosing With GW679769 (50 mg or 150 mg) for 3 Consecutive Days. www.clinicaltrialsregister.eu/ctr-search/search?query=2004-000369-37 (first received 22 February 2005).
-
- NCT00274690. Post-Operative Nausea and Vomiting Study in Female Patients [A Multicenter, Randomised, Double-blind, Placebo-controlled, Parallel Group, Phase II Study to Evaluate the Safety and Efficacy of Oral Dosing With GW679769 (50 mg or 150 mg) for Three Consecutive Days When Administered With a Single Intravenous Dose of Ondansetron Hydrochloride for the Prevention of Post-operative Nausea and Vomiting and Post-discharge Nausea and Vomiting in Female Subjects With Known Risk Factors for Post-operative Nausea and Vomiting Who Are Undergoing Laparoscopic/Laparotomic Surgical Procedures Associated With an Increased Emetogenic Risk]. clinicaltrials.gov/ct2/show/NCT00274690 (first received 11 January 2006).
-
- NKT102245. The primary purpose of this study is to determine an effective dose of this NK-1 anti-emetic medication to prevent nausea and vomiting in females after surgery. www.gsk-studyregister.com/study?uniqueStudyId=NKT102245 (accessed 06 December 2018).
NKT102260 {published data only}
-
- EUCTR2004-000370-31. A Multicentre, Randomised, Double-blind, Placebo-controlled, Dose-ranging, Parallel Group Phase II Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of the Oral Neurokinin-1 Receptor Antagonist. www.clinicaltrialsregister.eu/ctr-search/search?query=2004-000370-31 (first received 25 March 2005).
-
- NCT00108095. A Study to Evaluate an NK-1 Antiemetic for the Prevention of Post Operative Nausea and Vomiting [A Multicenter, Randomized, Double-blind, Placebo-controlled, Dose-ranging, Parallel Group Phase II Study to Evaluate the Safety, Efficacy and Pharmacokinetics of the Oral Neurokinin-1 Receptor Antagonist, GW679769, When Administered With Intravenous Ondansetron Hydrochloride for the Prevention of Post-operative Nausea and Vomiting (PONV) and Post-discharge Nausea and Vomiting (PDNV) in Female Subjects With Known Risk Factors for PONV Who Are Undergoing Surgical Procedures Associated With an Increased Emetogenic Risk]. clinicaltrials.gov/ct2/show/NCT00108095 (first received 14 April 2005).
-
- NKT102260. This study is looking at a range of doses of this NK-1 receptor antagonist drug, for both safety and effectiveness in prevention PONV. www.gsk-studyregister.com/study?uniqueStudyId=NKT102260 (accessed 06 December 2018).
NKT102552 {published data only}
-
- EUCTR2005-005855-16. A Phase III Multicenter, Randomized, Double-blind, Parallel Group Study to Evaluate the Safety and Efficacy of the 30 mg Intravenous Formulation of the Neurokinin-1 Receptor Antagonist GW679769. www.clinicaltrialsregister.eu/ctr-search/trial/2005-005855-16/BE (first received 24 February 2006).
-
- NCT00334152. Casopitant and ZOFRAN to Prevent Post Operative Nausea and Vomiting In Women [A Phase III Multicenter, Randomized, Double-blind, Parallel Group Study to Evaluate the Safety and Efficacy of the 30 mg Intravenous Formulation of the Neurokinin-1 Receptor Antagonist GW679769 for Prevention of Postoperative Nausea and Vomiting in Female Subjects at High Risk for Emesis]. clinicaltrials.gov/ct2/show/NCT00334152 (first received 6 June 2006).
-
- NKT102552. This study is being conducted to see if adding GW679769 (casopitant) to ZOFRAN will significantly decrease the number of patients who experience nausea and vomiting after surgery. www.gsk-studyregister.com/study?uniqueStudyId=NKT102552 (accessed 06 December 2018).
Oksuz 2007 {published data only}
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- Oksuz H, Zencirci B, Ezberci M. Comparison of the effectiveness of metoclopramide, ondansetron, and granisetron on the prevention of nausea and vomiting after laparoscopic cholecystectomy. Journal of Laparoendoscopic and Advanced Surgical Techniques 2007;17(6):803-8. [PMID: ] - PubMed
Olajumoke 2013 {published data only}
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- Olajumoke TO, Afolayan JM, Fashanu AO, Adekunle MA. Single dose of dexamethasone for prevention of nausea and vomiting after major gynaecological surgery. Nigerian Journal of Medicine: Journal of the National Association of Resident Doctors of Nigeria 2013;22(3):207-11. [PMID: ] - PubMed
Olanders 2014 {published data only}
Olatosi 2008 {published data only}
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- Olatosi OJ, Kushimo O, Okeke C, Oriyomi O, Ajayi GO. Antiemetic prophylaxis with promethazine or ondansetron in major gynaecological surgery. Southern African Journal of Anaesthesia and Analgesia 2008;14(6):39-42.
Ozdamar 2006 {published data only}
-
- Ozdamar D, Baykara N, Canatay H, Solak M, Toker K. Comparison of ondansetron-dexamethasone combination and ondansetron or dexamethasone for prevention of postoperative nausea and vomiting. Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi 2006;34(1):35-42.
Ozmen 2002 {published data only}
-
- Ozmen S, Yavuz L, Ceylan BG, Tarhan O, Aydin C. Comparison of granisetron with granisetron plus droperidol combination prophylaxis in post-operative nausea and vomiting after laparoscopic cholecystectomy. Journal of International Medical Research 2002;30(5):520-4. [DOI: 10.1177/147323000203000508] [PMID: 12449522 ] - DOI - PubMed
Ozunlu 2005 {published data only}
-
- Ozunlu O, Karaman S, Firat V. Anaesthetic technique and postoperative nausea, vomiting and cognitive functions in outpatients undergoing gynecologic laparoscopic surgery. Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi 2005;33(3):209-16.
Paech 1995 {published data only}
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- Paech MJ, Pavy TJ, Evans SF. Single-dose prophylaxis for postoperative nausea and vomiting after major abdominal surgery: ondansetron versus droperidol. Anaesthesia and Intensive Care 1995;23(5):548-54. [PMID: ] - PubMed
Paech 2002 {published data only}
-
- Paech MJ, Lee BH, Evans SF. The effect of anaesthetic technique on postoperative nausea and vomiting after day-case gynaecological laparoscopy. Anaesthesia and Intensive Care 2002;30(2):153-9. [PMID: ] - PubMed
Paech 2003 {published data only}
-
- Paech MJ, Rucklidge MW, Banks SL, Gurrin LC, Orlikowski CE, Pavy TJ. The efficacy and cost-effectiveness of prophylactic 5-hydroxytryptamine3 receptor antagonists: tropisetron, ondansetron and dolasetron. Anaesthesia and Intensive Care 2003;31(1):11-7. - PubMed
PALO‐04‐07 {published data only}
-
- PALO-04-07. A Randomized, Double-blind, Multicenter, Parallel Group, Balanced, Stratified Phase 3 Study to Evaluate the Efficacy and the Safety of Single IV Doses of Palonosetron 0.025 mg, 0.050 mg, and 0.075 mg versus Placebo to Prevent Postoperative Nausea and Vomiting Following Elective Gynecologic or Breast Surgery. www.clinicaltrialsregister.eu/ctr-search/search?query=2005-000298-23 (first received 31 May 2005).
Pan 2008 {published data only}
-
- Pan PH, Lee SC, Harris LC. Antiemetic prophylaxis for postdischarge nausea and vomiting and impact on functional quality of living during recovery in patients with high emetic risks: a prospective, randomized, double-blind comparison of two prophylactic antiemetic regimens. Anesthesia and Analgesia 2008;107(2):429-38. [DOI: 10.1213/ane.0b013e318172f992] [PMID: 18633020 ] - DOI - PubMed
Pandit 1989 {published data only}
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- Pandit SK, Kothary SP, Pandit UA, Randel G, Levy L. Dose-response study of droperidol and metoclopramide as antiemetics for outpatient anesthesia. Anesthesia and Analgesia 1989;68(6):798-802. [PMID: 2525354] - PubMed
Papadima 2013 {published data only}
-
- Papadima A, Gourgiotis S, Lagoudianakis E, Pappas A, Seretis C, Antonakis PT, et al. Granisetron versus tropisetron in the prevention of postoperative nausea and vomiting after total thyroidectomy. Saudi Journal of Anaesthesia 2013;7(1):68-74. [DOI: 10.4103/1658-354X.109817] [PMID: 23717236] - DOI - PMC - PubMed
Papadimitriou 2001 {published data only}
-
- Papadimitriou L, Livanios S, Katsaros G, Hassiakos D, Koussi T, Demesticha T. Prevention of postoperative nausea and vomiting after laparoscopic gynaecological surgery. Combined antiemetic treatment with tropisetron and metoclopramide vs. metoclopramide alone. European Journal of Anaesthesiology 2001;18(9):615-9. [PMID: ] - PubMed
Park 2006 {published data only}
-
- Park HH, Park KS, Lee SY, Cho OG, Kim JH, Kim JS. The effects of prophylactic metoclopramide and induction with propofol on postoperative nausea and vomiting. Korean Journal of Anesthesiology 2006;50(2):179-83. - PubMed
Park 2011 {published data only}
-
- Park SK, Cho EJ. A randomized, double-blind trial of palonosetron compared with ondansetron in preventing postoperative nausea and vomiting after gynaecological laparoscopic surgery. Journal of International Medical Research 2011;39(2):399-407. [DOI: 10.1177/147323001103900207] [PMID: 21672343 ] - DOI - PubMed
Park 2012 {published data only}
-
- Park JW, Jun JW, Lim YH, Lee SS, Yoo BH, Kim KM, et al. The comparative study to evaluate the effect of palonosetron monotherapy versus palonosetron with dexamethasone combination therapy for prevention of postoperative nausea and vomiting. Korean Journal of Anesthesiology 2012;63(4):334-9. [DOI: 10.4097/kjae.2012.63.4.334] [PMID: 23115686] - DOI - PMC - PubMed
Park 2013 {published data only}
-
- NCT01476280. Palonosetron Versus Ramosetron for the Prevention of Postoperative Nausea and Vomiting [A Randomized Double Blind Study to Evaluate Efficacy of Ramosetron and Palonosetron for Prevention of Postoperative Nausea and Vomiting After Gynaecological Laparoscopic Surgery]. clinicaltrials.gov/ct2/show/NCT01476280 (first received 22 November 2011).
-
- Park SK, Cho EJ, Kang SH, Lee YJ, Kim DA. A randomized, double-blind study to evaluate the efficacy of ramosetron and palonosetron for prevention of postoperative nausea and vomiting after gynecological laparoscopic surgery. Korean Journal of Anesthesiology 2013;64(2):133-7. [DOI: 10.4097/kjae.2013.64.2.133] [PMID: 23459596 ] - DOI - PMC - PubMed
Pascucci 1996 {published data only}
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- Pascucci G, Palmieri V, Miranda G, Buccarella A. Tropisetron versus ondansetron in the prevention and control of postoperative nausea and vomiting (PONV). Acta Anaesthesiologica Italica 1996;47(3):173-7.
Patterson 1991 {published data only}
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- Patterson KW, Armstrong C, Timon D, O’Toole D, Keane PW. The value of buccal prochlorperazine in the prevention of post-operative nausea and vomiting. Journal of the Irish Colleges of Physicians and Surgeons 1991;20(3):200-2.
Patterson 1993 {published data only}
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- Patterson KW, Armstrong C, Timon D, O'Toole D, Keane PW. Buccal prochlorperazine as an antiemetic for day care surgery. Irish Medical Journal 1993;86(6):186-8. [PMID: ] - PubMed
Patton 1974 {published data only}
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- Patton CM Jr, Moon MR, Dannemiller FJ. The prophylactic antiemetic effect of droperidol. Anesthesia and Analgesia 1974;53(3):361-4. - PubMed
Pawar 2008 {published data only}
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- Pawar AN, Sarkar M, Dewoolkar L. Comparative study of single dose intravenous dexamethasone, ondansetron and ondansetron plus dexamethasone as prophylactic anti-emetic therapy in patients undergoing laparascopic gynaecological surgery. Internet Journal of Anesthesiology 2008;19(2):1-13.
Pearman 1994 {published data only}
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- Pearman MH. Single dose intravenous ondansetron in the prevention of postoperative nausea and vomiting. Anaesthesia 1994;49(1):11-5. [PMID: ] - PubMed
Peixoto 2000 {published data only}
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- Peixoto AJ, Peixoto Filho AJ, Leães LF, Celich MF, Barros MA. Efficacy of prophylactic droperidol, ondansetron or both in the prevention of postoperative nausea and vomiting in major gynaecological surgery. A prospective, randomized, double-blind clinical trial. European Journal of Anaesthesiology 2000;17(10):611-5. [PMID: ] - PubMed
Perez Ascencio 1992 {published data only}
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- Perez-Ascencio RE, Terrones-Vila JA, Calderon-Mancera M. A comparative study of droperidol, difenidol, metoclopramide and placebo for the control of post-operative nausea and vomiting. Revista Mexicana de Anestesiologia 1992;15(4):160-4.
Perez Garcia 2000 {published data only}
-
- Perez Garcia A, Cruz Anguiano V. Ondansetron vs. metoclopramide for post operative nausea and vomiting prevention. Revista Mexicana de Anestesiologia 2000;23(4):149-54.
Pertusa 1996 {published data only}
-
- Pertusa V, Bellver J, Marqués A, Onrubia X, Viñals MP, Sanmiguel G, et al. Antiemetic prophylaxis after laparoscopic cholecystectomy: comparative study of dehydrobenzperidol, metoclopramide, ondansetron and placebo. Revista Espanola de Anestesiologia y Reanimacion 1996;43(7):239-42. [PMID: ] - PubMed
Philip 2000 {published data only}
-
- Philip BK, McLeskey CH, Chelly JE, McKenzie R, Kovac AL, Diemunsch P, et al. Erratum: Pooled analysis of three large clinical trials to determine the optimal dose of dolasetron mesylate needed to prevent postoperative nausea and vomiting (Journal of Clinical Anesthesia (2000) 12 (1-8)). Journal of Clinical Anesthesia 2000;12(7):577-8. [DOI: 10.1016/S0952-8180(00)00198-7] - DOI - PubMed
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- Philip BK, McLeskey CH, Chelly JE, McKenzie R, Kovac AL, Diemunsch P, et al. Pooled analysis of three large clinical trials to determine the optimal dose of dolasetron mesylate needed to prevent postoperative nausea and vomiting. Journal of Clinical Anesthesia 2000;12(1):1-8. [PMID: ] - PubMed
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- Philip BK, Pearman MH, Kovac AL, Chelly JE, Wetchler BV, McKenzie R, et al. Dolasetron for the prevention of postoperative nausea and vomiting following outpatient surgery with general anaesthesia: a randomized, placebo-controlled study. The Dolasetron PONV Prevention Study Group. European Journal of Anaesthesiology 2000;17(1):23-32. [PMID: ] - PubMed
Phillips 1993 {published data only}
-
- Phillips S, Ruggier R, Hutchinson SE. Zingiber officinale (ginger) - an antiemetic for day case surgery. Anaesthesia 1993;48(8):715-7. [PMID: ] - PubMed
Piper 2003 {published data only}
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- Piper SN, Triem JG, Röhm KD, Kranke P, Maleck WH, Boldt J. Prevention of post-operative nausea and vomiting. Randomised comparison of dolasetron versus dolasetron plus dexamethasone. Anaesthetist 2003;52(2):120-6. [PMID: 12624696 ] - PubMed
Ploner 1997 {published data only}
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- Ploner F, Kainzwaldner A. Evaluation of the administration time of ondansetron, a preventive for postoperative nausea and vomiting: prospective, randomized, double-blind study in 120 patients. Anaesthetist 1997;46(7):583-7. [PMID: 9304358 ] - PubMed
Prescott 1976 {published data only}
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- Prescott RJ, Espley AJ, Davie IT, Slawson KB, Ruckley CV. Double-blind clinical trial of anaesthetic premedication for use in major day surgery. Lancet 1976;1(7970):1148-50. [PMID: 58198] - PubMed
Principi 1996 {published data only}
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- Principi F, Di AP, Sofra M, Salerno S, Aloe L. Intravenous ondansetron in the prophylactic treatment of postoperative nausea and vomiting in gynaecological surgery. Acta Anaesthesiologica Italica 1996;47(2):147-56.
Pueyo 1996 {published data only}
-
- Pueyo FJ, Carrascosa F, Lopez L, Iribarren MJ, García-Pedrajas F, Saez A. Combination of ondansetron and droperidol in the prophylaxis of postoperative nausea and vomiting. Anesthesia and Analgesia 1996;83(1):117-22. [PMID: ] - PubMed
Purhonen 1997 {published data only}
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- Purhonen S, Kauko M, Koski EM, Nuutinen L. Comparison of tropisetron, droperidol, and saline in the prevention of postoperative nausea and vomiting after gynecologic surgery. Anesthesia and Analgesia 1997;84(3):662-7. [PMID: ] - PubMed
Purhonen 2006a {published data only}
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- Purhonen S, Niskanen M, Wüstefeld M, Hirvonen E, Hynynen M. Supplemental 80% oxygen does not attenuate post-operative nausea and vomiting after breast surgery. Acta Anaesthesiologica Scandinavica 2006;50(1):26-31. [PMID: 16451147 ] - PubMed
Purhonen 2006b {published data only}
Quan 2007 {published data only}
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- Quan X, Ye TH, Zhu B. A randomized double-blind study of prevention of postoperative nausea and vomiting with ondansetron, tropisetron, or granisetron in patients undergoing general anesthesia. Acta Academiae Medicinae Sinicae 2007;29(1):107-10. [PMID: ] - PubMed
Quan 2011 {published data only}
-
- Quan X, Zhu B, Ye TH. Preventive efficacy of ondansetron and granisetron for postoperative nausea and vomiting in high-risk patients. Acta Academiae Medicinae Sinicae 2011;33(4):445-8. [PMID: 21906457 ] - PubMed
Quan 2014 {published data only}
Quaynor 2002 {published data only}
-
- Quaynor H, Raeder JC. Incidence and severity of postoperative nausea and vomiting are similar after metoclopramide 20 mg and ondansetron 8 mg given by the end of laparoscopic cholecystectomies. Acta Anaesthesiologica Scandinavica 2002;46(1):109-13. [PMID: ] - PubMed
Rajeeva 1999 {published data only}
Raphael 1993 {published data only}
-
- Raphael JH, Norton AC. Antiemetic efficacy of prophylactic ondansetron in laparoscopic surgery: randomized, double-blind comparison with metoclopramide. British Journal of Anaesthesia 1993;71(6):845-8. [PMID: ] - PubMed
Reeve 2005 {published data only}
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- Reeve BK, Cook DJ, Babineau D, Scholes LC, Buckley DN. Prophylactic diclectin reduces the incidence of postoperative vomiting. Journal Canadien d'Anesthésie [Canadian Journal of Anaesthesia] 2005;52(1):55-61. [PMID: ] - PubMed
Reihner 2000 {published data only}
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- Reihnér E, Grunditz R, Giesecke K, Gustafsson LL. Postoperative nausea and vomiting after breast surgery: efficacy of prophylactic ondansetron and droperidol in a randomized placebo-controlled study. European Journal of Anaesthesiology 2000;17(3):197-203. [PMID: 10758471] - PubMed
Reinhart 1994 {published data only}
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- Reinhart DJ, Klein KW, Schroff E. Transdermal scopolamine for the reduction of postoperative nausea in outpatient ear surgery: a double-blind, randomized study. Anesthesia and Analgesia 1994;79(2):281-4. [PMID: ] - PubMed
Rennemo 1982 {published data only}
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- Rennemo F, Larsen R, Breivik H. Avoiding psychic adverse effects during induction of neurolept anaesthesia with levomepromazine. A double-blind study of levomepromazine and droperidol. Acta Anaesthesiologica Scandinavica 1982;26(2):108-11. [PMID: ] - PubMed
Rettori 2011 {published data only}
-
- NCT00888303. Single Dose Steroid Before Thyroidectomy for Benign Disease to Improve Postoperative Nausea, Pain, and Vocal Function [Randomized Controlled Trial on Efficacy of Preemptive 8 mg of Dexamethasone for Reducing Pain and Postoperative Nausea and Vomit After Thyroidectomy for Benign Disease]. clinicaltrials.gov/ct2/show/NCT00888303 (first received 27 April 2009).
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- Rettori M, Feroci F, Borrelli A, Ottaviano A, Coppola A, Castagnoli A, et al. A single effective way to reduce post-thyroidectomy discomfort: a clinical trial. Minerva Chirurgica 2011;66(3):197-205. [PMID: ] - PubMed
Rho 2001‐1 {published data only}
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- Rho SY, Choi SJ. The effects of propofol anesthesia or prophylactic droperidol on postoperative nausea and vomiting in patients undergoing a gynecologic laparoscopy. Korean Journal of Anesthesiology 2001;40(3):348-58.
Rho 2001‐2 {published data only}
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- Rho SY, Choi SJ. The effects of propofol anesthesia or prophylactic droperidol on postoperative nausea and vomiting in patients undergoing a gynecologic laparoscopy. Korean Journal of Anesthesiology 2001;40(3):348-58.
Riley 1998 {published data only}
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- Riley TJ, McKenzie R, Trantisira BR, Hamilton DL. Droperidol-ondansetron combination versus droperidol alone for postoperative control of emesis after total abdominal hysterectomy. Journal of Clinical Anesthesia 1998;10(1):6-12. [PMID: ] - PubMed
Rimaitis 2010 {published data only}
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- Rimaitis K, Svitojūte A, Macas A. The influence of dexamethasone and ketolgan on postoperative nausea and vomiting and estimation of risk factors in women undergoing gynecologic laparoscopic surgeries. Medicina 2010;46(4):261-7. [PMID: 20571294] - PubMed
Rodrigo 1994 {published data only}
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- Rodrigo MR, Campbell RC, Chow J, Tong CK, Hui E, Lueveswanij S. Ondansetron for prevention of postoperative nausea and vomiting following minor oral surgery: a double-blind randomized study. Anaesthesia and Intensive Care 1994;22(5):576-9. [PMID: ] - PubMed
Rodrigo 1996 {published data only}
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- Rodrigo C, Campbell R, Chow J, Tong A. The effect of a 4-mg preoperative intravenous dose of ondansetron in preventing nausea and vomiting after maxillofacial surgery. Journal of Oral and Maxillofacial Surgery 1996;54(10):1171-5. - PubMed
Rothenberg 1991 {published data only}
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- Rothenberg DM, Parnass SM, Litwack K, McCarthy RJ, Newman LM. Efficacy of ephedrine in the prevention of postoperative nausea and vomiting. Anesthesia and Analgesia 1991;72(1):58-61. [PMID: ] - PubMed
Rothenberg 1998 {published data only}
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- Rothenberg DM, McCarthy RJ, Peng CC, Normoyle DA. Nausea and vomiting after dexamethasone versus droperidol following outpatient laparoscopy with a propofol-based general anesthetic. Acta Anaesthesiologica Scandinavica 1998;42(6):637-42. [PMID: 9689267] - PubMed
Rudra 2005 {published data only}
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- Rudra A, Mandal M, Rudra P, Kumar P. Comparison of droperidol and metoclopramide in the prevention of nausea - vomiting after laparoscopic cholecystectomy. Indian Journal of Anaesthesia 2005;49(2):109-12.
Ruiz 1999 {published data only}
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- Ruiz de Adana J, Tobalina Bonis R, García Galán F, Hernández Matías A, Fernández Luengas D, Ortega Deballón P, et al. Antiemetic efficacy of ondansetron in laparoscopic cholecystectomy. A randomized, double-blind, placebo-controlled study. Revista Espanola de Enfermedades Digestivas 1999;91(9):639-43. - PubMed
Rusch 1999 {published data only}
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- Rüsch D, Bernhardt J, Wulf H. Prophylaxis of nausea and vomiting after pelviscopy. Dolasetron or MCP in comparison with placebo. Anaesthetist 1999;48(10):705-12. [PMID: 10551919 ] - PubMed
Rusch 2002 {published data only}
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- Rüsch D, Palm S, Sauerwald M, Römer T, Wulf H. Prophylaxis of postoperative nausea and vomiting following gynaecological laparoscopy. Anaesthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie 2002;37(1):16-23. - PubMed
Rust 1994 {published data only}
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- Rust M, Cohen LA. Single oral dose ondansetron in the prevention of postoperative nausea and emesis. The European and US Study Groups. Anaesthesia 1994;49 Suppl:16-23. [PMID: ] - PubMed
Ryoo 2015 {published data only}
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- KCT0000581. The Effect of Palonosetron for the Prevention of Postoperative Nausea and Vomiting [The Effect of Palonosetron for the Prevention of Postoperative Nausea and Vomiting in Women Patients Using Intravenous Patient-Controlled Analgesia]. who.int/trialsearch/Trial2.aspx?TrialID=KCT0000581 (first received 14 November 2012).
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- Ryoo SH, Yoo JH, Kim MG, Lee KH, Kim SI. The effect of combination treatment using palonosetron and dexamethasone for the prevention of postoperative nausea and vomiting versus dexamethasone alone in women receiving intravenous patient-controlled analgesia. Korean Journal of Anesthesiology 2015;68(3):267-73. [DOI: 10.4097/kjae.2015.68.3.267] [PMID: ] - DOI - PMC - PubMed
Ryu 2007 {published data only}
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- Ryu WR, Lee JS, Kwon JY, Kim CH, Jang HS. The preventive effects of dexamethasone and ondansetron for postoperative nausea and vomiting after tympanomastoidectomy. Korean Journal of Anesthesiology 2007;52(5):556-60. [DOI: 10.4097/kjae.2007.52.5.556] - DOI
Ryu 2010 {published data only}
Ryu 2013 {published data only}
-
- KCT0000267. Ramosetron vs. Ramosetron Plus Dexamethasone After Laparoscopic Cholecystectomy [The Comparison of Ramosetron With Ramosetron Plus Dexamethasone for Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy]. who.int/trialsearch/Trial2.aspx?TrialID=KCT0000267 (first received 14 November 2011).
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- Ryu JH, Chang JE, Kim HR, Hwang JW, Oh AY, Do SH. Ramosetron vs. ramosetron plus dexamethasone for the prevention of postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy: prospective, randomized, and double-blind study. International Journal of Surgery 2013;11(2):183-7. [DOI: 10.1016/j.ijsu.2012.12.018] [PMID: 23313969 ] - DOI - PubMed
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- Sandhu T, Tanvatcharaphan P, Cheunjongkolkul V. Ondansetron versus metoclopramide in prophylaxis of nausea and vomiting for laparoscopic cholecystectomy: a prospective double-blind randomized study. Asian Journal of Surgery 2008;31(2):50-4. [PMID: 18490214 ] - PubMed
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- Savant K, Khandeparker RV, Berwal V, Khandeparker PV, Jain H. Comparison of ondansetron and granisetron for antiemetic prophylaxis in maxillofacial surgery patients receiving general anesthesia: a prospective, randomised, and double blind study. Journal of the Korean Association of Oral and Maxillofacial Surgeons 2016;42(2):84-9. [DOI: 10.5125/jkaoms.2016.42.2.84] [PMID: 27162748 ] - DOI - PMC - PubMed
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- JPRN-UMIN000007613. Preventing Postoperative Nausea and Vomiting: Effect of Neurokinin-1 Receptor Antagonist (Fosaprepitant). who.int/trialsearch/Trial2.aspx?TrialID=JPRN-UMIN000007613 (first received 31 March 2012).
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Veneziani 2006 {published data only}
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- Veneziani A, Dominaci M, Labardi M, Luca Noto GA, Marini F. Prevention of postoperative nausea and vomiting (PONV) in major gynecological surgery: comparison of therapeutic regimens. Acta Anaesthesiologica Italica 2006;57(2-3):185-97.
Verhasselt 1988 {published data only}
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- Verhasselt L, Troch E, Verheecke G. Dehydrobenzperidol as preoperative anti-emetic: most effective administration time. Acta Anaesthesiologica Belgica 1988;39(1):43-8. [PMID: ] - PubMed
Voigt 2011‐1 {published data only}
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- Voigt M, Frohlich CW, Waschke KF, Lenz C, Gobel U, Kerger H. Prophylaxis of postoperative nausea and vomiting in elective breast surgery. Journal of Clinical Anesthesia 2011;23(6):461-8. [PMID: ] - PubMed
Voigt 2011‐2 {published data only}
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- Voigt M, Frohlich CW, Waschke KF, Lenz C, Gobel U, Kerger H. Prophylaxis of postoperative nausea and vomiting in elective breast surgery. Journal of Clinical Anesthesia 2011;23(6):461-8. [PMID: ] - PubMed
Volpe 1994 {published data only}
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- Volpe N, Gesini A, Collini S, Grassano MT, Guzzon D, Marino MR, et al. Single dose ondansetron for prevention of postoperative nausea and vomiting. Results from the Italian multicentre ondansetron study. Drug Investigation 1994;8(2):67-72. [DOI: 10.1007/BF03257429] - DOI
Wadaskar 2008 {published data only}
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- Wadaskar A, Swarnkar N, Yadav A. Granisetron has superior control over postoperative nausea and vomiting than ondansetron in gynecological surgeries: a placebo controlled double-blind clinical study. Internet Journal of Anesthesiology 2008;20(1):8.
Wadood 2014 {published data only}
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- Wadood F, Muhammad R, Jamil M, Un Nisa W. Efficacy of ondansetron alone and ondansetron plus dexamethasone in preventing nausea and vomiting after middle ear surgery. Journal of Ayub Medical College Abbottabad 2014;26(1):80-3. [PMID: ] - PubMed
Wagley 1999 {published data only}
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- Wagley C, Hackett C, Haug RH. The effect of preoperative ondansetron on the incidence of postoperative nausea and vomiting in patients undergoing outpatient dentoalveolar surgery and general anesthesia. Journal of Oral and Maxillofacial Surgery 1999;57(10):1195-200. [PMID: ] - PubMed
Wagner 1996 {published data only}
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- Wagner BK, Berman Sl, Devitt PA, Halvorsen MB, O'Hara DA. A double-blind, placebo-controlled evaluation of intranasal metoclopramide in the prevention of postoperative nausea and vomiting. Pharmacotherapy 1996;16(6):1063-9. [PMID: ] - PubMed
Waldmann 1985 {published data only}
Wang 1995 {published data only}
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- Wang XR, Hang YN, Shun DJ, Fei BL. Ondansetron used in preventing postoperative nausea and vomiting: a randomized double-blind placebo-controlled clinical study. Chinese Journal of Anesthesiology 1995;15(10):459-61.
Wang 1999a {published data only}
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- Wang JJ, Ho ST, Liu YH, Lee SC, Liu YC, Liao YC, et al. Dexamethasone reduces nausea and vomiting after laparoscopic cholecystectomy. British Journal of Anaesthesia 1999;83(5):772-5. [PMID: ] - PubMed
Wang 1999b {published data only}
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- Wang JJ, Ho ST, Lee SC, Liu YC, Liu YH, Liao YC. The prophylactic effect of dexamethasone on postoperative nausea and vomiting in women undergoing thyroidectomy: a comparison of droperidol with saline. Anesthesia and Analgesia 1999;89(1):200-3. [PMID: ] - PubMed
Wang 2000a {published data only}
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- Wang JJ, Ho ST, Tzeng JJ, Tang CS. The effect of timing of dexamethasone administration on its efficacy as a prophylactic antiemetic for postoperative nausea and vomiting. Anesthesia and Analgesia 2000;91(1):136-9. [PMID: ] - PubMed
Wang 2000b {published data only}
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- Wang JJ, Ho ST, Liu HS, Ho CM. Prophylactic antiemetic effect of dexamethasone in women undergoing ambulatory laparoscopic surgery. British Journal of Anaesthesia 2000;84(4):459-62. [PMID: ] - PubMed
Wang 2000c {published data only}
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- Wang JJ, Ho ST, Lee SC, Liu YC, Ho CM. The use of dexamethasone for preventing postoperative nausea and vomiting in females undergoing thyroidectomy: a dose-ranging study. Anesthesia and Analgesia 2000;91(6):1404-7. [PMID: ] - PubMed
Wang 2002a {published data only}
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- Wang JJ, Wang PC, Liu YH, Chien CC. Low-dose dexamethasone reduces nausea and vomiting after tympanomastoid surgery: a comparison of tropisetron with saline. American Journal of Otolaryngology 2002;23(5):267-71. [PMID: ] - PubMed
Wang 2002b {published data only}
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- Wang JJ, Ho ST, Uen YH, Lin MT, Chen KT, Huang JC, et al. Small-dose dexamethasone reduces nausea and vomiting after laparoscopic cholecystectomy: a comparison of tropisetron with saline. Anesthesia and Analgesia 2002;95(1):229-32. [PMID: ] - PubMed
Wang 2008 {published data only}
Wang 2012 {published data only}
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- Wang PK, Tsay PJ, Huang CC, Lai HY, Lin PC, Huang SJ, et al. Comparison of dexamethasone with ondansetron or haloperidol for prevention of patient-controlled analgesia-related postoperative nausea and vomiting: a randomized clinical trial. World Journal of Surgery 2012;36(4):775-81. [DOI: 10.1007/s00268-012-1446-y] [PMID: ] - DOI - PubMed
Warrick 1999 {published data only}
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- Warrick PD, Belo SE. Treating "rebound" emesis following outpatient gynecologic laparoscopy: the efficacy of a two-dose regimen of droperidol and ondansetron. Journal of Clinical Anesthesia 1999;11(2):119-25. [PMID: ] - PubMed
Warriner 1997 {published data only}
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- Warriner CB, Knox D, Belo S, Cole C, Finegan BA, Perreault L, et al. Prophylactic oral dolasetron mesylate reduces nausea and vomiting after abdominal hysterectomy. Canadian Journal of Anaesthesia 1997;44(11):1167-73. [PMID: ] - PubMed
Watts 1996 {published data only}
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- Watts SA. A randomized double-blinded comparison of metoclopramide, ondansetron and cyclizine in day-case laparoscopy. Anaesthesia and Intensive Care 1996;24(5):546-51. [PMID: ] - PubMed
Wattwil 2003 {published data only}
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- Wattwil M, Thorn SE, Lovqvist A, Wattwil L, Gupta A, Liljegren G. Dexamethasone is as effective as ondansetron for the prevention of postoperative nausea and vomiting following breast surgery. Acta Anaesthesiologica Scandinavica 2003;47(7):823-7. [PMID: ] - PubMed
Weren 2008 {published data only}
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- Weren M, Demeere JL, Vandermeersch E. Comparing methylprednisolone to dexamethasone-treatments for PONV: a prospective, randomised, double-blind, placebo-controlled trial. Acta Anaesthesiologica Belgica 2008;59(2):118. - PubMed
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- Weren M, Demeere JL. Methylprednisolone vs. dexamethasone in the prevention of postoperative nausea and vomiting: a prospective, randomised, double-blind, placebo-controlled trial. Acta Anaesthesiologica Belgica 2008;59(1):1-5. [PMID: ] - PubMed
White 2005‐1 {published data only}
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- White PF, Song D, Abrao J, Klein KW, Navarette B. Effect of low-dose droperidol on the QT interval during and after general anesthesia: a placebo-controlled study. Anesthesiology 2005;102(6):1101-5. [PMID: ] - PubMed
White 2005‐2 {published data only}
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- White PF, Song D, Abrao J, Klein KW, Navarette B. Effect of low-dose droperidol on the QT interval during and after general anesthesia: a placebo-controlled study. Anesthesiology 2005;102(6):1101-5. [PMID: ] - PubMed
White 2006 {published data only}
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- White PF, Tang J, Hamza MA, Ogunnaike B, Lo M, Wender RH, et al. The use of oral granisetron versus intravenous ondansetron for antiemetic prophylaxis in patients undergoing laparoscopic surgery: the effect on emetic symptoms and quality of recovery. Anesthesia and Analgesia 2006;102(5):1387-93. [DOI: 10.1213/01.ane.0000208967.94601.cd] [PMID: ] - DOI - PubMed
White 2007‐1 {published data only}
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- White PF, Tang J, Song D, Coleman JE, Wender RH, Ogunnaike B, et al. Transdermal scopolamine: an alternative to ondansetron and droperidol for the prevention of postoperative and postdischarge emetic symptoms. Anesthesia and Analgesia 2007;104(1):92-6. [DOI: 10.1213/01.ane.0000250364.91567.72] [PMID: ] - DOI - PubMed
White 2007‐2 {published data only}
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- White PF, Tang J, Song D, Coleman JE, Wender RH, Ogunnaike B, et al. Transdermal scopolamine: an alternative to ondansetron and droperidol for the prevention of postoperative and postdischarge emetic symptoms. Anesthesia and Analgesia 2007;104(1):92-6. [DOI: 10.1213/01.ane.0000250364.91567.72] [PMID: ] - DOI - PubMed
Wilkinson 1989 {published data only}
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- Wilkinson AR, Frampton CM, Glover PW, Davis FM. Preoperative transdermal hyoscine for the prevention of postoperative nausea and vomiting. Anaesthesia and Intensive Care 1989;17(3):285-9. [PMID: ] - PubMed
Wilson 1996 {published data only}
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- Wilson AJ, Diemunsch P, Lindeque BG, Scheinin H, Helbo-Hansen HS, Kroeks MV, et al. Single-dose i.v. granisetron in the prevention of postoperative nausea and vomiting. British Journal of Anaesthesia 1996;76(4):515-8. [PMID: ] - PubMed
Wilson 2001 {published data only}
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- Wilson EB, Bass CS, Abrameit W, Roberson R, Smith RW. Metoclopramide versus ondansetron in prophylaxis of nausea and vomiting for laparoscopic cholecystectomy. American Journal of Surgery 2001;181(2):138-41. [PMID: ] - PubMed
Worni 2008 {published data only}
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- Worni M, Schudel HH, Seifert E, Inglin R, Hagemann M, Vorburger SA, et al. Randomized controlled trial on single dose steroid before thyroidectomy for benign disease to improve postoperative nausea, pain, and vocal function. Annals of Surgery 2008;248(6):1060-6. [DOI: 10.1097/SLA.0b013e31818c709a] [PMID: ] - DOI - PubMed
Wu 2000 {published data only}
Wu 2009 {published data only}
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- Wu JI, Lu SF, Chia YY, Yang LC, Fong WP, Tan PH. Sevoflurane with or without antiemetic prophylaxis of dexamethasone in spontaneously breathing patients undergoing outpatient anorectal surgery. Journal of Clinical Anesthesia 2009;21(7):469-73. [DOI: 10.1016/j.jclinane.2008.11.007] [PMID: ] - DOI - PubMed
Yamamoto 2003 {published data only}
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- Yamamoto S, Yamaguchi H, Sakaguchi M, Yamashita S, Satsumae T. Preoperative droperidol improved postoperative pain relief in patients undergoing rotator-cuff repair during general anesthesia using intravenous morphine. Journal of Clinical Anesthesia 2003;15(7):525-9. [PMID: ] - PubMed
Yang 1993 {published data only}
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- Yang LC, Jawan B, Chen CN, Ho RT, Chang KA, Lee JH. Comparison of P6 acupoint injection with 50% glucose in water and intravenous droperidol for prevention of vomiting after gynecological laparoscopy. Acta Anaesthesiologica Scandinavica 1993;37(2):192-4. [PMID: ] - PubMed
Yang 2015 {published data only}
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- NCT02096835. Transcutaneous Electrical Acupoint Stimulation of P6 to Prevent Postoperation Nausea and Vomiting (TEASP6PPONV) [Transcutaneous Electrical Acupoint P6 Stimulation vs. Tropisetron Both in Combination With Dexamethasone to Prevent Postoperation Nausea and Vomiting in Women]. clinicaltrials.gov/ct2/show/NCT02096835 (first received 26 March 2014).
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- Yang XY, Xiao J, Chen YH, Wang ZT, Wang HL, He DH, et al. Dexamethasone alone vs in combination with transcutaneous electrical acupoint stimulation or tropisetron for prevention of postoperative nausea and vomiting in gynaecological patients undergoing laparoscopic surgery. British Journal of Anaesthesia 2015;115(6):883-9. [DOI: 10.1093/bja/aev352] [PMID: ] - DOI - PubMed
Yang 2017 {published data only}
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- NCT02039427. The Effect of Prophylactic Ketorolac on Sore Throat After Thyroid Surgery. clinicaltrials.gov/ct2/show/NCT02039427 (first received 17 January 2014).
Yeo 2009 {published data only}
Yilmazlar 1996 {published data only}
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- Yilmazlar A, Yilmazlar T, Gurpinar E, Korun N, Kutlay O. Anti-emetic efficacy of tropisetron and metoclopramide. Journal of International Medical Research 1996;24(3):266-70. [PMID: ] - PubMed
Yilmazlar 2001 {published data only}
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- Yilmazlar A, Tokat O, Kutlay O, Yilmazlar T, Turker G. Comparison of the efficacy of 2 mg versus 5 mg tropisetron in the management of post-operative nausea and vomiting. Journal of International Medical Research 2001;29(5):385-8. [PMID: ] - PubMed
Yoon 2009 {published data only}
Yoon 2016 {published data only}
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- Yoon HJ, Jee YS, Kim YD. Comparison of the efficacy of ramosetron and palonosetron for prevention of postoperative nausea and vomiting in patients undergoing gynecologic oncology surgery. Anesthesiology and Pain Medicine 2016;11(3):264-8. [DOI: 10.17085/apm.2016.11.3.264] - DOI
Yu 2013 {published data only}
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- Yu Q, Gao L, Gu MH, Ma MM, Liu YK, Zu WQ, et al. Antiemetic effects of combined methylprednisolone and tropisetron in mastectomy. Minerva Anestesiologica 2013;79(2):130-6. [PMID: ] - PubMed
Yuksek 2003 {published data only}
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Yun 2010 {published data only}
Zarate 2000 {published data only}
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- Zarate E, Watcha MF, White PF, Klein KW, Sa Rego M, Stewart DG. A comparison of the costs and efficacy of ondansetron versus dolasetron for antiemetic prophylaxis. Anesthesia and Analgesia 2000;90(6):1352-8. [PMID: ] - PubMed
Zhang 2012 {published data only}
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- Zhang Z, Zhuang Y, Ouyang F, Zhang A, Zeng B, Gu M. Penehyclidine enhances the efficacy of tropisetron in prevention of PONV following gynecological laparoscopic surgery. Journal of Anesthesia 2012;26(6):864-9. [PMID: ] - PubMed
Zhang 2013‐1 {published data only}
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Zhang 2013‐2 {published data only}
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- Zhang D, Shen Z, You J, Zhu X, Tang QF. Effect of ondansetron in preventing postoperative nausea and vomiting under different conditions of general anesthesia: a preliminary, randomized, controlled study. Upsala Journal of Medical Sciences 2013;118(2):87-90. [DOI: 10.3109/03009734.2013.768315] [PMID: ] - DOI - PMC - PubMed
Zhou 2012 {published data only}
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- ChiCTR-TRC-09000558. Combination of Tropisetron and Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Thyroid Surgery: A Prospective Randomized Controlled Trial. who.int/trialsearch/Trial2.aspx?TrialID=ChiCTR-TRC-09000558 (first received 23 September 2009).
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- Zhou H, Xu H, Zhang J, Wang W, Wang Y, Hu Z. Combination of dexamethasone and tropisetron before thyroidectomy to alleviate postoperative nausea, vomiting, and pain: randomized controlled trial. World Journal of Surgery 2012;36(6):1217-24. [PMID: ] - PubMed
Zhu 2010 {published data only}
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- Zhu HX, Xu YJ, Meng SF, Feng H, Liu Y, Su XJ. Preventive effect of acupoint injection at neiguan (PC 6) on postoperative nausea and vomiting after laparoscopic gynecologic surgery. Zhongguo Zhen Jiu [Chinese Acupuncture & Moxibustion] 2010;30(1):72-4. [PMID: ] - PubMed
Zomers 1993 {published data only}
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- Zomers PJ, Langenberg CJ, Bruijn KM. Tropisetron for postoperative nausea and vomiting in patients after gynaecological surgery. British Journal of Anaesthesia 1993;71(5):677-80. [PMID: ] - PubMed
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References to studies excluded from this review
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Ambesh 1999 {published data only}
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Anonymous 1994 {published data only}
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Antonini 1994 {published data only}
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- Antonini M, D'Errico RR, Della Rocca G, Oliva P, Coccia C, Pastore E. Anesthesia in laparoscopic cholecystectomy: evaluation of the use of nitrous oxide. Acta Anaesthesiologica Italica 1994;45(2 Suppl):243-9.
Apfel 2002 {published data only}
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Arcioni 2002 {published data only}
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- Arcioni R, della Rocca M, Romano S, Romano R, Pietropaoli P, Gasparetto A. Ondansetron inhibits the analgesic effects of tramadol: a possible 5-HT3 spinal receptor involvement in acute pain in humans. Anesthesia and Analgesia 2002;94(6):1553-7. [PMID: ] - PubMed
Arlia 1966 {published data only}
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- Arlia R. The use of thiethylperazine in control of postoperative vomiting. Prensa Medica Argentina 1966;53(18):1035-8. [PMID: ] - PubMed
Arndt 1997 {published data only}
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- Arndt GA, Springman SR, McSweeney M. A comparison of the incidence of nausea and vomiting following ondansetron premedication in two outpatient anesthetics and patients having tubal ligations. Acta Anaesthesiologica Scandinavica 1997;41(Suppl 110):182.
Aronson 1986 {published data only}
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- Aronson JK, Sear JW. Transdermal hyoscine (scopolamine) and postoperative vomiting. Anaesthesia 1986;41(1):1-3. [PMID: ] - PubMed
Arsian 2000 {published data only}
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- Arsian G, Gureler C, Ozden A, Karamanlioglu B, Pamukcu Z. Role of tropisetron, granisetron and dexamethasone in prophylaxis of nausea and vomiting seen after gynaecological operations. European Journal of Anaesthesiology 2000;17 Suppl 19:30.
Arslan 2011a {published data only}
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- Arslan M, Demir ME. Prevention of postoperative nausea and vomiting with a small dose of propofol combined with dexamethasone 4 mg or dexamethasone 8 mg in patients undergoing middle ear surgery: a prospective, randomized, double-blind study. Bratislavske Lekarske Listy 2011;112(6):332-6. [PMID: ] - PubMed
Ascari 1999 {published data only}
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Asl 2011 {published data only}
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Atsuta 2017 {published data only}
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Badaoui 2000 {published data only}
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Bajaj 1980 {published data only}
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- Bajaj P, Somani SR, Vora YC. A clinical trial with the new antiemetic metoclopramide in the prevention of postoperative nausea and vomiting. Clinician 1980;44(7):328-33.
Bakeer 2019 {published data only}
Banerjee 2014 {published data only}
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Barden 2020 {published data only}
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Barron 1984 {published data only}
Barros‐de‐Oliveira 2002 {published data only}
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Barry 2004 {published data only}
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Barsoum 1990 {published data only}
Bartlett 2013 {published data only}
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Barton 1975 {published data only}
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Batistaki 2019 {published data only}
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- Batistaki C, Pandazi A, Kyttari A, Kaminiotis E, Kostopanagiotou G. Is there an interaction between dexamethasone and sugammadex in real clinical conditions? A randomized controlled trial in patients undergoing laparoscopic cholecystectomy. Journal of Anaesthesiology Clinical Pharmacology 2019;35(2):215-9. [DOI: ] - PMC - PubMed
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Berg 1996 {published data only}
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- Chen JJ, Frame DG, White TJ. Efficacy of ondansetron and prochlorperazine for the prevention of postoperative nausea and vomiting after total hip replacement or total knee replacement procedures: a randomized, double-blind, comparative trial. Archives of Internal Medicine 1998;158(19):2124-8. [PMID: ] - PubMed
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Cho 2016 {published data only}
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- Cho JS, Kim EJ, Lee JH, Kim SY, Kim JM, Byun JF, et al. Betahistine reduces postoperative nausea and vomiting after laparoscopic gynecological surgery. Minerva Anestesiologica 2016;82(6):649-56. [PMID: ] - PubMed
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Davidson 1979 {published data only}
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Desmillieres 1977 {published data only}
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- Ellis FR, Spence AA. Clinical trials of metoclopramide (Maxolon) as an antiemetic in anaesthesia. Anaesthesia 1970;25(3):368-71. [PMID: ] - PubMed
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Entezariasl 2013 {published data only}
Fang 2014 {published data only}
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- Fang QW, Qian XY, An, JX, Wen H, Wu JP, Cope DK, et al. Pre-induction dexamethasone does not decrease postoperative nausea and vomiting after microvascular decompression for facial spasm. Chinese Medical Journal 2014;127(14):2711-2. [DOI: 10.3760/cma.j.issn.0366-6999.20140299] [PMID: ] - DOI - PubMed
Fassolt 1977 {published data only}
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Fassoulaki 1989 {published data only}
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Fisher 1984 {published data only}
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Fitzpatrick 1987 {published data only}
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- Fitzpatrick KTJ, Dundee JW, Ghaly RG. Comparison on the anti-emetic action of manual and electro acupuncture with that of cyclizine and metoclopramide. British Journal of Anaesthesia 1987;59:936-7.
Fonseca 2001 {published data only}
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- Fonseca NM, Cardoso RC. Nausea and vomiting prevention with metoclopramide in patients submitted to uterine curettage under general anesthesia. Revista Brasileira de Anestesiologia 2001;51(2):105-11.
Foster 1996a {published data only}
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Fragen 1978 {published data only}
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- Franklyn K, Sahajanandan R, Priyadarshini K. Comparative study of the effects of intravenous palonosetron vs. ondansetron and dexamethasone for prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy: a prospective randomised control study. In: Anaesthesia. Vol. 74. 2019:61. [DOI: 10.1111/anae.14540] - DOI
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Freymond 2002 {published data only}
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Fukushima 2001 {published data only}
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Gan 1995 {published data only}
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Gan 2009a {published data only}
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- Gan TJ, Candiotti KA, Klein SM, Rodriguez Y, Nielsen KC, White WD, et al. Double-blind comparison of granisetron, promethazine, or a combination of both for the prevention of postoperative nausea and vomiting in females undergoing outpatient laparoscopies. Canadian Journal of Anaesthesia 2009;56(11):829-36. [DOI: 10.1007/s12630-009-9175-x] [PMID: ] - DOI - PubMed
Gandhi 2016 {published data only}
Gani 2010 {published data only}
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Gani 2011 {published data only}
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Ganjare 2013 {published data only}
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- Ganjare A, Kulkarni AP. Comparative electrocardiographic effects of intravenous ondansetron and granisetron in patients undergoing surgery for carcinoma breast: a prospective single-blind randomised trial. Indian Journal of Anaesthesia 2013;57(1):41-5. [DOI: 10.4103/0019-5049.108560] [PMID: ] - DOI - PMC - PubMed
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Garzozi 2006 {published data only}
Gasbjerg 2020 {published data only}
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Geng 2017 {published data only}
George 2016 {published data only}
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Ghaly 1987 {published data only}
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Gibertini 1968 {published data only}
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Glaser 1999 {published data only}
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Gougeon 1988 {published data only}
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- Gougeon SD. Bromopride for prevention of nausea and vomiting caused by epidural morphine [Bromoprida na prevençäo de náuseas e vômitos causados por morfina peridural]. Revista Brasileira de Anestesiologia 1988;38(3):193-6. [LILACS: 63151]
Grebenik 1996 {published data only}
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Guldager 1983 {published data only}
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Gupta 2006a {published data only}
Gupta 2010 {published data only}
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Gupta 2018 {published data only}
Gurha 2012 {published data only}
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- Gurha P, Kaur RD, Sanjay RR. Prophylactic intravenous palonosetron, granisetron and ondansetron in the prevention of post operative nausea and vomiting in laparoscopic surgeries. British Journal of Anaesthesia 2012;108:376. [DOI: 10.1093/bja/aer488] - DOI
Gürkan 2002 {published data only}
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Gutierrez Williams 2008 {published data only}
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Haapanen 2017 {published data only}
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Hahm 2010 {published data only}
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Hammond 1985 {published data only}
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Harper 1998 {published data only}
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Harris 1991 {published data only}
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Hartsell 2005 {published data only}
Hashemi 2015 {published data only}
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Hayashi 2002 {published data only}
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Hong 2017 {published data only}
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Huston 1996 {published data only}
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Hwang 2004 {published data only}
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Hwang 2004a {published data only}
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Ionescu 2011 {published data only}
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- Kim JY, Lee SY, Kim JS, Chae YJ, Kim JH, Baeck SH. The effect of timing of ondansetron administration on antiemetic efficacy in patients undergoing thyroidectomy. Korean Journal of Anesthesiology 2005;48(3):288-92.
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- Kim MS, Lee SY, Kim JS, Min SK, Park YD, Park HJ. The effect of ondansetron or dolasetron for the prevention of postoperative nausea and vomiting in patients with intravenous patient-controlled analgesia. Korean Journal of Anesthesiology 2007;53(5):624-9. [DOI: 10.4097/kjae.2007.53.5.624] - DOI
Kim 2007b {published data only}
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- Kim YY, Moon SY, Song DU, Lee KH, Song JW, Kwon YE. Comparison of palonosetron with ondansetron in prevention of postoperative nausea and vomiting in patients receiving intravenous patient-controlled analgesia after gynecological laparoscopic surgery. Korean Journal of Anesthesiology 2013;64(2):122-6. [DOI: 10.4097/kjae.2013.64.2.122] [PMID: ] - DOI - PMC - PubMed
Kim 2014 {published data only}
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- Kim SY, Koo BN, Shin CS, Ban M, Han K, Kim MD. The effects of single-dose dexamethasone on inflammatory response and pain after uterine artery embolisation for symptomatic fibroids or adenomyosis: a randomised controlled study. BJOG 2016;123(4):580-7. [DOI: 10.1111/1471-0528.13785] [PMID: ] - DOI - PubMed
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- Lee J, Kim M, Kang W. A randomized, double-blind, comparative study to evaluate the efficacy and safety of ramosetron injection of nausea and vomiting associated with patient-controlled analgesia in colorectal cancer patients undergoing laparoscopic colectomy. Diseases of the Colon and Rectum 2015;58(5):e283-4.
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- Lee D, Tillmanns TD, Ulm M, Mabe A, Kumar S, Elnaggar AC. Effect of transdermal scopolamine for the prevention of postoperative nausea and vomiting associated with robotic gynecologic surgery: a randomized, double-blinded, placebo-controlled trial. Journal of Gynecologic Surgery 2015;31(5):266-71. [DOI: 10.1089/gyn.2015.0047] - DOI
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Lee 2017 {published data only}
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- Malins AF, Field JM, Nesling PM, Cooper GM. Nausea and vomiting after gynaecological laparoscopy: comparison of premedication with oral ondansetron, metoclopramide and placebo. British Journal of Anaesthesia 1994;72(2):231-3. [PMID: ] - PubMed
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- Nakajima E, Iijima T, Yokomichi H, Hanawa T, Hanawa K, Matsukawa T. Epidural administration of droperidol with patient-controlled epidural analgesia reduces postoperative nausea and vomiting without prolongation of QT interval for patients undergoing gynecologic surgery, parallel randomized controlled study. Anesthesia and Analgesia 2015;1:302.
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NCT01186029 {published data only}
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- NCT01186029. Comparison of Adding EMEND to PONV/PDNV Treatment Regimen. clinicaltrials.gov/show/NCT01186029 (first received 20 August 2010).
NCT01819857 {published data only}
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- NCT01819857. Droperidol and Cardiac Repolarization. clinicaltrials.gov/show/NCT01819857 (first received 28 March 2013).
NCT02457195 {published data only}
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- NCT02457195. Granisetron Transdermal Patch for Prevention of Postoperative Nausea and Vomiting. ClinicalTrials.gov/show/NCT02457195 (first received 29 May 2015).
NCT02473042 {published data only}
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- NCT02473042. Intraoperative Acupoint Stimulation to Prevent Post-operative Nausea and Vomiting (PONV). ClinicalTrials.gov/show/NCT02473042 (first received 16 June 2015).
NCT02571075 {published data only}
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- NCT02571075. Battlefield Auricular Acupuncture During Adult Tonsillectomies and Effect of Post Op Pain and Nausea. ClinicalTrials.gov/show/NCT02571075 (first received 28 August 2019).
NCT02941913 {published data only}
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- NCT02941913. Compare Between Two Doses of Palonosetron on the Prevention of Postoperative Nausea and Vomiting in Obese Patients. https://ClinicalTrials.gov/show/NCT02941913 (first received 21 October 2016).
NCT02947672 {published data only}
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- NCT02947672. Intravenous Versus Intra-peritoneal Dexamethasone on the Incidence of Postoperative Nausea and Vomiting. ClinicalTrials.gov/show/NCT02947672 (first received 28 October 2016).
NCT03035942 {published data only}
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- NCT03035942. Quality of Recovery After Dexamethasone, Ondansetron or Placebo Intrathecal Morphine Administration. clinicaltrials.gov/show/NCT03035942 (first received 30 January 2017).
NCT03088696 {published data only}
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- NCT03088696. Evaluation of PC 6 "Neiguan" With Conventional Acupuncture to Prevent PONV After Laparoscopic Cholecystectomy. ClinicalTrials.gov/show/NCT03088696 (first received 23 March 2017).
NCT03125941 {published data only}
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- NCT03125941. High vs Low Dose Dexamethasone on Complications in the Immediate Postoperative Phase After Mastectomy. ClinicalTrials.gov/show/NCT03125941 (first received 24 April 2017).
NCT03197064 {published data only}
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- NCT03197064. Effect of Fosaprepitant on Motor Evoked and Somatosensory Evoked Potentials Under General Anesthesia. ClinicalTrials.gov/show/NCT03197064 (first received 23 June 2017).
NCT03202459 {published data only}
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- NCT03202459. Prophylaxy of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgery. ClinicalTrials.gov/show/NCT03202459;(first received 28 June 2017).
NCT03250494 {published data only}
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- NCT03250494. Duloxetine and Dexamethasone for Improving Postoperative Pain. clinicaltrials.gov/show/NCT03250494 (first received 15 August 2017).
NCT03297021 {published data only}
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- NCT03297021. Effects of Ondansetron Dose and Timing on Post-operative Nausea and Vomiting. ClinicalTrials.gov/show/NCT03297021 (first received 29 September 2017).
NCT03435003 {published data only}
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- NCT03435003. Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy. clinicaltrials.gov/show/NCT03435003 (first received 15 February 2018).
NCT03443778 {published data only}
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- NCT03443778. Dexamethasone-Bupivacaine Versus Bupivacaine for Tonsillectomy Pain. clinicaltrials.gov/show/NCT03443778 (first received 23 February 2018).
NCT03583489 {published data only}
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- NCT03583489. Study of APD421 With and Without Ondansetron. clinicaltrials.gov/show/NCT03583489 (first received 11 July 2018).
NCT03588338 {published data only}
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- NCT03588338. Paracetamol vs Metoclopramide on Postoperative Nausea and Vomiting. ClinicalTrials.gov/show/NCT03588338 (first received 17 July 2018).
NCT03603119 {published data only}
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- NCT03603119. Midazolam Versus Dexamethasone-Ondansetron in Preventing Postoperative Nausea-Vomiting for Laparoscopic Surgeries. https://ClinicalTrials.gov/show/NCT03603119 (first received 27 July 2018).
NCT03758170 {published data only}
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- NCT03758170. High-Dose Steroid for Knee Arthroplasty. ClinicalTrials.gov/show/NCT03758170 (first received 29 November 2018).
NCT03763734 {published data only}
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- NCT03763734. High-Dose Steroid for Knee Arthroplasty Patients Expected to Have Postoperative Pain. ClinicalTrials.gov/show/NCT03763734 (first received 4 December 2018).
NCT03763760 {published data only}
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- NCT03763760. High-Dose Steroid for Hip Arthroplasty Patients Expected to Have Postoperative Pain. ClinicalTrials.gov/show/NCT03763760 (first received 4 December 2018).
NCT03783182 {published data only}
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- NCT03783182. Betamethasone (Betapred®) as Premedication for Reducing Postoperative Vomiting and Pain After Tonsillectomy. clinicaltrials.gov/show/NCT03783182 (first received 20 December 2018).
NCT03933605 {published data only}
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- NCT03933605. Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy. clinicaltrials.gov/show/NCT03933605 (first received 1 May 2019).
NCT03944681 {published data only}
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- NCT03944681. Gender Influence on Torsadogenic Actions of Droperidol. ClinicalTrials.gov/show/NCT03944681 (first received 9 May 2019).
NCT04043247 {published data only}
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- NCT04043247. Transcutaneous Electrical Acupoint Stimulation for Prevention of Postoperative Nausea and Vomiting. clinicaltrials.gov/show/NCT04043247 (first received 2 August 2019).
NCT04054479 {published data only}
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- NCT04054479. Penehyclidine for PONV Prophylaxis After Strabismus Surgery. clinicaltrials.gov/show/NCT04054479 (first received 13 August 2019).
NCT04084912 {published data only}
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- NCT04084912. Effect of Preoperative Steroid in Total Knee Arthroplasty. clinicaltrials.gov/show/NCT04084912 (first received 10 September 2019).
NCT04123873 {published data only}
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- NCT04123873. Effect of Combinations of Paracetamol, Ibuprofen, and Dexamethasone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty. clinicaltrials.gov/show/NCT04123873 (first received 11 October 2019).
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- Tornetta FJ. Double-blind evaluation of haloperidol for antiemetic activity. Anesthesia and Analgesia 1972;51(6):964-7. [PMID: ] - PubMed
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Toyonaga 2016 {published data only}
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- Toyonaga S, Shinozuka N, Dobashi T, Iiyori N, Sudo T. The effectiveness of epidural droperidol for prophylaxis of postoperative nausea and vomiting: a comparative study of droperidol and adrenaline. Masui - Japanese Journal of Anesthesiology 2016;65(5):516-21. [PMID: ] - PubMed
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Usha 1996 {published data only}
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Valami 2017 {published data only}
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Vanacker 1988 {published data only}
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Wasfie 2018 {published data only}
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Weber 1998 {published data only}
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- Weber EWG, Slappendel R, Gielen MJM, Dirksen R. Intrathecal addition of morphine to bupivacaine is not the cause of postoperative nausea and vomiting. Regional Anesthesia and Pain Medicine 1998;23(1):81-6. [PMID: ] - PubMed
Weidmann 2001 {published data only}
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Whalley 1991 {published data only}
White 1999 {published data only}
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- White PF, Watcha MF. Postoperative nausea and vomiting: prophylaxis versus treatment. Anesthesia and Analgesia 1999;89(6):1337-9. [PMID: ] - PubMed
White 2001 {published data only}
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- White LA, Vanarase M, Brockbank K, Barrett RF. Patient-controlled analgesia and postoperative nausea and vomiting: efficacy of a continuous infusion of ondansetron. Anaesthesia 2001;56(4):365-9. [PMID: ] - PubMed
White 2002 {published data only}
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- White PF. Droperidol: a cost-effective antiemetic for over thirty years. Anesthesia and Analgesia 2002;95(4):789-90. [PMID: ] - PubMed
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White 2005a {published data only}
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Wig 2007 {published data only}
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- Wig J, Chandrashekharappa KN, Yaddanapudi LN, Nakra D, Mukherjee KK. Effect of prophylactic ondansetron on postoperative nausea and vomiting in patients on preoperative steroids undergoing craniotomy for supratentorial tumors. Journal of Neurosurgical Anesthesiology 2007;19(4):239-42. [DOI: 10.1097/ANA.0b013e3181557471] [PMID: ] - DOI - PubMed
Wilder Smith 1994 {published data only}
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Williams 1993 {published data only}
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- Williams OA, Clarke FL, Harris RW, Smith P, Peacock JE. Addition of droperidol to patient-controlled analgesia: effect on nausea and vomiting. Anaesthesia 1993;48(10):881-4. [PMID: ] - PubMed
Williams 1999 {published data only}
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- Williams PI, Smith M. An assessment of prochlorperazine buccal for the prevention of nausea and vomiting during intravenous patient-controlled analgesia with morphine following abdominal hysterectomy. European Journal of Anaesthesiology 1999;16(9):638-45. [PMID: ] - PubMed
Wong 2010 {published data only}
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- Wong SKH, Mui WLM, Ng EKW. The use of ondansetron (Zofran) to relieve postoperative nausea and vomiting after intragastric balloon placement: a randomized controlled trial. Surgical Endoscopy and Other Interventional Techniques 2010;1:S323.
Woodward 1993 {published data only}
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Woodward 1999 {published data only}
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Wrench 1996 {published data only}
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- Wrench IJ, Ward JE, Walder AD, Hobbs GJ. The prevention of postoperative nausea and vomiting using a combination of ondansetron and droperidol. Anaesthesia 1996;51(8):776-8. [PMID: ] - PubMed
Xu 2017 {published data only}
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- Xu B, Ma J, Huang Q, Huang ZY, Zhang SY, Pei FX. Two doses of low-dose perioperative dexamethasone improve the clinical outcome after total knee arthroplasty: a randomized controlled study. Knee Surgery Sports Traumatology Arthroscopy 2017;26(5):1549-56. [DOI: 10.1007/s00167-017-4506-x] - DOI - PubMed
Xu 2018 {published data only}
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- Xu H, Zhang S, Xie J, Lei Y, Cao G, Pei F. Multiple doses of perioperative dexamethasone further improve clinical outcomes after total knee arthroplasty: a prospective, randomized, controlled study. Journal of Arthroplasty 2018;33(11):3448-54. [DOI: ] - PubMed
Yalcyn 2004 {published data only}
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- Yalçyn S, Yalçyn B, Büyükçelik A, Hartig F, Pechlaner C, Apfel CC, Sessler DI. Prevention of postoperative nausea and vomiting. New England Journal of Medicine 2004;351(14):1458-9. - PubMed
Yang 1997 {published data only}
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- Yang HS, Lee C, Kim WT. Do metoclopramide with dexamethasone act synergistically in control of postoperative nausea and vomiting? Korean Journal of Anesthesiology 1997;33(6):1170-5.
Yang 2008 {published data only}
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- Yang SY, Choi YS, Shim JK, Park WK, Kwak YL. Comparison of ramosetron and ondansetron for preventing postoperative nausea and vomiting following spine surgery in highly susceptible patients. Korean Journal of Anesthesiology 2008;55(2):171-5. [DOI: 10.4097/kjae.2008.55.2.171] - DOI
Yang 2012 {published data only}
Yelken 2003 {published data only}
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- Yelken BB, Gulec S, Hedbe L, Ekemen S, Tanriverdi B. Comparison of ondansetron, tropisetron, granisetron and droperidol for prevention of PONV after gyneocological laparoscopy in patients receiving TIVA with remifentanyl and propofol. Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi 2003;31(4):189-94.
Yokoyama 1997 {published data only}
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- Yokoyama K, Takahashi H, Toyoshima M, Tanaka K. Epidural buprenorphine and epidural droperidol for post-operative nausea or vomiting. Masui - Japanese Journal of Anesthesiology 1997;46(6):798-802. [PMID: ] - PubMed
Yoo 2012 {published data only}
Yousef 2010 {published data only}
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- Yousef M, Ebrahim N, Ebrahim A, Hosssain B. Comparison of the effects of metoclopramide and droperidol associated with dexamethasone on post operative nausea and vomiting. Pakistan Journal of Biological Sciences 2010;13(24):1219-22. [PMID: ] - PubMed
Yu 2019 {published data only}
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- Yu Y, Fan H, Cheng Y, Sun JL. [Effect of intravenous granisetron combined and acupuncture point injection at PC6(Neiguan) with 0.9% sodium chlorideon postoperative nausea and vomiting after gynecological laparoscopy]. Chinese Medical Journal 2019;99(33):2606-10. [DOI: ] - PubMed
Zahedi 2012 {published data only}
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Zainuddin 2016 {published data only}
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- Zainuddin K, Lan Shi L, Izaham A, Chian Yong L, Teo R, Li Ling T, et al. Comparison of prokinetic effects of metoclopramide and octreotide in reducing gastric volume. Anesthesia and Analgesia 2016;123(3 Suppl 2):529.
Zajac 1996 {published data only}
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- Zajac K. Dexamethasone enhances antiemetic activity of droperidol in treatment of postoperative nausea and vomiting. British Journal of Anaesthesia 1996;76 Suppl 2:81.
Zajac 1997 {published data only}
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- Zajac K, Zajac M. Ondansetron can be highly effective in treatment of postoperative nausea and vomiting (PONV). Acta Anaesthesiologica Scandinavica 1997;41(Suppl 111):330.
Zajac 1998 {published data only}
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- Zajac K, Zajac M, Ciacma A. Multifactorial treatment including ondansetron eliminates postoperative nausea and vomiting. British Journal of Anaesthesia 1998;80 Suppl 1:8.
Zajac 2000 {published data only}
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- Zajac K, Zajac M, Ciacma A. Total elimination of postoperative nausea and vomiting (PONV) with ondansetron in a high-risk group of patients. European Journal of Anaesthesiology 2000;17 Suppl 19:4.
Zghidi 2011 {published data only}
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- Zghidi SM, Jaoua H, Ghariani S, Saada S, Laabidi S, Khemiri K, et al. Effectiveness of dexamethasone in postoperative analgesia after laparoscopic cholecystectomy. Regional Anesthesia and Pain Medicine 2011;2:E278-9.
Zheng 2016 {published data only}
References to studies awaiting assessment
Abdel Halim 2009 {published data only}
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- Abdel-Halim JM, ElAwady GA, ElShaikh SM, Azer MS. Gabapentin and dexamethasone as adjuvants for intraoperative and postoperative pain management. Egyptian Journal of Anaesthesia 2009;25(4):357-64.
Abusalem 2011 {published data only}
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- Abusalem OT, Aljahmi M. Single dose dexamethasone injection for the prevention of nausea and vomiting in post laparoscopic cholecystectomy patients. Rawal Medical Journal 2011;36(4):291-3.
ACTRN12615000540516 {published data only}
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- ACTRN12615000540516. Efficacy of Dexamethasone in Reducing Pain, Nausea and Vomiting, Improving Mobilisation and Reducing Hospital Stay in Hip and Knee Arthroplasty: A Double Blind Controlled Trial. who.int/trialsearch/Trial2.aspx?TrialID=ACTRN12615000540516 (first received 27 May 2015).
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Almustafa 2020 {published data only}
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- Almustafa M, Obeidat F, Mismar A, Rashdan M, Jabaiti K, Alryalat SA, et al. Role of preoperative dexamethasone nebulization in reducing bougie complications encountered after sleeve gastrectomy: a prospective double-blind control interventional study. Obesity Surgery 2020;30(2):501-6. [DOI: ] - PubMed
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- Aziz N, Naz U, Ilyas M. A comparative study between metoclopramide and dexamethasone for prevention of post operative nausea and vomiting in laparoscopic cholecystectomy. Journal of Medical Sciences 2011;19(3):129-32.
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- Bilgen S, Kızılcık N, Haliloğlu M, Yıldırım G, Kaspar EÇ, Köner Ö. Effect of the dexamethasone-ondansetron combination versus dexamethasone-aprepitant combination to prevent postoperative nausea and vomiting. Turkish Journal of Anaesthesiology and Reanimation 2018;46(5):373-80. [PMID: ] - PMC - PubMed
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Biswas 2003a {published data only}
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- Biswas BN, Rudra A, Mandal SK. Comparison of ondansetron, dexamethasone, ondansetron plus dexamethasone and placebo in the prevention of nausea and vomiting after laparoscopic tubal ligation. Journal of the Indian Medical Association 2003;101(11):638-42. [PMID: ] - PubMed
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Campbell 1990 {published data only}
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- Campbell LC, Weis FR. Comparison of three techniques on time to awakening, time to orientation and incidence of nausea and vomiting using alfentanil in balanced anesthesia in an outpatient surgical setting. AANA Journal 1990;58(3):241-7. [PMID: ] - PubMed
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Ceyhan 2004 {published data only}
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- Ceyhan A, Misirlioglu F, Guzey NA, Ozen M, Baltaci B. The effectiveness of Reliefband and metoclopramide on morphine related nausea-vomiting in intravenous patient controlled analgesia. Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi 2004;32(3):180-6.
Champion 2018 {published data only}
Chan 1983 {published data only}
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- Chan SC, Lo JR, Wong KC. Vomiting after anaesthesia for termination of pregnancy in Chinese. Singapore Medical Journal 1983;24(6):360-2. [PMID: ] - PubMed
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- Charton A, Greib N, Ruimy A, Faitot V, Noudem Y, Joshi GP, et al. Incidence of akathisia after postoperative nausea and vomiting prophylaxis with droperidol and ondansetron in outpatient surgery: a multicentre controlled randomised trial. European Journal of Anaesthesiology 2018;35(12):966-71. - PubMed
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- NCT01942343. Akathisia in Post Operative Outpatients Surgery [Etude de l'Effet du dropéridol et de l'Ondansetron Sur l'Incidence de l'Akathisie Post opératoire en Chirurgie Ambulatoire]. clinicaltrials.gov/ct2/show/NCT01942343 (first received 13 September 2013).
Chatterjee 2017 {published data only}
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- Chatterjee A, Sahu S, Paul M, Singh T, Singh S, Mishra P. Comparison of efficacy of palonosetron-dexamethasone combination with palonosetron or dexamethasone alone for prophylaxis against post-operative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Indian Journal of Anaesthesia 2017;61(12):978-84. [DOI: ] - PMC - PubMed
Chen 2002 {published data only}
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- Chen LJ, Xu L, Yang XC. Observation on curative effect of antinausea and anti vomiting of ondansetron and droperidol in gynecology operation. Modern Medicine and Health 2002;18(3):177-8.
ChiCTR‐TRC‐09000671 {published data only}
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- ChiCTR-TRC-09000671. Single Dose Aprepitant to Prevent Postoperative Nausea and Vomiting. who.int/trialsearch/Trial2.aspx?TrialID=ChiCTR-TRC-09000671 (first received 16 November 2005).
ChiCTR‐TRC‐09000672 {published data only}
-
- ChiCTR-TRC-09000672. Second Generation Antihistamine to Prevent Postoperative Nausea and Vomiting. who.int/trialsearch/Trial2.aspx?TrialID=ChiCTR-TRC-09000672 (first received 16 November 2005).
ChiCTR‐TRC‐09000739 {published data only}
-
- ChiCTR-TRC-09000739. Combination of Aprepitant and Dexamethasone to Prevent Postoperative Nausea and Vomiting. who.int/trialsearch/Trial2.aspx?TrialID=ChiCTR-TRC-09000739 (first received 27 November 2009).
Cho 2019 {published data only}
Cooke 1979 {published data only}
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- Cooke RD, Comyn DJ, Ball RW. Prevention of postoperative nausea and vomiting by domperidone: a double-blind randomized study using domperidone, metoclopramide and a placebo. South African Medical Journal 1979;56(21):827-9. [PMID: ] - PubMed
Cosar 1997 {published data only}
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- Cosar A, Dagli G, Kurt E, Acar HV, Suer AH. Does tropisetron prevent the postoperative nausea and vomiting? Turk Anesteziyoloji ve Reanimasyon 1997;25(7):309-12.
CTRI/2012/05/002668 {published data only}
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- CTRI/2012/05/002668. To Study the Effect of Metoclopramide and Dexamethasone Drugs in Reducing Vomiting in Patients Undergoing Laparoscopic Cholecystectomy. who.int/trialsearch/Trial2.aspx?TrialID=CTRI/2012/05/002668 (first received 18 May 2012).
CTRI/2013/03/003507 {published data only}
-
- CTRI/2013/03/003507. Ondansetron, Orally Disintegrating Film Versus Intravenous Injection for Prevention of Post Operative Nausea Vomiting in Middle Ear and Nasal Surgeries - A Randomized, Placebo Controlled Trial [Ondansetron (Drug Preventing Vomiting) Strip Versus Intravenous Injection for Ear and Nose Surgeries After Operation]. ctri.nic.in/Clinicaltrials/pdf_generate.php?trialid=6075 (first received 21 March 2013).
CTRI/2013/04/003570 {published data only}
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- CTRI/2013/04/003570. Comparatative Study on the Effectiveness of Granisetron (Antiemetic) and Metoclopramide (Antiemetic) for Reducing Propofol (Intravenous Inducing Agent) Injection Pain. who.int/trialsearch/Trial2.aspx?TrialID=CTRI/2013/04/003570 (first received 22 April 2013).
CTRI/2013/05/003630 {published data only}
-
- CTRI/2013/05/003630. A Clinical Trial Comparing Two Drugs Palonosetron and Dexamethasone and Their Combination for Prevention of Post Operative Nausea and Vomiting of Patient Undergoing Laparoscopic Cholecystectomy Operation. who.int/trialsearch/Trial2.aspx?TrialID=CTRI/2013/05/003630 (first received 10 May 2013).
CTRI/2014/11/005214 {published data only}
-
- CTRI/2014/11/005214. Comparison of Different Antiemetics for Prevention of Vomiting After Laparoscopic Surgery [Comparison of Palonosetron 0.075 mg, Palonosetron 0.15 mg and Palonosetron-Dexamethasone Combination for Prevention of Postoperative Nausea and Vomiting After Laparoscopic Procedure]. who.int/trialsearch/Trial2.aspx?TrialID=CTRI/2014/11/005214 (first received 20 November 2014).
CTRI/2014/12/005333 {published data only}
-
- CTRI/2014/12/005333. Comparison Between Aprepitant and Dexamethasone for Preventing Postoperative Nausea and Vomiting in Breast Cancer Patients. who.int/trialsearch/Trial2.aspx?TrialID=CTRI/2014/12/005333 (first received 30 December 2014).
CTRI/2015/03/005616 {published data only}
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- CTRI/2015/03/005616. Comparison of Two Drugs for Prevention of Nausea and Vomiting in Patients Undergoing Surgery for Brain Tumors. who.int/trialsearch/Trial2.aspx?TrialID=CTRI/2015/03/005616 (first received 10 March 2015).
CTRI/2015/09/006223 {published data only}
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- CTRI/2015/09/006223. Comparison of Palanosetron and Dexamethasone With Ondansetron and Dexamethasone for Prevention of Nausea and Vomiting After Operation in Cancer Patients Receiving Opioid Based Pain Relief Medicine. who.int/trialsearch/Trial2.aspx?TrialID=CTRI/2015/09/006223 (first received 29 September 2015).
CTRI/2016/07/007108 {published data only}
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- CTRI/2016/07/007108. Comparison for Intravenous Palonosetron, Dexamethasone and Their Combination as Antiemetic Therapy in Laparoscopic Surgeries. who.int/trialsearch/Trial2.aspx?TrialID=CTRI/2016/07/007108 (first received 20 July 2016).
CTRI/2016/08/007195 {published data only}
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- CTRI/2016/08/007195. Comparison of Two Drug Groups to Prevent Nausea and Vomiting in Obese Patients Undergoing Weight Reduction Surgery. who.int/trialsearch/Trial2.aspx?TrialID=CTRI/2016/08/007195 (first received 17 August 2016).
CTRI/2017/03/007998 {published data only}
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- CTRI/2017/03/007998. Prevention of Nausea and Vomiting in Middle Ear Surgery by Comparison of Palonosetron & Dexamethasone and Ondansetron & Dexamethasone Combination. who.int/trialsearch/Trial2.aspx?TrialID=CTRI/2017/03/007998 (first received 03 March 2017).
CTRI/2017/06/008769 {published data only}
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- CTRI/2017/08/009295. Comparison of Medicines to Prevent Nausea and Vomiting After Surgery to Remove Gall Bladder Through a Very Small Incision With Gas Insufflation of Abdomen. who.int/trialsearch/Trial2.aspx?TrialID=CTRI/2017/08/009295 (first received 08 August 2017).
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- EUCTR2004-004280-30-SE. Injestion of the Steroid Betamethasone During Operation for Inguinal Hernia Repair for Purpose to Optimize Treatment of Postoperative Pain, Reduction of Postoperative Discomfort Like Nausea and Possibly Prevention of Long Lasting Pain - Betamethasone for Hernia Operation. who.int/trialsearch/Trial2.aspx?TrialID=EUCTR2004-004280-30-SE (first received 04 November 2004).
EUCTR2005‐005928‐13‐IS {published data only}
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- EUCTR2005-005928-13-IS. Prospective Randomized Double Blind Trial on the Use of Scopoderm Patch for Control of Post-operative Nausea and Vomiting in Patients Undergoing Gynecologic Laparoscopic Procedures. who.int/trialsearch/Trial2.aspx?TrialID=EUCTR2005-005928-13-IS (first received 18 January 2006).
EUCTR2006‐001761‐42‐LT {published data only}
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- EUCTR2006-001761-42-LT. A Randomized, Double-Blind, Active Comparator-Controlled, Parallel-Group Study Conducted Under In-House Blinding Conditions, to Examine the Safety, Tolerability, and Efficacy of Aprepitant for the Prevention of Postoperative Nausea and Vomiting (PONV). who.int/trialsearch/Trial2.aspx?TrialID=EUCTR2006-001761-42-LT (first received 24 April 2006).
EUCTR2010‐019899‐77‐DK {published data only}
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- EUCTR2010-019899-77-DK. Can Preoperative Dexamethasone Optimise Surgical Outcomes After Laparoscopic Inguinal Hernia Repair. who.int/trialsearch/Trial2.aspx?TrialID=EUCTR2010-019899-77-DK (first received 18 May 2010).
EUCTR2015‐003956‐32‐SE {published data only}
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- EUCTR2015-003956-32-SE. Can the Drug Palonosetron Reduce the Risk for Postdischarge Nausea and Vomiting the Days After Ambulatory Surgery? who.int/trialsearch/Trial2.aspx?TrialID=EUCTR2015-003956-32-SE (first received 14 January 2016).
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IRCT138902253931N1 {published data only}
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- IRCT138902253931N1. Effects of Dexamethasone on Nausea and Vomiting After Cholecystectomy. who.int/trialsearch/Trial2.aspx?TrialID=IRCT138902253931N1 (first received 14 June 2010).
IRCT201008254505N1 {published data only}
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- IRCT201008254505N1. Comparison of Dexamethasone and Methoclopramide on Nausea and Vomiting. who.int/trialsearch/Trial2.aspx?TrialID=IRCT201008254505N1 (first received 11 September 2010).
IRCT201009084715N1 {published data only}
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- IRCT201009084715N1. Comparison of the Effectiveness of Ondansetron and Metoclopramide Combined With Dexamethasone on the Prevention of Nausea and Vomiting After Laparoscopic Cholecystectomy. who.int/trialsearch/Trial2.aspx?TrialID=IRCT201009084715N1 (first received 14 October 2010).
IRCT201012133181N3 {published data only}
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- IRCT201012133181N3. Effect of Dexamethasone on Nausea and Vomiting. who.int/trialsearch/Trial2.aspx?TrialID=IRCT201012133181N3 (first received 28 February 2012).
IRCT201105056392N1 {published data only}
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- IRCT201105056392N1. Effect of Ondansetron and Dexamethasone on Post Operative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy. who.int/trialsearch/Trial2.aspx?TrialID=IRCT201105056392N1 (first received 11 June 2011).
IRCT201108067093N2 {published data only}
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- IRCT201108067093N2. Comparison of Various Combinations of Ondansetron, Dexamethasone and Metoclopramide for Prevention of Post Operative Nausea and Vomiting. who.int/trialsearch/Trial2.aspx?TrialID=IRCT201108067093N2 (first received 26 September 2012).
IRCT201108147324N1 {published data only}
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- IRCT201108147324N1. Prophylactic Effects of Ondansetron. who.int/trialsearch/Trial2.aspx?TrialID=IRCT201108147324N1 (first received 18 July 2012).
IRCT201112088329N1 {published data only}
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- IRCT201112088329N1. Effect of Dexamethasone on Prophylaxis of Nausea and Vomiting After Laparoscopic Cholecystectomy. who.int/trialsearch/Trial2.aspx?TrialID=IRCT201112088329N1 (first received 06 January 2012).
IRCT201207223915N7 {published data only}
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- IRCT201207223915N7. Comparing Different Drugs in Prevention of Post-tympanoplasty Nausea and Vomiting. who.int/trialsearch/Trial2.aspx?TrialID=IRCT201207223915N7 (first received 25 July 2012).
IRCT201208075225N2 {published data only}
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- IRCT201208075225N2. Comparison of Antiemetic Effects of Gabapentin and Dexamethasone in Patients Who Are Candidates of Middle Ear Surgery in the year 2012 in Valiasr Hospital. who.int/trialsearch/Trial2.aspx?TrialID=IRCT201208075225N2 (first received 20 August 2012).
IRCT2014012511700N3 {published data only}
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- IRCT2014012511700N3. Effect of Combined Dexamethasone-Ondansetron Versus Dexamethasone and Ondansetron Alone for the Prevention of Nausea and Vomiting After Outpatient Gynecological Diagnostic Laparoscopy. who.int/trialsearch/Trial2.aspx?TrialID=IRCT2014012511700N3 (first received 05 February 2014).
IRCT2015042715281N3 {published data only}
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- IRCT2015042715281N3. Comparison of Prophylactic Antiemetic Effect of Three Medicines in Surgical Procedures. who.int/trialsearch/Trial2.aspx?TrialID=IRCT2015042715281N3 (first received 23 November 2015).
IRCT2016030126853N1 {published data only}
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- IRCT2016030126853N1. Evaluating the Effects of Using Dexamethasone and Chlorpheniramine in the Prevention of Postoperative Nausea and Pain in Patients Undergoing Laparoscopic Gallbladder Surgery. who.int/trialsearch/Trial2.aspx?TrialID=IRCT2016030126853N1 (first received 01 May 2016).
IRCT2016120831302N1 {published data only}
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- IRCT2016120831302N1. The Effect of Oral Aprepitant and Ondansetron Injection on Postoperative Nausea and Vomiting. who.int/trialsearch/Trial2.aspx?TrialID=IRCT2016120831302N1 (first received 17 May 2017).
IRCT2016122019359N8 {published data only}
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- IRCT2016122019359N8. Compare Adequate Intraoperative Fluid Therapy With Dexamethasone on the Incidence and Severity of Nausea and Vomiting After General. who.int/trialsearch/Trial2.aspx?TrialID=IRCT2016122019359N8 (first received 27 December 2016).
IRCT2017010923559N7 {published data only}
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- IRCT2017010923559N7. The Comparison of Two Combinations of Dexamethasone and Ondansetron With Dexamethasone and Plasil on Nausea, Vomiting and Chills. who.int/trialsearch/Trial2.aspx?TrialID=IRCT2017010923559N7 (first received 20 March 2017).
IRCT2017011920588N5 {published data only}
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- IRCT2017011920588N5. Nausea and Vomiting After Strabismus Surgery. who.int/trialsearch/Trial2.aspx?TrialID=IRCT2017011920588N5 (first received 30 June 2017).
IRCT2017020725732N13 {published data only}
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- IRCT2017020725732N13. Comparison of the Effect of Ondansetron, Dexamethasone and Their Combination in Reducing Nausea and Vomiting Following Laparoscopic Cholecystectomy in Patients Referred to Semnan Kosar Hospital. who.int/trialsearch/Trial2.aspx?TrialID=IRCT2017020725732N13 (first received 01 May 2017).
IRCT2017031433069N1 {published data only}
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- IRCT2017031433069N1. Effect of Magnesium Sulfate, Ondansetron, Metoclopramide and Low Dose of Propofol on Pain Reduction Due to Propofol Injection in Gynecologic Surgeries. who.int/trialsearch/Trial2.aspx?TrialID=IRCT2017031433069N1 (first received 29 September 2017).
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- IRCT201110194093N2. The Effect of Ondansetron and Dexamethasone on Reduction of Postoperative Nausea and Vomiting (PONV) in Laparoscopic Cholecystectomy. who.int/trialsearch/Trial2.aspx?TrialID=IRCT201110194093N2 (first received 15 November 2011).
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- ISRCTN18556628. A Study to Establish the Efficacy of Dexamethasone Used in Combination With Cyclizine in the Prevention of Post Operative Nausea and Vomiting. who.int/trialsearch/Trial2.aspx?TrialID=ISRCTN18556628 (first received 30 September 2005).
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- ISRCTN21871435. Haloperidol as an Antiemetic Following Abdominal Hysterectomy - A Comparison With Zofran®. who.int/trialsearch/Trial2.aspx?TrialID=ISRCTN21871435 (first received 12 September 2003).
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- JPRN-UMIN000012365. Preventing Postoperative Nausea and Vomiting, Effect of Dexamethasone. who.int/trialsearch/Trial2.aspx?TrialID=JPRN-UMIN000012365 (first received 01 December 2013).
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- JPRN-UMIN000018532. Fosaprepitant Versus Ondansetron for Prevention of Postoperative Nausea and Vomiting in Oral and Maxillofacial Surgery. who.int/trialsearch/Trial2.aspx?TrialID=JPRN-UMIN000018532 (first received 10 October 2015).
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- Kamali A, Ahmadi L, Shokrpour M, Pazuki S. Investigation of ondansetron, haloperidol, and dexmedetomidine efficacy for prevention of postoperative nausea and vomiting In patients with abdominal hysterectomy. Open Access Macedonian Journal of Medical Sciences 2018;6(9):1659-63. [DOI: ] - PMC - PubMed
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KCT0000487 {published data only}
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- KCT0000487. Effect of Palonosetron on Intravenous Patient-Controlled Analgesia Related Nausea and Vomiting After Abdominal Surgery. who.int/trialsearch/Trial2.aspx?TrialID=KCT0000487 (first received 19 July 2012).
KCT0000809 {published data only}
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- KCT0000809. A Comparison Study of Ondansetron and Palonosetron for the Prevention of Postoperative Nausea and Vomiting. who.int/trialsearch/Trial2.aspx?TrialID=KCT0000809 (first received 27 July 2013).
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- KCT0000899. The Comparative Study for Prevention of Postoperative Nausea and Vomiting in High Risk Patient Undergoing Thyroidectomy. who.int/trialsearch/Trial2.aspx?TrialID=KCT0000899 (first received 24 October 2013).
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- KCT0001740. Comparison of Pain and Nausea, Vomiting Control Effect of Steroid in Total Knee Arthroplasty. who.int/trialsearch/Trial2.aspx?TrialID=KCT0001740 (first received 23 December 2015).
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- KCT0002433. The Effect of Combination of Palonosetron and Aprepitant for the Prevention of Postoperative Nausea and Vomiting in Women Patients Using Intravenous Patient-Controlled Analgesia: Combination of Palonosetron and Aprepitant vs Palonosetron Alone. who.int/trialsearch/Trial2.aspx?TrialID=KCT0002433 (first received 28 August 2017).
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- NCT00674713. Effect of Acupuncture on Postoperative Nausea and Vomiting. clinicaltrials.gov/ct2/show/NCT00674713 (first received 08 May 2008).
NCT00702442 {published data only}
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- NCT00702442. Role of Droperidol in Postoperative Vomiting. clinicaltrials.gov/ct2/show/NCT00702442 (first received 20 June 2008).
NCT00738621 {published data only}
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- NCT00738621. Combination Antiemetic Regimen for Prevention of PONV in Breast Surgery Patients [A Comparison of Combination Antiemetic Regimen for Prevention of PONV in Breast Surgery Patients]. clinicaltrials.gov/ct2/show/NCT00738621 (first received 20 August 2008).
NCT00835965 {published data only}
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- NCT00835965. Oral Aprepitant and Lower Dose Dexamethasone Versus Aprepitant Alone for Preventing Postoperative Nausea and Vomiting (PONV) After Elective Laparoscopic Surgeries. clinicaltrials.gov/ct2/show/NCT00835965 (first received 04 February 2009).
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- NCT01013012. Efficacy of Dexamethasone Added to Ramosetron for Preventing Postoperative Nausea and Vomiting in Highly Susceptible Patients Following Spine Surgery. clinicaltrials.gov/ct2/show/NCT01013012 (first received 13 November 2009). - PMC - PubMed
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- NCT01022528. Analgesic Effect of Preoperative Dexamethasone in Gynecological Laparotomies - A Dose-ranging Study. clinicaltrials.gov/ct2/show/NCT01022528 (first received 01 December 2009).
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- NCT01149616. Effects of Perioperative Intravenous Dexamethasone on Pain in Outpatient Knee Surgery. clinicaltrials.gov/ct2/show/NCT01149616 (first received 23 June 2010).
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- NCT01159548. Efficacy of Low Dose Promethazine for Postoperative Nausea and Vomiting. clinicaltrials.gov/ct2/show/NCT01159548 (first received 27 July 2011).
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- NCT01402622. The Effect of Total Intravenous Anesthesia With Propofol on Postoperative Nausea and Vomiting in Patients Undergoing Robot-assisted Laparoscopic Radical Prostatectomy. clinicaltrials.gov/ct2/show/NCT01402622 (first received 26 July 2011).
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- NCT01427127. Effect of Ramosetron on Bowel Motility After Colorectal Resection. clinicaltrials.gov/ct2/show/NCT01427127 (first received 01 September 2011).
NCT01524731 {published data only}
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- NCT01524731. The Effect of Prophylactic Antiemetic Dexamethasone on Plasma Cortisol Levels. clinicaltrials.gov/ct2/show/NCT01524731 (first received 02 February 2012).
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- NCT01612702. Efficacy and Safety of Single, Low-dose Dexamethasone in Patients After Total Knee Arthroplasty [The Use of a Single, Low-dose Dexamethasone in Total Knee Arthroplasty]. clinicaltrials.gov/ct2/show/NCT01612702 (first received 6 June 2012).
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- NCT01637545. Evaluation of Safety and Efficacy of Nasea(R)/Ramosetron Inj. in Patients Undergoing Facial Bone Fracture Operations. clinicaltrials.gov/ct2/show/NCT01637545 (first received 11 July 2012).
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- NCT01679093. Antagonism Research Between Antiemetics Agents and Acetaminophen in Thyroidectomy's Post-operative Analgesia (ANPATHY). clinicaltrials.gov/ct2/show/NCT01679093 (first received 05 September 2012).
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- NCT01811251. Co-analgesic Effects of Dexamethasone and Pregabalin After Lumbar Slipped Disc Surgery (DEXA-PG-HD). clinicaltrials.gov/ct2/show/NCT01811251 (first received 14 March 2013).
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- NCT02011659. Long Term Prevention of Nausea and Vomiting in Gynecologic Laparoscopy (PONV). clinicaltrials.gov/ct2/show/NCT02011659 (first received 13 December 2013).
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- NCT02234466. Preoperative Oral Dexamethasone to Improve Recovery After Surgery. clinicaltrials.gov/ct2/show/NCT02234466 (first received 09 September 2014).
NCT02304250 {published data only}
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- NCT02304250. Dexamethasone and Wound Healing After Thyroid Surgery. clinicaltrials.gov/ct2/show/NCT02304250 (first received 01 December 2014).
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- NCT02416115. Anti Emetic Efficacy of Combination of Ramosetron and Premixture of Naloxone With Patient-controlled Analgesia. clinicaltrials.gov/ct2/show/NCT02416115 (first received 14 April 2015).
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- NCT02431286. Palonosetron Associated to Aprepitant in Prophylaxis of PONV (PONV). clinicaltrials.gov/ct2/show/NCT02431286 (first received 01 May 2015).
NCT02510157 {published data only}
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- NCT02510157. Effect of Dexamethasone on the Action of Sugammadex. clinicaltrials.gov/ct2/show/NCT02510157 (first received 29 July 2015).
NCT02525848 {published data only}
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- NCT02525848. Aprepitant Versus Gabapentin Prophylaxis for Postoperative Nausea and Vomiting in Laparoscopic Gynecological Surgeries (PONV). clinicaltrials.gov/ct2/show/NCT02525848 (first received 24 March 2016).
NCT02541019 {published data only}
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- NCT02541019. Prophylactic Antiemetic Efficacy of Palonosetron Versus Ondansetron for the Prophylaxis of Postoperative Nausea and Vomiting (PONV) in Women Over 60 Years Undergoing Laparoscopic Cholecystectomy. clinicaltrials.gov/ct2/show/NCT02541019 (first received 04 September 2015).
NCT02594241 {published data only}
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- NCT02594241. PreOperative Steroid in Abdominal Wall Reconstruction: A Double-blinded Randomized Clinical Trial (POSAR). clinicaltrials.gov/ct2/show/NCT02594241 (first received 03 November 2015).
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- NCT02711449. Preoperative Methylprednisolone to Patients Suspected of Appendicitis Undergoing Laparoscopy. clinicaltrials.gov/ct2/show/NCT02711449 (first received 17 March 2016).
NCT02744495 {published data only}
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- NCT02744495. Prophylaxis of Postoperative Nausea and Vomiting After Cardiac Surgery (PONVACS). clinicaltrials.gov/ct2/show/NCT02744495 (first received 20 April 2016).
NCT02744508 {published data only}
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- NCT02744508. Comparison of Palonosetron Versus Combination of Palonosetron and Dexamethasone for Preventing Postoperative Vomiting in Patients Receiving Fentanyl by Patient-controlled Analgesia After Minor Orthopedic Surgery. clinicaltrials.gov/ct2/show/NCT02744508 (first received 20 April 2016).
NCT02755116 {published data only}
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- NCT02755116. Olanzapine for Nausea After Surgery. ClinicalTrials.gov/show/NCT02755116 (first received 28 April 2016).
NCT02767882 {published data only}
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- NCT02767882. Dexamethasone in Pain Control After Total Knee Replacement. clinicaltrials.gov/ct2/show/NCT02767882 (first received 10 May 2016).
NCT02803788 {published data only}
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- NCT02803788. Post-operative Nausea Vomiting in Laparoscopic Cholecystectomy (PONV). clinicaltrials.gov/ct2/show/NCT02803788 (first received 17 June 2016).
NCT02809378 {published data only}
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- NCT02809378. The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of PONV [The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of Postoperative Nausea and Vomiting in the Women Patients Undergoing Thyroidectomy]. clinicaltrials.gov/ct2/show/NCT02809378 (first received 22 June 2016).
NCT02849483 {published data only}
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- NCT02849483. Effect of Ramosetron on Postoperative Restoration of Bowel Motility After Gynecological Laparoscopic Surgery. clinicaltrials.gov/show/NCT02849483 (first received 27 July 2016).
NCT02884180 {published data only}
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- NCT02884180. DEXRAR: DEXamethasone in Revision ARthroplasty (DEXRAR). clinicaltrials.gov/ct2/show/NCT02884180 (first received 30 August 2016).
NCT02966041 {published data only}
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- NCT02966041. Prophylactic Ondansetron in Post-op Cardiac Surgery Patients to Prevent Post-operative Nausea and Vomiting. clinicaltrials.gov/ct2/show/NCT02966041 (first received 17 November 2016).
NCT02968082 {published data only}
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- NCT02968082. The Effects of Preoperative Scopolamine Patch Application on the Postoperative Nausea and Vomiting in MVD Surgery. clinicaltrials.gov/ct2/show/NCT02968082 (first received 18 November 2016).
NCT03034733 {published data only}
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- NCT03034733. The Effect of Dexamethasone on Pain After Total Knee Replacement Surgery. clinicaltrials.gov/ct2/show/NCT03034733 (first received 27 January 2017).
NCT03094442 {published data only}
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- NCT03094442. Does Dexamethasone Administration Improve Recovery In Patients Undergoing Minimally Invasive Sacrocolpopexy? clinicaltrials.gov/ct2/show/NCT03094442 (first received 29 March 2017).
NCT03141645 {published data only}
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- NCT03141645. Comparison of IV Fluid Loading and Ondansetron in Reduction of PONV After LC. clinicaltrials.gov/ct2/show/NCT03141645 (first received 15 September 2017).
NCT03218553 {published data only}
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- NCT03218553. Effects of Perioperative Administration of Dexamethasone on Postoperative Complications and Mortality After Non-cardiac Major Surgery (PACMAN). clinicaltrials.gov/ct2/show/NCT03218553 (first received 14 July 2017).
NCT03278522 {published data only}
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- NCT03278522. Ramosetron Pre-treatment for PONV and QT Prolongation. clinicaltrials.gov/ct2/show/NCT03278522 (first received 11 September 2017).
NCT03338400 {published data only}
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- NCT03338400. Dexamethasone Administration to Improve Patient Recovery In Ambulatory Vaginal Prolapse Surgery: Is There a Role? clinicaltrials.gov/show/NCT03338400 (first received 9 November 2017).
NCT03403517 {published data only}
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- NCT03403517. Preoperative High Dose Steroids for Liver Resection - Effect on Complications in the Immediate Postoperative Period. clinicaltrials.gov/show/NCT03403517 (first received 18 January 2018).
NCT03409835 {published data only}
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- NCT03409835. Effect of Ramosetron on Post-discharge Nausea and Vomiting. clinicaltrials.gov/show/NCT03409835 (first received 24 January 2018).
NCT03459248 {published data only}
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- NCT03459248. Metoclopramide-Ondansetron vs. Metoclopramide Therapy for Treatment of Nausea and Vomiting Post Laparoscopic Surgery. clinicaltrials.gov/show/NCT03459248 (first received 8 March 2018).
NCT03586817 {published data only}
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- NCT03586817. Palonosteron x Fosaprepitant in PONV. clinicaltrials.gov/show/NCT03586817 (first received 16 July 2018).
NCT03631004 {published data only}
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- NCT03631004. Pre-operative Olanzapine as Prophylactic Antiemetic in Oncologic Patients. clinicaltrials.gov/show/NCT03631004 (first received 15 August 2018).
NCT03685032 {published data only}
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- NCT03685032. Effects of Intraoperative Dexamethasone and Ondansetron on Postoperative Nausea and Vomiting in Microvascular Decompression Surgery. clinicaltrials.gov/show/NCT03685032 (first received 26 September 2018). - PMC - PubMed
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- NCT03874936. The Effect of Perioperative Dexamethasone Administration on Postoperative Pain in Patients Undergoing Periacetabular Osteotomy. clinicaltrials.gov/show/NCT03874936 (first received 14 March 2019).
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- NCT03901768. Effects of Combined Topical and Systemic Steroid Administration on Better Early Postoperative Pain Management in Total Knee Arthroplasty. clinicaltrials.gov/show/NCT03901768 (first received 3 April 2019).
NCT04013386 {published data only}
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- NCT04013386. Effects of Aprepitant/Dexamethasone Versus Mirtazepine/Dexamethasone on Postoperative Nausea and Vomiting. clinicaltrials.gov/show/NCT04013386 (first received 9 July 2019).
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- NCT04027751. The Efficacy and Safety of Tropisetron in Preventing Emergence Delirium. clinicaltrials.gov/show/NCT04027751 (first received 22 July 2019).
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- PACTR201510001174606. Dexamethasone and Post Operative Nausea and Vomiting. who.int/trialsearch/Trial2.aspx?TrialID=PACTR201510001174606 (first received 16 June 2015).
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- PACTR201707002398224. Effect of Single-Dose Preoperative Dexamethasone on Postoperative Pain, Nausea and Vomiting Following Breast Surgery. who.int/trialsearch/Trial2.aspx?TrialID=PACTR201707002398224 (first received 01 July 2017).
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