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Review
. 2020 Oct 15;9(10):3309.
doi: 10.3390/jcm9103309.

Pancreatitis Associated with Viral Hepatitis: Systematic Review

Nikola Panic  1   2   3 , Sladjana Mihajlovic  1 , Miroslav Vujasinovic  3 , Milutin Bulajic  4 , Johannes-Matthias Löhr  3   5
Affiliations
Review

Pancreatitis Associated with Viral Hepatitis: Systematic Review

Nikola Panic et al. J Clin Med. .

Abstract

Background: We conducted a systematic review in order to summarize the available data on pancreatitis associated with viral hepatitis.

Methods: A comprehensive literature search of Medline, Scopus and ISI Web of Science databases was conducted and papers eligible for the inclusion identified.

Results: In total, 46 studies reporting data on 73 patients were included in the analysis. Most of the cases were diagnosed in Asia (57.53%), followed by North America (23.29%), and Europe (13.70%). Most of the patients were affected by hepatitis A virus (HAV) (42.47%), followed by hepatitis E virus (HEV) (28.77%), hepatitis B virus (HBV) (8.22%), and hepatitis C virus (HCV) (1.37%), while 17.81% at the time of diagnosis were classified as affected by "hepatitis virus". Pancreatitis was severe in 32.88% of cases. The respiratory system was affected in 2.74% of patients, 6.85% experienced renal failure, while 5.48% experienced a multiorgan dysfunction syndrome (MODS). Four patients (5.48%) needed pancreatic surgery. Despite the treatment, 21.92% of patients died. We identified fulminant hepatitis (p < 0.0001), MODS (p < 0.0001) and severe pancreatitis (p < 0.0001) to be significantly more present in patients who died in comparison to cured ones.

Conclusion: Increased awareness of pancreatic involvement in viral hepatitis is needed because it can have a substantial impact on therapeutic approaches and outcomes.

Keywords: hepatitis; pancreatitis; viral.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The search strategy and flow diagram for databases search.
See this image and copyright information in PMC

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