Parity and the risk of incident dementia: a COSMIC study

J B Bae^{1

2}, D M Lipnicki³, J W Han^{1

2}, P S Sachdev^{3

4}, T H Kim⁵, K P Kwak⁶, B J Kim⁷, S G Kim⁸, J L Kim⁹, S W Moon¹⁰, J H Park¹¹, S-H Ryu¹², J C Youn¹³, D Y Lee^{2

14}, D W Lee¹⁵, S B Lee¹⁶, J J Lee¹⁶, J H Jhoo¹⁷, I Skoog¹⁸, J Najar¹⁸, T R Sterner¹⁸, N Scarmeas^{19

20}, M Yannakoulia²¹, E Dardiotis²², S Riedel-Heller²³, S Roehr²³, A Pabst²³, D Ding^{24

25}, Q Zhao^{24

25}, X Liang^{24

25}, A Lobo^{26

27

28}, C De-la-Cámara^{26

27

28}, E Lobo^{26

27

28}, K W Kim^{1

2

29}; for Cohort Studies of Memory in an International Consortium (COSMIC)

Affiliations

¹ Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea.
² Department of Psychiatry, Seoul National University, College of Medicine, Seoul, South Korea.
³ Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia.
⁴ Dementia Collaborative Research Centre, University of New South Wales, Sydney, Australia.
⁵ Department of Psychiatry, Yonsei University Wonju Severance Christian Hospital, Wonju, South Korea.
⁶ Department of Psychiatry, Dongguk University Gyeongju Hospital, Gyeongju, South Korea.
⁷ Department of Psychiatry, Gyeongsang National University, School of Medicine, Jinju, South Korea.
⁸ Department of Neuropsychiatry, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea.
⁹ Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, South Korea.
¹⁰ Department of Psychiatry, School of Medicine, Konkuk University and Konkuk University Chungju Hospital, Chungju, South Korea.
¹¹ Department of Neuropsychiatry, Jeju National University Hospital, Jeju, South Korea.
¹² Department of Psychiatry, School of Medicine, Konkuk University and Konkuk University Medical Center, Seoul, South Korea.
¹³ Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Yongin, South Korea.
¹⁴ Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.
¹⁵ Department of Neuropsychiatry, Inje University Sanggye Paik Hospital, Seoul, South Korea.
¹⁶ Department of Psychiatry, Dankook University Hospital, Cheonan, South Korea.
¹⁷ Department of Neuropsychiatry, Kangwon National University Hospital, Chuncheon, South Korea.
¹⁸ Department of Psychiatry and Neurochemistry, Institute of Neuroscience of Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg, Sweden.
¹⁹ 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
²⁰ Department of Neurology, Columbia University, New York, USA.
²¹ Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
²² Neurology Department, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
²³ Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany.
²⁴ Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
²⁵ National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
²⁶ Department of Medicine and Psychiatry, Universidad de Zaragoza, Zaragoza, Spain.
²⁷ Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain.
²⁸ Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
²⁹ Department of Brain and Cognitive Science, Seoul National University College of Natural Sciences, Seoul, Korea.

PMID: 33077022
PMCID: PMC7681107
DOI: 10.1017/S2045796020000876

Parity and the risk of incident dementia: a COSMIC study

J B Bae et al. Epidemiol Psychiatr Sci. 2020.

. 2020 Oct 20:29:e176.

doi: 10.1017/S2045796020000876.

Authors

Affiliations

¹ Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea.
² Department of Psychiatry, Seoul National University, College of Medicine, Seoul, South Korea.
³ Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia.
⁴ Dementia Collaborative Research Centre, University of New South Wales, Sydney, Australia.
⁵ Department of Psychiatry, Yonsei University Wonju Severance Christian Hospital, Wonju, South Korea.
⁶ Department of Psychiatry, Dongguk University Gyeongju Hospital, Gyeongju, South Korea.
⁷ Department of Psychiatry, Gyeongsang National University, School of Medicine, Jinju, South Korea.
⁸ Department of Neuropsychiatry, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea.
⁹ Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, South Korea.
¹⁰ Department of Psychiatry, School of Medicine, Konkuk University and Konkuk University Chungju Hospital, Chungju, South Korea.
¹¹ Department of Neuropsychiatry, Jeju National University Hospital, Jeju, South Korea.
¹² Department of Psychiatry, School of Medicine, Konkuk University and Konkuk University Medical Center, Seoul, South Korea.
¹³ Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Yongin, South Korea.
¹⁴ Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.
¹⁵ Department of Neuropsychiatry, Inje University Sanggye Paik Hospital, Seoul, South Korea.
¹⁶ Department of Psychiatry, Dankook University Hospital, Cheonan, South Korea.
¹⁷ Department of Neuropsychiatry, Kangwon National University Hospital, Chuncheon, South Korea.
¹⁸ Department of Psychiatry and Neurochemistry, Institute of Neuroscience of Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg, Sweden.
¹⁹ 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
²⁰ Department of Neurology, Columbia University, New York, USA.
²¹ Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
²² Neurology Department, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
²³ Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany.
²⁴ Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
²⁵ National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
²⁶ Department of Medicine and Psychiatry, Universidad de Zaragoza, Zaragoza, Spain.
²⁷ Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain.
²⁸ Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
²⁹ Department of Brain and Cognitive Science, Seoul National University College of Natural Sciences, Seoul, Korea.

PMID: 33077022
PMCID: PMC7681107
DOI: 10.1017/S2045796020000876

Abstract

Aims: To investigate the association between parity and the risk of incident dementia in women.

Methods: We pooled baseline and follow-up data for community-dwelling women aged 60 or older from six population-based, prospective cohort studies from four European and two Asian countries. We investigated the association between parity and incident dementia using Cox proportional hazards regression models adjusted for age, educational level, hypertension, diabetes mellitus and cohort, with additional analysis by dementia subtype (Alzheimer dementia (AD) and non-Alzheimer dementia (NAD)).

Results: Of 9756 women dementia-free at baseline, 7010 completed one or more follow-up assessments. The mean follow-up duration was 5.4 ± 3.1 years and dementia developed in 550 participants. The number of parities was associated with the risk of incident dementia (hazard ratio (HR) = 1.07, 95% confidence interval (CI) = 1.02-1.13). Grand multiparity (five or more parities) increased the risk of dementia by 30% compared to 1-4 parities (HR = 1.30, 95% CI = 1.02-1.67). The risk of NAD increased by 12% for every parity (HR = 1.12, 95% CI = 1.02-1.23) and by 60% for grand multiparity (HR = 1.60, 95% CI = 1.00-2.55), but the risk of AD was not significantly associated with parity.

Conclusions: Grand multiparity is a significant risk factor for dementia in women. This may have particularly important implications for women in low and middle-income countries where the fertility rate and prevalence of grand multiparity are high.

Keywords: Dementia; geriatric psychiatry; risk factors; women.

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Conflict of interest statement

None.

References

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Parity and the risk of incident dementia: a COSMIC study

Affiliations

Parity and the risk of incident dementia: a COSMIC study

Authors

Affiliations

Abstract

Conflict of interest statement

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical