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Comment
. 2020 Dec;146(6):1455-1456.
doi: 10.1016/j.jaci.2020.09.008. Epub 2020 Sep 29.

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Koa Hosoki  1 , Jason T Kimata  2 , Abhijit Chakraborty  1 , Sanjiv Sur  3
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Comment

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Koa Hosoki et al. J Allergy Clin Immunol. 2020 Dec.
No abstract available

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Figures

Fig 1
Fig 1
A, Illustration showing several postulated mechanisms of SARS-CoV-2–induced pulmonary edema. B, Presence of pseudotype virus detected by luciferase activity in the lysate of Caco-2 cells. Caco-2 cells were infected with SARS-CoV-2 spike-HIV-luc pseudotype virus at 5 × 103 infectious units/mL. Thus, the luciferase reporter activity serves as a measure of viral particles in the infected cells. After 24 hours of incubation, luciferase levels in the cell lysates were quantified. C, IFN-λ2 mRNA expression in Caco-2 cells incubated with or without SARS-CoV-2 spike-HIV-luc pseudotype virus for 24 hours. N = 3 to 6 per group were used. Data are expressed as means ± SEM. ∗∗P < .01, ∗∗∗P < .001.
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References

    1. Zwaveling S., van Wijk R.G., Karim F. Pulmonary edema in COVID-19: explained by bradykinin? J Allergy Clin Immunol. 2020;146:1454–1455. - PMC - PubMed
    1. Hosoki K., Chakraborty A., Sur S. Molecular mechanisms and epidemiology of COVID-19 from an allergist’s perspective. J Allergy Clin Immunol. 2020;146:285–299. - PMC - PubMed
    1. Imai Y., Kuba K., Rao S., Huan Y., Guo F., Guan B. Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature. 2005;436:112–116. - PMC - PubMed
    1. Kuba K., Imai Y., Rao S., Gao H., Guo F., Guan B. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med. 2005;11:875–879. - PMC - PubMed
    1. Ackermann M., Verleden S.E., Kuehnel M., Haverich A., Welte T., Laenger F. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N Engl J Med. 2020;383:120–128. - PMC - PubMed

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