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Comment
. 2020 Dec;28(12):952-954.
doi: 10.1016/j.tim.2020.10.002. Epub 2020 Oct 10.

Sex-biased Immune Responses Following SARS-CoV-2 Infection

Rebecca L Ursin  1 , Janna R Shapiro  2 , Sabra L Klein  3
Affiliations
Comment

Sex-biased Immune Responses Following SARS-CoV-2 Infection

Rebecca L Ursin et al. Trends Microbiol. 2020 Dec.

Abstract

Males are disproportionately affected by severe disease and death from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In their recent article, Takahashi et al. found sex differences in immune responses to SARS-CoV-2 and the predictors of disease progression. These findings contribute to elucidating the mechanisms that underlie the male bias in severe disease and death from coronavirus disease 2019 (COVID-19).

Keywords: COVID-19; SARS-CoV-2; biological sex; immunopathogenesis.

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Comment on

  • Sex differences in immune responses that underlie COVID-19 disease outcomes.
    Takahashi T, Ellingson MK, Wong P, Israelow B, Lucas C, Klein J, Silva J, Mao T, Oh JE, Tokuyama M, Lu P, Venkataraman A, Park A, Liu F, Meir A, Sun J, Wang EY, Casanovas-Massana A, Wyllie AL, Vogels CBF, Earnest R, Lapidus S, Ott IM, Moore AJ; Yale IMPACT Research Team; Shaw A, Fournier JB, Odio CD, Farhadian S, Dela Cruz C, Grubaugh ND, Schulz WL, Ring AM, Ko AI, Omer SB, Iwasaki A. Takahashi T, et al. Nature. 2020 Dec;588(7837):315-320. doi: 10.1038/s41586-020-2700-3. Epub 2020 Aug 26. Nature. 2020. PMID: 32846427 Free PMC article.

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