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Review
. 2020;9(4):323-330.
doi: 10.1007/s13671-020-00315-0. Epub 2020 Oct 14.

Vitamin D Update

Affiliations
Review

Vitamin D Update

Mary S Matsui. Curr Dermatol Rep. 2020.

Abstract

Purpose: The goal of this review is to provide an update in the field of vitamin D, in particular, the role of vitamin D in non-skeletal health, the complexity of providing patient guidance regarding obtaining sufficient vitamin D, and the possible involvement of vitamin D in morbidity and mortality due to SARS-CoV-2 (COVID-19).

Recent findings: In addition to bone health, vitamin D may play a role in innate immunity, cardiovascular disease, and asthma. Although rickets is often regarded as an historical disease of the early twentieth century, it appears to be making a comeback worldwide, including "first-world" countries. Broad-spectrum sunscreens (with high UVA filters) that prevent erythema are unlikely to compromise vitamin D status in healthy populations.

Summary: New attention is now focused on the role of vitamin D in a variety of diseases, and more individualized patient recommendation schemes are being considered that take into account more realistic and achievable goals for achieving sufficient vitamin D through diet, supplements, and sun behavior.

Keywords: Osteomalacia; Pigmentation; Rickets; Sunscreen; Ultraviolet light; Vitamin D.

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References

    1. DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004;80(6):1689S–96S. 10.1093/ajcn/80.6.1689S. This is a generally helpful primer on the classic functions and understanding of vitamin D. - PubMed
    1. Jorde R, Grimnes G. Vitamin D and health: the need for more randomized controlled trials. J Steroid Biochem Mol Biol. 2015;148:269–274. doi: 10.1016/j.jsbmb.2015.01.021. - DOI - PubMed
    1. Jorde R, Grimnes G. Serum cholecalciferol may be a better marker of vitamin D status than 25-hydroxyvitamin D. Med Hypotheses. 2018;111:61–65. doi: 10.1016/j.mehy.2017.12.017. - DOI - PubMed
    1. Brustad N, Garland J, Thorsen J, Sevelsted A, Krakauer M, Vinding RK, et al. Effect of high-dose vs standard-dose vitamin D supplementation in pregnancy on bone mineralization in offspring until age 6 years: a prespecified secondary analysis of a double-blinded, Randomized Clinical Trial. JAMA Pediatr. 2020;174(5):419–27. 10.1001/jamapediatrics.2019.6083. - PMC - PubMed
    1. Wheeler BJ, Snoddy AME, Munns C, Simm P, Siafarikas A, Jefferies C. A brief history of nutritional rickets. Front Endocrinol (Lausanne). 2019;10:795. 10.3389/fendo.2019.00795. An important update on current issues in vitamin D status in multiple populations. - PMC - PubMed

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