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Review
. 2021 Mar;58(3):1017-1023.
doi: 10.1007/s12035-020-02177-w. Epub 2020 Oct 19.

Neurobiochemical Cross-talk Between COVID-19 and Alzheimer's Disease

Mohammad Azizur Rahman  1 , Kamrul Islam  2 , Saidur Rahman  3 , Md Alamin  4
Affiliations
Review

Neurobiochemical Cross-talk Between COVID-19 and Alzheimer's Disease

Mohammad Azizur Rahman et al. Mol Neurobiol. 2021 Mar.

Abstract

COVID-19, the global threat to humanity, shares etiological cofactors with multiple diseases including Alzheimer's disease (AD). Understanding the common links between COVID-19 and AD would harness strategizing therapeutic approaches against both. Considering the urgency of formulating COVID-19 medication, its AD association and manifestations have been reviewed here, putting emphasis on memory and learning disruption. COVID-19 and AD share common links with respect to angiotensin-converting enzyme 2 (ACE2) receptors and pro-inflammatory markers such as interleukin-1 (IL-1), IL-6, cytoskeleton-associated protein 4 (CKAP4), galectin-9 (GAL-9 or Gal-9), and APOE4 allele. Common etiological factors and common manifestations described in this review would aid in developing therapeutic strategies for both COVID-19 and AD and thus impact on eradicating the ongoing global threat. Thus, people suffering from COVID-19 or who have come round of it as well as people at risk of developing AD or already suffering from AD, would be benefitted.

Keywords: ACE2; ApoE4; Gal-9; Inflammation; Neuroinvasive.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Fig. 1
Fig. 1
Concordant and disconcordant cross-talk between AD and COVID-19
See this image and copyright information in PMC

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