Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Dec;25(8):1107-1116.
doi: 10.1007/s00775-020-01827-7. Epub 2020 Oct 20.

Mitochondria-targeted Re(I) complexes bearing guanidinium as ligands and their anticancer activity

Shu-Fen He #  1   2 , Nan-Lian Pan #  1 , Bing-Bing Chen  1 , Jia-Xin Liao  1 , Min-Ying Huang  1 , Hai-Jun Qiu  1 , Dong-Chun Jiang  1 , Jun-Jie Wang  1 , Jia-Xi Chen  3 , Jing Sun  4
Affiliations

Mitochondria-targeted Re(I) complexes bearing guanidinium as ligands and their anticancer activity

Shu-Fen He et al. J Biol Inorg Chem. 2020 Dec.

Abstract

As the "powerhouse" of a cell, mitochondria maintain energy homeostasis, synthesize ATP via oxidative phosphorylation, generate ROS signaling molecules, and modulate cell apoptosis. Herein, three Re(I) complexes bearing guanidinium derivatives have been synthesized and characterized. All of these complexes exhibit moderate anticancer activity in HepG2, HeLa, MCF-7, and A549 cancer cells. Mechanism studies indicate that complex 3, [Re(CO)3(L)(Im)](PF6)2, can selectively localize in the mitochondria and induce cancer cell death through mitochondria-associated pathways. In addition, complex 3 can effectively depress the ability of cell migration, cell invasion, and colony formation.

Keywords: Apoptosis; Cytotoxicity; Mitochondria; Re(I) complex.

PubMed Disclaimer

References

    1. Guerra F, Arbini AA, Moro L (2017) Biochim Biophys Acta 1858:686–699
    1. Galluzzi L, Morselli E, Kepp O, Vitale I, Rigoni A, Vacchelli E, Michaud M, Zischka H, Castedo M, Kroemer G (2009) Mol Asp Med 31:1–20
    1. Kumar R, Han J, Lim HJ, Ren WX, Lim JY, Kim JH, Kim JS (2014) J Am Chem Soc 136:17836–17843 - PubMed
    1. Fulda S, Galluzzi L, Kroemer G (2010) Nat Rev Drug Discov 9:447–464 - PubMed
    1. Battogtokh G, Choi YS, Kang DS, Park SJ, Shim MS, Huh KM, Cho YY, Lee JY, Lee HS, Kang HC (2018) Acta Pharm Sin B 8:862–880 - PubMed - PMC

Publication types

LinkOut - more resources