Role of flavonoids against adriamycin toxicity

María D Navarro-Hortal¹, Alfonso Varela-López², José M Romero-Márquez³, Lorenzo Rivas-García⁴, Lorenza Speranza⁵, Maurizio Battino⁶, José L Quiles⁷

Affiliations

¹ Biomedical Research Centre, Institute of Nutrition and Food Technology "José Mataix Verdú", Department of Physiology, University of Granada, Avda. del Conocimiento s/n, 18100, Armilla, Granada, Spain. Electronic address: mdnavarro@ugr.es.
² Biomedical Research Centre, Institute of Nutrition and Food Technology "José Mataix Verdú", Department of Physiology, University of Granada, Avda. del Conocimiento s/n, 18100, Armilla, Granada, Spain. Electronic address: alvarela@ugr.es.
³ Biomedical Research Centre, Institute of Nutrition and Food Technology "José Mataix Verdú", Department of Physiology, University of Granada, Avda. del Conocimiento s/n, 18100, Armilla, Granada, Spain. Electronic address: romeromarquez@ugr.es.
⁴ Biomedical Research Centre, Institute of Nutrition and Food Technology "José Mataix Verdú", Department of Physiology, University of Granada, Avda. del Conocimiento s/n, 18100, Armilla, Granada, Spain; Sport and Health Research Centre, University of Granada, C/. Menéndez Pelayo 32, 18016, Armilla, Granada, Spain. Electronic address: lorenrivas@ugr.es.
⁵ Department of Medicine and Aging Sciences, University "G. d'Annunzio" Chieti-Pescara, Via dei Vestini 31, 66100, CH, Italy. Electronic address: lorenza.speranza@unich.it.
⁶ Department of Clinical Sicences, Università Politecnica delle Marche, 60131, Ancona, Italy; International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, 212013, China. Electronic address: m.a.battino@staff.univpm.it.
⁷ Biomedical Research Centre, Institute of Nutrition and Food Technology "José Mataix Verdú", Department of Physiology, University of Granada, Avda. del Conocimiento s/n, 18100, Armilla, Granada, Spain. Electronic address: jlquiles@ugr.es.

PMID: 33080329
DOI: 10.1016/j.fct.2020.111820

Review

Role of flavonoids against adriamycin toxicity

María D Navarro-Hortal et al. Food Chem Toxicol. 2020 Dec.

. 2020 Dec:146:111820.

doi: 10.1016/j.fct.2020.111820. Epub 2020 Oct 17.

Authors

María D Navarro-Hortal¹, Alfonso Varela-López², José M Romero-Márquez³, Lorenzo Rivas-García⁴, Lorenza Speranza⁵, Maurizio Battino⁶, José L Quiles⁷

Affiliations

¹ Biomedical Research Centre, Institute of Nutrition and Food Technology "José Mataix Verdú", Department of Physiology, University of Granada, Avda. del Conocimiento s/n, 18100, Armilla, Granada, Spain. Electronic address: mdnavarro@ugr.es.
² Biomedical Research Centre, Institute of Nutrition and Food Technology "José Mataix Verdú", Department of Physiology, University of Granada, Avda. del Conocimiento s/n, 18100, Armilla, Granada, Spain. Electronic address: alvarela@ugr.es.
³ Biomedical Research Centre, Institute of Nutrition and Food Technology "José Mataix Verdú", Department of Physiology, University of Granada, Avda. del Conocimiento s/n, 18100, Armilla, Granada, Spain. Electronic address: romeromarquez@ugr.es.
⁴ Biomedical Research Centre, Institute of Nutrition and Food Technology "José Mataix Verdú", Department of Physiology, University of Granada, Avda. del Conocimiento s/n, 18100, Armilla, Granada, Spain; Sport and Health Research Centre, University of Granada, C/. Menéndez Pelayo 32, 18016, Armilla, Granada, Spain. Electronic address: lorenrivas@ugr.es.
⁵ Department of Medicine and Aging Sciences, University "G. d'Annunzio" Chieti-Pescara, Via dei Vestini 31, 66100, CH, Italy. Electronic address: lorenza.speranza@unich.it.
⁶ Department of Clinical Sicences, Università Politecnica delle Marche, 60131, Ancona, Italy; International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, 212013, China. Electronic address: m.a.battino@staff.univpm.it.
⁷ Biomedical Research Centre, Institute of Nutrition and Food Technology "José Mataix Verdú", Department of Physiology, University of Granada, Avda. del Conocimiento s/n, 18100, Armilla, Granada, Spain. Electronic address: jlquiles@ugr.es.

PMID: 33080329
DOI: 10.1016/j.fct.2020.111820

Abstract

Doxorubicin (DOX), or adriamycin, is an anthracycline antineoplastic drug widely used in the chemotherapy of a large variety of cancers due to its potency and action spectrum. However, its use is limited by the toxicity on healthy cells and its acute and chronic side effects. One of the developed strategies to attenuate DOX toxicity is the combined therapy with bioactive compounds such as flavonoids. This review embraces the role of flavonoids on DOX treatment side effects. Protective properties of some flavonoidss against DOX toxicity have been investigated and observed mainly in heart but also in liver, kidney, brain, testis or bone marrow. Protective mechanisms involve reduction of oxidative stress by decrease of ROS levels and/or increase antioxidant defenses and interferences with autophagy, apoptosis and inflammation. Studies in cancer cells have reported that the anticancer activity of DOX was not compromised by the flavonoids. Moreover, some of them increased DOX efficiency as anti-cancer drug even in multidrug resistant cells.

Keywords: Apigenin; Catechin; EGCG; Proanthocyanidins; Quercetin; Rutin.

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Role of flavonoids against adriamycin toxicity

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Role of flavonoids against adriamycin toxicity

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