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Review
. 2020 Oct 16;12(10):1172.
doi: 10.3390/v12101172.

Viral Related Tools against SARS-CoV-2

Laura Fernandez-Garcia  1   2 , Olga Pacios  1   2 , Mónica González-Bardanca  1   2 , Lucia Blasco  1   2 , Inés Bleriot  1   2 , Antón Ambroa  1   2 , María López  1   2 , German Bou  1   2   3 , Maria Tomás  1   2   3
Affiliations
Review

Viral Related Tools against SARS-CoV-2

Laura Fernandez-Garcia et al. Viruses. .

Abstract

At the end of 2019, a new disease appeared and spread all over the world, the COVID-19, produced by the coronavirus SARS-CoV-2. As a consequence of this worldwide health crisis, the scientific community began to redirect their knowledge and resources to fight against it. Here we summarize the recent research on viruses employed as therapy and diagnostic of COVID-19: (i) viral-vector vaccines both in clinical trials and pre-clinical phases; (ii) the use of bacteriophages to find antibodies specific to this virus and some studies of how to use the bacteriophages themselves as a treatment against viral diseases; and finally, (iii) the use of CRISPR-Cas technology both to obtain a fast precise diagnose of the patient and also the possible use of this technology as a cure.

Keywords: COVID-19; CRISPR; SARS-CoV-2; diagnosis; phages; prevention; treatment; viruses.

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Conflict of interest statement

All authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Uses of phage-display libraries in the diagnostic (1, 2 y 3) and treatment (4, 5, and 6) of SARS-CoV-2. scFv: single-chain variable fragment. S2: spike subunit 2. mAbs: monoclonal antibodies. MERS: Middle-East respiratory syndrome. RBD: receptor-binding protein.
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References

    1. Drosten C., Günther S., Preiser W., van der Werf S., Brodt H.R., Becker S., Rabenau H., Panning M., Kolesnikova L., Fouchier R.A., et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N. Engl. J. Med. 2003;348:1967–1976. doi: 10.1056/NEJMoa030747. - DOI - PubMed
    1. Ksiazek T.G., Erdman D., Goldsmith C.S., Zaki S.R., Peret T., Emery S., Tong S., Urbani C., Comer J.A., Lim W., et al. A novel coronavirus associated with severe acute respiratory syndrome. N. Engl. J. Med. 2003;348:1953–1966. doi: 10.1056/NEJMoa030781. - DOI - PubMed
    1. Cui J., Li F., Shi Z.L. Origin and evolution of pathogenic coronaviruses. Nat. Rev. Microbiol. 2019;17:181–192. doi: 10.1038/s41579-018-0118-9. - DOI - PMC - PubMed
    1. Zhou P., Yang X.L., Wang X.G., Hu B., Zhang L., Zhang W., Si H.R., Zhu Y., Li B., Huang C.L., et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579:270–273. doi: 10.1038/s41586-020-2012-7. - DOI - PMC - PubMed
    1. Khan M.N., Sarker M. A review of Coronavirus 2019 COVID-19 a life threating disease all over the world. World Cancer Res. J. 2020;7:e1586. doi: 10.32113/wcrj_20205_1586. - DOI

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