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. 2020 Oct 20;20(1):422.
doi: 10.1186/s12886-020-01693-6.

The changes of corneal biomechanical properties with long-term treatment of prostaglandin analogue measured by Corvis ST

Na Wu  1   2   3 , Yuhong Chen  4   5   6 , Yaping Yang  1   2   3 , Xinghuai Sun  1   2   3   7
Affiliations

The changes of corneal biomechanical properties with long-term treatment of prostaglandin analogue measured by Corvis ST

Na Wu et al. BMC Ophthalmol. .

Abstract

Background: To investigate the corneal biomechanical changes in primary open angle glaucoma (POAG) patients treated with long-term prostaglandin analogue (PGA).

Methods: One hundred eleven newly diagnosed POAG patients, including 43 high tension glaucoma (HTG) and 68 normal tension glaucoma (NTG), were measured by Corvis ST to obtain intraocular pressure (IOP), central corneal thickness (CCT) and corneal biomechanical parameters at baseline and at each follow-up visit after initiation of PGA treatment. The follow-up measurements were analyzed by the generalized estimate equation model with an exchangeable correlation structure. Restricted cubic spline was employed to estimate the dose-response relation between follow-up time and corneal biomechanics.

Results: The mean follow-up time was 10.3 ± 7.02 months. Deformation amplitude (β = -0.0015, P = 0.016), the first applanation velocity (AV1, β = -0.0004, P = 0.00058) decreased and the first applanation time (AT1, β = 0.0089, P < 0.000001) increased statistically significantly with PGA therapy over time after adjusting for age, gender, axial length, corneal curvature, IOP and CCT. In addition, AT1 was lower (7.2950 ± 0.2707 in NTG and 7.5889 ± 0.2873 in HTG, P = 0.00011) and AV1 was greater (0.1478 ± 0.0187 in NTG and 0.1314 ± 0.0191 in HTG, P = 0.00002) in NTG than in HTG after adjusting for confounding factors.

Conclusions: Chronic use of PGA probably influences the corneal biomechanical properties directly, which is to make cornea less deformable. Besides, corneas in NTG tended to be more deformable compared to those in HTG with long-term treatment of PGA.

Keywords: Corneal biomechanical properties; Corvis ST; Glaucoma; Prostaglandin analogue.

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Conflict of interest statement

The authors declare that they have no competing interest.

Figures

Fig. 1
Fig. 1
The changes of IOP (a), bIOP (b) and CCT (c) in POAG patients under PGA treatment over time
Fig. 2
Fig. 2
The changes of DA (a), AT1 (b), AV1 (c) and AT2 (d) in POAG patients under PGA treatment over time
Fig. 3
Fig. 3
The changes of AT1 (a) and AV1 (b) in NTG and HTG patients under PGA treatment over time
See this image and copyright information in PMC

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