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Case Reports
. 2020 Aug;49(8):1564-1568.
doi: 10.18502/ijph.v49i8.3903.

First Cases of SARS-CoV-2 in Iran, 2020: Case Series Report

Jila Yavarian  1 , Nazanin-Zahra Shafiei-Jandaghi  1 , Kaveh Sadeghi  1 , Somayeh Shatizadeh Malekshahi  2 , Vahid Salimi  1 , Ahmad Nejati  1 , Fatemeh Aja-Minejad  1 , Nastaran Ghavvami  1 , Fatemeh Saadatmand  1 , Saeedeh Mahfouzi  1 , Ghazal Fateminasab  1 , Najmeh Parhizgari  1 , Akramsadat Ahmadi  1 , Kobra Razavi  1 , Soad Ghabeshi  1 , Mostafa Saberian  3 , Elham Zanjani  1 , Fatemeh Namazi  4 , Tayebeh Shahbazi  5 , Farshid Rezaie  6 , Hossein Erfani  6 , Mohammad Mehdi Gouya  6 , Mohammad Nasr Dadras  6 , Talat Mokhtari Azad  1
Affiliations
Case Reports

First Cases of SARS-CoV-2 in Iran, 2020: Case Series Report

Jila Yavarian et al. Iran J Public Health. 2020 Aug.

Abstract

In Jan 2020, the outbreak of the 2019 novel coronavirus (SARS-CoV-2) in Wuhan, Hubei Province of China spread increasingly to other countries worldwide which WHO declared it as a public health emergency of international concern. Iran was included in the affected countries. Throat swab specimens were collected and tested by using real-time reverse transcription PCR (RT-PCR) kit targeting the E region for screening and RNA dependent RNA polymerase for confirmation. Conventional RT-PCR was conducted for the N region and the PCR products were sequenced by Sanger sequencing. The first seven cases of SARS-CoV-2 infections were identified in Qom, Iran. This report describes the clinical and epidemiological features of the first cases of SARS-CoV-2 confirmed in Iran. Future research should focus on finding the routes of transmission for this virus, including the possibility of transmission from foreign tourists to identify the possible origin of SARS-CoV-2 outbreak in Iran.

Keywords: COVID-19; Emerging disease; Iran; SARS-CoV-2; Virus.

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Conflict of interest statement

Conflicts of interest The authors have no conflicts of interest to declare.

Figures

Fig. 1:
Fig. 1:
Phylogenic sequence analysis of SARS-CoV-2 N gene detected from patients in Qom, Iran (red circles), 2020, compared with sequences from GSAID. The reference sequence is shown with yellow triangle. MEGA X software was used for construction of Maximum likelihood tree by using the Jukes-Cantor model as chosen by best-fit substitution model
See this image and copyright information in PMC

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