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. 2020 Oct 6;8(19):4380-4387.
doi: 10.12998/wjcc.v8.i19.4380.

Percutaneous radiofrequency ablation is superior to hepatic resection in patients with small hepatocellular carcinoma

Yan-Hua Zhang  1 , Bo Su  2 , Pei Sun  2 , Ru-Meng Li  2 , Xiao-Chun Peng  2 , Jun Cai  3
Affiliations

Percutaneous radiofrequency ablation is superior to hepatic resection in patients with small hepatocellular carcinoma

Yan-Hua Zhang et al. World J Clin Cases. .

Abstract

Background: It is not known whether percutaneous radiofrequency ablation (PRFA) has the same treatment efficacy and fewer complications than laparoscopic resection in patients with small centrally located hepatocellular carcinoma (HCC).

Aim: To compare the effectiveness of PRFA with classical laparoscopic resection in patients with small HCC and document the safety parameters.

Methods: In this retrospective study, 85 patients treated with hepatic resection (HR) and 90 PRFA-treated patients were enrolled in our hospital from July 2016 to July 2019. Treatment outcomes, including major complications and survival data, were evaluated.

Results: The results showed that minor differences existed in the baseline characteristics between the patients in the two groups. PRFA significantly increased cumulative recurrence-free survival (hazard ratio 1.048, 95%CI: 0.265-3.268) and overall survival (hazard ratio 0.126, 95%CI: 0.025-0.973); PRFA had a lower rate of major complications than HR (7.78% vs 20.0%, P < 0.05), and hospital stay was shorter in the PRFA group than in the HR group (7.8 ± 0.2 d vs 9.5 ± 0.3 d, P < 0.001).

Conclusion: Based on the data obtained, we conclude that PRFA was superior to HR and may reduce complications and hospital stay in patients with small HCC.

Keywords: Cancer; Efficacy; Hepatic resection; Hepatocellular carcinoma; Percutaneous radiofrequency ablation; Safety.

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Conflict of interest statement

Conflict-of-interest statement: No potential conflicts of interest were disclosed.

Figures

Figure 1
Figure 1
Comparison of cumulative recurrence-free survival and overall survival of patients with hepatocellular carcinoma treated with hepatic resection or percutaneous radiofrequency ablation. A: Cumulative recurrence-free survival; B: overall survival of patients. PRFA: Percutaneous radiofrequency ablation; HR: Hepatic resection.
Figure 2
Figure 2
Kaplan–Meier curves of cumulative recurrence-free survival and overall survival of patients with hepatocellular carcinoma treated with hepatic resection or percutaneous radiofrequency ablation. A: Cumulative recurrence-free survival; B: Overall survival of patients. PRFA: Percutaneous radiofrequency ablation; HR: Hepatic resection.
See this image and copyright information in PMC

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