Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Jul;71(1):23-9.

In vitro responses of airways from an asthmatic patient

J C de Jongste  1 , H Mons, I L Bonta, K F Kerrebijn
Affiliations
  • PMID: 3308503

In vitro responses of airways from an asthmatic patient

J C de Jongste et al. Eur J Respir Dis. 1987 Jul.

Abstract

Responses of isolated human airways, obtained from a single asthmatic patient at thoracotomy, were compared to responses of airways from 10 non-asthmatic subjects in vitro. Asthmatic bronchiolar strips exhibited increased contractile responses to histamine, methacholine and leukotriene (LT) C4, and relaxed normally in response to 1-isoprenaline and forskolin. The non-adrenergic inhibitory response to field stimulation was low, but was not significantly different from control values. These results suggest that increased airway smooth muscle contractility may contribute to the asthmatic airways hyperresponsiveness in this patient.

PubMed Disclaimer

Publication types