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Book

Oropharyngeal Squamous Cell Carcinoma

Zohaib Jamal  1 , Fatima Anjum  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Oropharyngeal Squamous Cell Carcinoma

Zohaib Jamal et al.
Free Books & Documents

Excerpt

Oropharyngeal squamous cell carcinoma (OPSCC), commonly known as throat cancer or tonsil cancer, refers to the cancer of the middle part of the pharynx, known as the oropharynx, which extends vertically from the soft palate to the superior area of the hyoid bone and includes the base and posterior one-third of the tongue, the tonsils, soft palate, and posterior and lateral pharyngeal walls.

More than 90% of oropharyngeal cancers are squamous cell cancers, which are the cell lining of the oropharynx .

Two types of oropharyngeal cancer can be distinguished: HPV-associated, due to an oral human papillomavirus infection, and non-HPV-associated, mainly due to tobacco smoking and alcohol use.

In addition to the direct invasion of the tissues, oropharyngeal cancer can spread through blood and lymphatics. The major symptoms of oropharyngeal cancer include sore throat, odynophagia, and dysphagia. Diagnosis is made based on biopsy results of the affected tissue. Treatment involves surgery, radiotherapy, chemotherapy, or a combination of these therapies.

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Conflict of interest statement

Disclosure: Zohaib Jamal declares no relevant financial relationships with ineligible companies.

Disclosure: Fatima Anjum declares no relevant financial relationships with ineligible companies.

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