Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2020 Oct 19;12(10):3187.
doi: 10.3390/nu12103187.

Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients

Tatsunori Toida  1   2 , Reiko Toida  3 , Shou Ebihara  4 , Risa Takahashi  2 , Hiroyuki Komatsu  5 , Shigehiro Uezono  3 , Yuji Sato  6 , Shouichi Fujimoto  1
Affiliations
Observational Study

Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients

Tatsunori Toida et al. Nutrients. .

Abstract

Background: The relationships between serum zinc levels and body composition or clinical outcomes of incident hemodialysis (HD) patients remain unclear.

Methods: This prospective observational study examined the relationships between serum zinc levels and clinical indexes, including body composition, in 142 incident HD patients using a bioelectrical impedance analysis. Patients were divided into three groups according to baseline serum zinc levels: tertile, <45, 45-59, and ≥60 µg/dL. The reference group was set as ≥60 µg/dL. Cox's regression analysis was performed to investigate the relationships between serum zinc categories and cardiovascular events and all-cause mortality after adjustments for potential confounders.

Results: Serum zinc levels positively correlated with the nutritional index and negatively correlated with fluid volume markers. In a mean follow-up of 2.5 years, there were 20 cases of cardiovascular events and 15 of all-cause mortality. In the Cox's regression analysis for cardiovascular events and all-cause mortality, the hazard ratio increased with a decrease in serum zinc levels, but was not significant.

Conclusion: Serum zinc levels were associated with nutritional and fluid volume markers in incident HD patients. To clarify the relationship between serum zinc levels and cardiovascular events or mortality, further studies with a larger number of cases will be necessary.

Keywords: hemodialysis; nutritional status; serum zinc levels.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow of patients through the study.
Figure 2
Figure 2
Histogram of serum zinc levels at baseline.
Figure 3
Figure 3
Kaplan–Meier estimates and Log rank test for all-cause mortality (a) and cardiovascular disease (CVD)-free (b) rates among baseline serum zinc levels.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Tonelli M., Network T.A.K.D., Wiebe N., Hemmelgarn B., Klarenbach S., Field C., Manns B., Thadhani R., Gill J. The Alberta Kidney Disease Network. Trace elements in hemodialysis patients: A systematic review and meta-analysis. BMC Med. 2009;7:25. doi: 10.1186/1741-7015-7-25. - DOI - PMC - PubMed
    1. Alker W., Haase H. Zinc and Sepsis. Nutrients. 2018;10:976. doi: 10.3390/nu10080976. - DOI - PMC - PubMed
    1. Gammoh N.Z., Rink L. Zinc in Infection and Inflammation. Nutrients. 2017;9:624. doi: 10.3390/nu9060624. - DOI - PMC - PubMed
    1. Reiterer G., Macdonald R., Browning J.D., Morrow J., Matveev S.V., Daugherty A., Smart E., Toborek M., Hennig B. Zinc Deficiency Increases Plasma Lipids and Atherosclerotic Markers in LDL-Receptor–Deficient Mice. J. Nutr. 2005;135:2114–2118. doi: 10.1093/jn/135.9.2114. - DOI - PubMed
    1. Cardozo L.F.M.F., Mafra D. Don’t forget the zinc. Nephrol. Dial. Transplant. 2020;35:1094–1098. doi: 10.1093/ndt/gfaa045. - DOI - PubMed

Publication types