The Macro- and Micro-Mechanics of the Colon and Rectum I: Experimental Evidence

Abstract

Many lower gastrointestinal diseases are associated with altered mechanical movement and deformation of the large intestine, i.e., the colon and rectum. The leading reason for patients' visits to gastrointestinal clinics is visceral pain, which is reliably evoked by mechanical distension rather than non-mechanical stimuli such as inflammation or heating. The macroscopic biomechanics of the large intestine were characterized by mechanical tests and the microscopic by imaging the load-bearing constituents, i.e., intestinal collagen and muscle fibers. Regions with high mechanical stresses in the large intestine (submucosa and muscularis propria) coincide with locations of submucosal and myenteric neural plexuses, indicating a functional interaction between intestinal structural biomechanics and enteric neurons. In this review, we systematically summarized experimental evidence on the macro- and micro-scale biomechanics of the colon and rectum in both health and disease. We reviewed the heterogeneous mechanical properties of the colon and rectum and surveyed the imaging methods applied to characterize collagen fibers in the intestinal wall. We also discussed the presence of extrinsic and intrinsic neural tissues within different layers of the colon and rectum. This review provides a foundation for further advancements in intestinal biomechanics by synergistically studying the interplay between tissue biomechanics and enteric neurons.

Keywords: colorectum; experiments; large intestine; mechanotransduction; multi-layered.

Figure 1

The layered structure of the large intestine. Subm. plx. = submucosal plexus; Myet. plx. = myenteric plexus; C. muscle = circular muscle layer; L. muscle = longitudinal muscle layer. Adapted from [44] with permission.

Figure 2

Schematic diagram showing the cylindrical coordinates of the large intestine in circumferential, radial, and longitudinal directions.