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Review
. 2020 Oct;5(5):e000718.
doi: 10.1136/esmoopen-2020-000718.

Aurora kinases in ovarian cancer

J Alejandro Pérez-Fidalgo  1 , Valentina Gambardella  2 , Begoña Pineda  3 , Octavio Burgues  4 , Oscar Piñero  5 , Andrés Cervantes  6
Affiliations
Review

Aurora kinases in ovarian cancer

J Alejandro Pérez-Fidalgo et al. ESMO Open. 2020 Oct.

Abstract

Aurora kinases (AURK) are key regulators of the mitotic spindle formation. AURK is frequently overexpressed in ovarian cancer and this overexpression has been frequently associated with prognosis in these tumours. Interestingly, AURK have been shown to interact with DNA repair mechanisms and other cell cycle regulators. These functions have brought light to Aurora family as a potential target for anticancer therapy. In the last years, two clinical trials with different AURK inhibitors have shown activity in epithelial and clear-cell ovarian cancer. Although there is a lack of predictive factors of AURK inhibition activity, recent trials have identified some candidates. This review will focus in the functions of the AURK family, its role as prognostic factor in epithelial ovarian cancer and potential clinical implications.

Keywords: aurora inhibitors; aurora kinase; ovarian cancer.

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Conflict of interest statement

Competing interests: None declared.

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