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Comment
. 2021 Sep;70(9):1799-1800.
doi: 10.1136/gutjnl-2020-322621. Epub 2020 Oct 21.

Hepatic inflammasome activation as origin of Interleukin-1α and Interleukin-1β in liver cirrhosis

Michael Praktiknjo  1 , Robert Schierwagen  2 , Sofia Monteiro  1   3 , Cristina Ortiz  2 , Frank Erhard Uschner  2 , Christian Jansen  1 , Joan Claria  4   5 , Jonel Trebicka  6   5
Affiliations
Comment

Hepatic inflammasome activation as origin of Interleukin-1α and Interleukin-1β in liver cirrhosis

Michael Praktiknjo et al. Gut. 2021 Sep.
No abstract available

Keywords: inflammation; liver cirrhosis.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
(A) Gene expression of interleukin (IL)-1α and (B) IL-1β in liver tissue and peripheral blood mononuclear cells (PBMC) in compensation (comp; left) and recompensation (recomp; right) model, as described in Monteiro et al. n=5 in all groups. **p<0.01 PBMC versus liver. (C) Serum concentrations of IL-1α and (D) IL-1β in portal venous compartment (black dots) and in hepatic venous compartment (gray dots) from patients with cirrhosis. n=27. *p<0.05 portal vein versus hepatic vein.
Figure 2
Figure 2
(A) Gene expression of interleukin (IL)-18 and (B) Gasdermin-D (GSDMD) in liver tissue from cirrhotic and non-cirrhotic control patients. (C) Protein levels of GSDMD and cleaved N-terminal GSDMD by Western Blot in liver tissue from cirrhotic and non-cirrhotic control patients. Controls (black dots), cirrhosis (gray dots). *p<0.05, **p<0.01, ***p<0.001 cirrhosis versus control.
See this image and copyright information in PMC

Comment on

References

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