Transplantation of stem cell-derived pancreatic islet cells

Giacomo Lanzoni^{1

2

3}, Camillo Ricordi^{4

5

6}

Affiliations

¹ Diabetes Research Institute and Cell Transplant Center, University of Miami Miller School of Medicine, Miami, FL, USA.
² Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA.
³ Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
⁴ Diabetes Research Institute and Cell Transplant Center, University of Miami Miller School of Medicine, Miami, FL, USA. ricordi@miami.edu.
⁵ Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA. ricordi@miami.edu.
⁶ Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA. ricordi@miami.edu.

Comment

Giacomo Lanzoni et al. Nat Rev Endocrinol. 2021 Jan.

. 2021 Jan;17(1):7-8.

doi: 10.1038/s41574-020-00430-9.

Giacomo Lanzoni^{1

2

3}, Camillo Ricordi^{4

5

6}

¹ Diabetes Research Institute and Cell Transplant Center, University of Miami Miller School of Medicine, Miami, FL, USA.
² Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA.
³ Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
⁴ Diabetes Research Institute and Cell Transplant Center, University of Miami Miller School of Medicine, Miami, FL, USA. ricordi@miami.edu.
⁵ Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA. ricordi@miami.edu.
⁶ Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA. ricordi@miami.edu.

No abstract available

Comment on

Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after Transplantation.
Augsornworawat P, Maxwell KG, Velazco-Cruz L, Millman JR. Augsornworawat P, et al. Cell Rep. 2020 Aug 25;32(8):108067. doi: 10.1016/j.celrep.2020.108067. Cell Rep. 2020. PMID: 32846125 Free PMC article.

1. National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes in America 3rd ed (NIH, 2018).
1. Augsornworawat, P., Maxwell, K. G., Velazco-Cruz, L. & Millman, J. R. Single-cell transcriptome profiling reveals beta cell maturation in stem cell-derived islets after transplantation. Cell Rep. 32, 108067 (2020). - DOI
1. Ricordi, C. et al. National Institutes of Health-sponsored clinical islet transplantation consortium phase 3 trial: manufacture of a complex cellular product at eight processing facilities. Diabetes 65, 3418–3428 (2016). - DOI
1. Lablanche, S. et al. Islet transplantation versus insulin therapy in patients with type 1 diabetes with severe hypoglycaemia or poorly controlled glycaemia after kidney transplantation (TRIMECO): a multicentre, randomised controlled trial. Lancet Diabetes Endocrinol. 6, 527–537 (2018). - DOI
1. Ricordi, C. et al. Transplanting islet cells can fix brittle diabetes. Why isn’t it available in the U.S.? CellR4 7, e2768 (2019).