Intraoperative radiotherapy for early breast cancer - insufficient evidence to change practice
- PMID: 33087894
- PMCID: PMC7576112
- DOI: 10.1038/s41571-020-00444-2
Intraoperative radiotherapy for early breast cancer - insufficient evidence to change practice
Abstract
We argue that the evidence remains insufficient for use of intraoperative radiotherapy (IORT) in women with early stage breast cancer outside of a clinical trial, as the recently reported TARGIT-A trial does not provide sufficient evidence to conclude that IORT is superior to no radiotherapy.
Conflict of interest statement
The authors declare no competing interests.
Comment in
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Reply to 'Intraoperative radiotherapy for breast cancer: powerful evidence to change practice'.Nat Rev Clin Oncol. 2021 Mar;18(3):188-189. doi: 10.1038/s41571-021-00472-6. Nat Rev Clin Oncol. 2021. PMID: 33495551 No abstract available.
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Intraoperative radiotherapy for breast cancer: powerful evidence to change practice.Nat Rev Clin Oncol. 2021 Mar;18(3):187-188. doi: 10.1038/s41571-021-00471-7. Nat Rev Clin Oncol. 2021. PMID: 33495552 Free PMC article. No abstract available.
Comment on
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Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial.BMJ. 2020 Aug 19;370:m2836. doi: 10.1136/bmj.m2836. BMJ. 2020. PMID: 32816842 Free PMC article. Clinical Trial.
References
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- Early Breast Cancer Trialists’ Collaborative. et al. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet. 2011;378:1707–1716. doi: 10.1016/S0140-6736(11)61629-2. - DOI - PMC - PubMed
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- Vaidya JS, et al. An international randomised controlled trial to compare TARGeted Intraoperative radioTherapy (TARGIT) with conventional postoperative radiotherapy after breast-conserving surgery for women with early-stage breast cancer (the TARGIT-A trial) Health Technol. Assess. 2016;20:1–188. doi: 10.3310/hta20730. - DOI - PMC - PubMed
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- Vaidya JS, et al. Effect of delayed targeted intraoperative radiotherapy vs whole-breast radiotherapy on local recurrence and survival: long-term results from the TARGIT-A randomized clinical trial in early breast cancer. JAMA Oncol. 2020;6:e200249. doi: 10.1001/jamaoncol.2020.0249. - DOI - PMC - PubMed
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