Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Dec;17(12):723-724.
doi: 10.1038/s41571-020-00444-2.

Intraoperative radiotherapy for early breast cancer - insufficient evidence to change practice

Affiliations
Comment

Intraoperative radiotherapy for early breast cancer - insufficient evidence to change practice

Peter D Sasieni et al. Nat Rev Clin Oncol. 2020 Dec.

Abstract

We argue that the evidence remains insufficient for use of intraoperative radiotherapy (IORT) in women with early stage breast cancer outside of a clinical trial, as the recently reported TARGIT-A trial does not provide sufficient evidence to conclude that IORT is superior to no radiotherapy.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Comment in

Comment on

References

    1. Vaidya JS, et al. Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial. BMJ. 2020;370:m2836. doi: 10.1136/bmj.m2836. - DOI - PMC - PubMed
    1. Correa C, et al. Accelerated partial breast irradiation: executive summary for the update of an ASTRO evidence-based consensus statement. Pract. Radiat. Oncol. 2017;7:73–79. doi: 10.1016/j.prro.2016.09.007. - DOI - PubMed
    1. Early Breast Cancer Trialists’ Collaborative. et al. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet. 2011;378:1707–1716. doi: 10.1016/S0140-6736(11)61629-2. - DOI - PMC - PubMed
    1. Vaidya JS, et al. An international randomised controlled trial to compare TARGeted Intraoperative radioTherapy (TARGIT) with conventional postoperative radiotherapy after breast-conserving surgery for women with early-stage breast cancer (the TARGIT-A trial) Health Technol. Assess. 2016;20:1–188. doi: 10.3310/hta20730. - DOI - PMC - PubMed
    1. Vaidya JS, et al. Effect of delayed targeted intraoperative radiotherapy vs whole-breast radiotherapy on local recurrence and survival: long-term results from the TARGIT-A randomized clinical trial in early breast cancer. JAMA Oncol. 2020;6:e200249. doi: 10.1001/jamaoncol.2020.0249. - DOI - PMC - PubMed