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Case Reports
. 2020 Sep 14;8(10):2013-2016.
doi: 10.1002/ccr3.3165. eCollection 2020 Oct.

Idiopathic hypereosinophilic syndrome: A rare diagnosis in children

Kristine Appel Uldall Pallesen  1 , Troels Herlin  2 , Mette Holm  2 , Christian Høst  2 , Mette Christiansen  3 , Mette Ramsing  4 , Mads Kirchheiner Rasmussen  1 , Mette Sommerlund  1
Affiliations
Case Reports

Idiopathic hypereosinophilic syndrome: A rare diagnosis in children

Kristine Appel Uldall Pallesen et al. Clin Case Rep. .

Abstract

Idiopathic hypereosinophilic syndrome (IHES) is one of numerous hypereosinophilic syndromes. The incidence of IHES among children is unknown, but it is considered a rare disease. We report a pediatric case of IHES and the challenges to finding an effective treatment. The patient described here was responsive to prednisolone and thalidomide.

Keywords: hypereosinophilia; idiopathic hypereosinophilic syndrome; prednisolone; thalidomide.

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Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of this paper.

Figures

FIGURE 1
FIGURE 1
A, Generalized dermatitis with papulonodular skin rash on the extensor side of extremities and trunk. B, Dermatitis with papulonodular skin rash on the hands and feet. C, Punch biopsy from lateral abdominal skin showing epidermal irregular acanthosis with superficial incrustation and a dermal perivascular and an interstitial mixed inflammatory infiltrate with lymphocytes, histiocytes, and eosinophils (HE ×400). Insert: Close‐up from mid dermis showing massive eosinophilia (HE ×4000)
See this image and copyright information in PMC

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