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. 2021 Feb 1;60(5):2594-2598.
doi: 10.1002/anie.202009842. Epub 2020 Dec 1.

A Tubular DNA Nanodevice as a siRNA/Chemo-Drug Co-delivery Vehicle for Combined Cancer Therapy

Zhaoran Wang  1   2 , Linlin Song  1 , Qing Liu  1 , Run Tian  1   2 , Yingxu Shang  1 , Fengsong Liu  1   2 , Shaoli Liu  1 , Shuai Zhao  1   2 , Zihong Han  1   2 , Jiashu Sun  1   2 , Qiao Jiang  1   2 , Baoquan Ding  1   2
Affiliations

A Tubular DNA Nanodevice as a siRNA/Chemo-Drug Co-delivery Vehicle for Combined Cancer Therapy

Zhaoran Wang et al. Angew Chem Int Ed Engl. .

Abstract

Using the DNA origami technique, we constructed a DNA nanodevice functionalized with small interfering RNA (siRNA) within its inner cavity and the chemotherapeutic drug doxorubicin (DOX), intercalated in the DNA duplexes. The incorporation of disulfide bonds allows the triggered mechanical opening and release of siRNA in response to intracellular glutathione (GSH) in tumors to knockdown genes key to cancer progression. Combining RNA interference and chemotherapy, the nanodevice induced potent cytotoxicity and tumor growth inhibition, without observable systematic toxicity. Given its autonomous behavior, exceptional designability, potent antitumor activity and marked biocompatibility, this DNA nanodevice represents a promising strategy for precise drug design for cancer therapy.

Keywords: DNA origami; cancer therapy; drug delivery; nanodevice; siRNA delivery.

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