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Review
. 2020 Oct 22;16(10):e1008905.
doi: 10.1371/journal.ppat.1008905. eCollection 2020 Oct.

Is antimicrobial resistance evolution accelerating?

Christopher Witzany  1 , Sebastian Bonhoeffer  2 , Jens Rolff  1   3
Affiliations
Review

Is antimicrobial resistance evolution accelerating?

Christopher Witzany et al. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1
Timeline of antibiotic (a) and antifungal (c) introduction and detection of surmised evolved resistance depicted by the ends of the bars. In antibiotics (b) and antifungals (d), the time to resistance decreases with the year of introduction: for newer antimicrobials, resistance is described earlier after introduction (linear regression for antibiotics (b) F1,16 = 6.47, p < 0.05*, R2 = 0.29 and antifungals (d) F1,13 = 19.57, p < 0.001***, R2 = 0.60).
Fig 2
Fig 2
Timeline of antifungal (a) introduction and detection of evolved resistance for antifungals where the source could be traced (unambiguous and reliable sources of data points are shown in blue; untraceable data are shown in red and excluded from analysis) (b). The time to resistance decreases with the year of introduction (linear regression F1,12 = 8.10, p < 0.05*, R2 = 0.40).
See this image and copyright information in PMC

References

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