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Clinical Trial
. 2020 Oct 22;20(1):251.
doi: 10.1186/s12893-020-00914-5.

Mesoglycan for pain control after open excisional HAEMOrrhoidectomy (MeHAEMO): an observational multicentre study on behalf of the Italian Society of Colorectal Surgery (SICCR)

G Gallo  1   2 , S Di Saverio  3 , G Clerico  4 , A Sturiale  5 , M Manigrasso  6 , A Realis Luc  4 , M Trompetto  4 , G Sammarco  7 ; MeHAEMO Working Group
Collaborators, Affiliations
Clinical Trial

Mesoglycan for pain control after open excisional HAEMOrrhoidectomy (MeHAEMO): an observational multicentre study on behalf of the Italian Society of Colorectal Surgery (SICCR)

G Gallo et al. BMC Surg. .

Erratum in

Abstract

Background: Excisional haemorrhoidectomy is the gold standard technique in patients with III and IV degree haemorrhoidal disease (HD). However, it is associated with a significant rate of post-operative pain. The aim of our study was to evaluate the efficacy of mesoglycan in the post-operative period of patients who underwent open excisional diathermy haemorrhoidectomy (OEH).

Methods: This was a retrospective multicentre observational study. Three hundred ninety-eight patients from sixteen colorectal referral centres who underwent OEH for III and IV HD were enrolled. All patients were followed-up on the first post-operative day (T1) and after 1 week (T2), 3 weeks (T3) and 6 weeks (T4). BMI, habits, SF-12 questionnaire, VAS at rest (VASs), after defecation (VASd), and after anorectal digital examination (VASe), bleeding and thrombosis, time to surgical wound healing and autonomy were evaluated.

Results: In the mesoglycan group, post-operative thrombosis was significantly reduced at T2 (p < 0.05) and T3 (p < 0.005), and all patients experienced less post-operative pain at each time point (p < 0.001 except for VASe T4 p = 0.003). There were no significant differences between the two groups regarding the time to surgical wound healing or post-operative bleeding. There was an early recovery of autonomy in the mesoglycan group in all three follow-up periods (T2 p = 0.016; T3 p = 0.002; T4 p = 0.007).

Conclusions: The use of mesoglycan led to a significant reduction in post-operative thrombosis and pain with consequent early resumption of autonomy. Trial registration NCT04481698-Mesoglycan for Pain Control After Open Excisional HAEMOrrhoidectomy (MeHAEMO) https://clinicaltrials.gov/ct2/show/NCT04481698?term=Mesoglycan+for+Pain+Control+After+Open+Excisional+HAEMOrrhoidectomy+%28MeHAEMO%29&draw=2&rank=1.

Keywords: Haemorrhoidal disease; Mesoglycan; Mucocutaneous bridges; Open excisional haemorrhoidectomy; Post-operative pain; Thrombosis.

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Conflict of interest statement

The Authors declare that they have no competing interests. The Authors alone are responsible for the content and writing of the paper.

Figures

Fig. 1
Fig. 1
Post-operative bleeding
Fig. 2
Fig. 2
Post-operative thrombosis
Fig. 3
Fig. 3
Boxplot representing the physical score (PCS) distribution of the SF-12 questionnaire
Fig. 4
Fig. 4
Boxplot representing the mental score (MCS) distribution of the SF-12 questionnaire
Fig. 5
Fig. 5
Wound healing
See this image and copyright information in PMC

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