CHAPIR, a master regulator of cardiac hypertrophy

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Andrew Robson. Nat Rev Cardiol. 2021 Jan.

. 2021 Jan;18(1):4.

doi: 10.1038/s41569-020-00470-8.

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The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N⁶-methyladenosine methylation of Parp10 mRNA.
Gao XQ, Zhang YH, Liu F, Ponnusamy M, Zhao XM, Zhou LY, Zhai M, Liu CY, Li XM, Wang M, Shan C, Shan PP, Wang Y, Dong YH, Qian LL, Yu T, Ju J, Wang T, Wang K, Chen XZ, Wang YH, Zhang J, Li PF, Wang K. Gao XQ, et al. Nat Cell Biol. 2020 Nov;22(11):1319-1331. doi: 10.1038/s41556-020-0576-y. Epub 2020 Oct 5. Nat Cell Biol. 2020. PMID: 33020597

1. Gao, X.-Q. et al. The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N⁶-methyladenosine methylation of Parp10 mRNA. Nat. Cell Biol. https://doi.org/10.1038/s41556-020-0576-y (2020) - DOI - PubMed - PMC