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Comparative Study
. 2020;37(1):2-7.
doi: 10.36141/svdld.v37i1.8775. Epub 2020 Mar 15.

Serum Amyloid A in lung transplantation

Lucia Vietri  1 , Elena Bargagli  1 , David Bennett  1 , Antonella Fossi  1 , Paolo Cameli  1 , Laura Bergantini  1 , Miriana d'Alessandro  1 , Piero Paladini  2 , Luca Luzzi  2 , Francesco Gentili  3 , Maria Antonietta Mazzei  1   2   3   4 , Donatella Spina  4 , Piersante Sestini  1 , Paola Rottoli  1
Affiliations
Comparative Study

Serum Amyloid A in lung transplantation

Lucia Vietri et al. Sarcoidosis Vasc Diffuse Lung Dis. 2020.

Abstract

Background: Serum Amyloid A (SAA) is an acute phase protein and we analyzed its concentrations in lung transplantated patients (LTX).

Methods: 26 LTX patients (58.6 ± 11 years) and 11 healthy controls (55 ± 11.3 years). Three groups of LTX patients: acute rejection (AR, 7) bronchiolitis obliterans syndrome (BOS, 3), acute infection (INF, 9) and stable patients (NEG, 7).

Results: In LTX patients SAA concentrations were significantly increased, particularly in AR and INF. In LTX-AR patients were observed a correlation between SAA levels and peripheral CD4+ lymphocyte percentage (r=0.9, p<0.01) and a reverse correlation with FVC percentages (r -0.94, p=0.01).

Conclusions: SAA may represent a potential biomarker of LTX acute complications, with a prognostic value in AR. (Sarcoidosis Vasc Diffuse Lung Dis 2020; 37 (1): 2-7).

Keywords: lung transplantation; serum amyloid A; serum biomarkers.

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Figures

Fig. 1.
Fig. 1.
Statistically significant differences found between serum levels of SAA in controls and in LTX patients with acute rejection (LTX AR) (p = 0.01), in patients with acute infection (LTX INF) (p = 0.01). No significant differences were found between the levels of SAA in LTX patients with CLAD and stable transplant patients (NEG) compared to healthy controls
Fig. 2.
Fig. 2.
Positive statistical correlation between SAA and Ferritin values in LTX patients (r 0.58, p = 0.008).
Fig. 3.
Fig. 3.
Positive correlation between SAA and LDL cholesterol (with LDL) in LTX patients (r 0.42, p = 0.06).
Fig. 4.
Fig. 4.
Negative statistical correlation between SAA and FVC (% of predicted) values in LTX patients with acute rejection (r -0.94, p = 0.01).
Fig. 5.
Fig. 5.
Graphical representation of the statistical correlation between SAA and CD4 + T lymphocytes of peripheral venous blood (lymphoid T CD4%) in lung transplanted patients with acute rejection (r 0.9, p = 0.01).
Fig. 6.
Fig. 6.
Kaplan-Meier curves for the comparison of survival time in a population of LTX patients, stratified according the 75° percentile of SAA levels.
See this image and copyright information in PMC

References

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