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. 2020;37(1):37-42.
doi: 10.36141/svdld.v37i1.7980. Epub 2020 Mar 15.

Interstitial lung disease and microscopic polyangiitis in chilean patients

Pamela Wurmann  1   2 , Francisca Sabugo  1   2 , Fabian Elgueta  1   2 , Macarena Mac-Namara  1   2 , Karen Vergara  1   2 , Daniela Vargas  1   2 , Maria Luisa Molina  1   2 , Juan Carlos Díaz  1   2 , Hector Gatica  1   2 , Annelise Goecke  1   2
Affiliations

Interstitial lung disease and microscopic polyangiitis in chilean patients

Pamela Wurmann et al. Sarcoidosis Vasc Diffuse Lung Dis. 2020.

Abstract

Objective: To describe the clinical and serological patients characteristics with Microscopic Polyangiitis (MPA) and Interstitial lung disease (ILD).

Methods: Of all the patients with AAV diagnosed between 2007-2017 at the Hospital Clinico Universidad de Chile, those with MPA and ILD were selected and studied retrospectively.

Results: All patients were Hispanic; median age at diagnosis 65 years (32-84). 59% were female. All were positive for p-ANCA, 16 patients for MPO. Most common manifestations were constitutional symptoms, weight loss and fever. CT-Scans patterns were Usual Interstitial Pneumonia (UIP) in 10 patients, Nonspecific Interstitial Pneumonia (NSIP) in 6 and fibrosis not UIP or NSIP pattern in 1. In 6 cases, ILD was diagnosed 0.5-14 years before MPA and concomitantly in 11.

Conclusions: Although infrequent, Microscopic Polyangiitis should be suspected in patients with ILD particularly if extra-pulmonary manifestations that rise the possibility of a systemic illness are present, regardless of the time elapsed between the latter and the diagnosis of this type of lung involvement. (Sarcoidosis Vasc Diffuse Lung Dis 2020; 37 (1): 37-42).

Keywords: ANCA vasculitis; interstitial lung disease; microscopic polyangiitis.

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