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Case Reports
. 2021 Jan 29;67(1):fmaa064.
doi: 10.1093/tropej/fmaa064.

Corynebacterium diphtheriae Infection in Mahajanga, Madagascar: First Case Report

Rivo Solotiana Rakotomalala  1 , Zo Zafitsara Andrianirina  2 , Elisoa Ratsima  3 , Patrick Randrianandraina  4 , Frédérique Randrianirina  3 , Glenn Torrencelli Edosoa  5 , Tahirimalala Rabenandrianina  1 , Edgar Badell  6   7 , Julie Toubiana  6   7   8 , Diavolana Andrianarimanana  2 , Sylvain Brisse  6   7 , Andry Rasamindrakotroka  9
Affiliations
Case Reports

Corynebacterium diphtheriae Infection in Mahajanga, Madagascar: First Case Report

Rivo Solotiana Rakotomalala et al. J Trop Pediatr. .

Abstract

Diphtheria is an infection that has been unreported for more than two decades in Mahajanga. A child, aged 4, presented with a pseudomembranous pharyngitis was associated with a dysphagia. He was from a rural municipality of Ambato Boeny at Mahajanga province and was admitted to the Pediatric Unit of the University Hospital Center. The child was not immunized against diphtheria. A throat swab was performed and cultured, from which Corynebacterium diphtheriae was identified. The strain, of biovar Mitis, was confirmed as diphtheria toxin (DT)-gene positive and produced DT (Elek test). Unfortunately, the child developed cardiac and neurological complications and died of respiratory and heart failure.

Keywords: Corynebacterium diphtheriae; diphtheria toxin; pharyngitis.

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