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Comment
. 2020 Nov 9;38(5):613-615.
doi: 10.1016/j.ccell.2020.10.014. Epub 2020 Oct 22.

Biologically Informed Neural Networks Predict Drug Responses

Casey S Greene  1 , James C Costello  2
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Biologically Informed Neural Networks Predict Drug Responses

Casey S Greene et al. Cancer Cell. .
Free article

Abstract

Deep neural networks often achieve high predictive accuracy on biological problems, but it can be hard to contextualize how and explain why predictions are made. In this issue, Kuenzi et al. model the sensitivity of cancers to drugs using deep neural networks with a hierarchical structure derived from the Gene Ontology.

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Conflict of interest statement

Declaration of Interests J.C.C. is a founder of PrecisionProfile, Inc., and has ownership in the company.

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