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Review
. 2020 Dec:132:110903.
doi: 10.1016/j.biopha.2020.110903. Epub 2020 Oct 20.

miR-1: A comprehensive review of its role in normal development and diverse disorders

Amin Safa  1 , Zahra Bahroudi  2 , Hamed Shoorei  3 , Jamal Majidpoor  4 , Atefe Abak  5 , Mohammad Taheri  6 , Soudeh Ghafouri-Fard  7
Affiliations
Free article
Review

miR-1: A comprehensive review of its role in normal development and diverse disorders

Amin Safa et al. Biomed Pharmacother. 2020 Dec.
Free article

Abstract

MicroRNA-1 (miR-1) is a conserved miRNA with high expression in the muscle tissues. In humans, two discrete genes, MIRN1-1 and MIRN1-2 residing on a genomic region on 18q11.2 produce a single mature miRNA which has 21 nucleotides. miR-1 has a regulatory role on a number of genes including heat shock protein 60 (HSP60), Kruppel-like factor 4 (KLF4) and Heart And Neural Crest Derivatives Expressed 2 (HAND2). miR-1 has critical roles in the physiological processes in the smooth and skeletal muscles as well as other tissues, thus being involved in the pathogenesis of a wide range of disorders. Moreover, dysregulation of miR-1 has been noted in diverse types of cancers including gastric, colorectal, breast, prostate and lung cancer. In the current review, we provide the summary of the data regarding the role of this miRNA in the normal development and the pathogenic processes.

Keywords: Development; Muscle; Tumor; miR-1.

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