Orchestrated freedom: new insights into cortical neurogenesis

Abstract

In mammals, the construction of the cerebral cortex involves the coordinated output of large populations of apical progenitor cells. Cortical progenitor cells use intrinsic molecular programs and complex regulatory mechanisms to generate a large diversity of excitatory projection neurons in appropriate numbers. In this review, we summarize recent findings regarding the neurogenic behavior of cortical progenitors during neurogenesis. We describe alternative models explaining the generation of neuronal diversity among excitatory projection neurons and the role of intrinsic and extrinsic signals in the modulation of the individual output of apical progenitor cells.