Ageing is associated with increased variability of cellular reprogramming and wound healing

Constanze Schmidt^{1

2

3}, Stefan M Kallenberger^{4

5}

Affiliations

¹ Department of Cardiology, University of Heidelberg, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, D-69120 Heidelberg, Germany.
² DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, University of Heidelberg, Heidelberg, Germany.
³ HCR, Heidelberg Center for Heart Rhythm Disorders, University of Heidelberg, Heidelberg, Germany.
⁴ Digital Health Center, Berlin Institute of Health (BIH) and Charité, Berlin 10178, Germany.
⁵ Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.

Comment

Constanze Schmidt et al. Cardiovasc Res. 2020.

. 2020 Nov 1;116(13):e171-e174.

doi: 10.1093/cvr/cvaa294.

Constanze Schmidt^{1

2

3}, Stefan M Kallenberger^{4

5}

¹ Department of Cardiology, University of Heidelberg, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, D-69120 Heidelberg, Germany.
² DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, University of Heidelberg, Heidelberg, Germany.
³ HCR, Heidelberg Center for Heart Rhythm Disorders, University of Heidelberg, Heidelberg, Germany.
⁴ Digital Health Center, Berlin Institute of Health (BIH) and Charité, Berlin 10178, Germany.
⁵ Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.

No abstract available

Keywords: Ageing; Fibroblasts; Regenerative medicine; Wound healing; Induced pluripotent stem cells.

Comment on

Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing.
Mahmoudi S, Mancini E, Xu L, Moore A, Jahanbani F, Hebestreit K, Srinivasan R, Li X, Devarajan K, Prélot L, Ang CE, Shibuya Y, Benayoun BA, Chang ALS, Wernig M, Wysocka J, Longaker MT, Snyder MP, Brunet A. Mahmoudi S, et al. Nature. 2019 Oct;574(7779):553-558. doi: 10.1038/s41586-019-1658-5. Epub 2019 Oct 23. Nature. 2019. PMID: 31645721 Free PMC article.