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. 1987 Oct;329(6140):599-604.
doi: 10.1038/329599a0.

HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

J A Todd  1 , J I Bell, H O McDevitt
Affiliations

HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

J A Todd et al. Nature. 1987 Oct.

Abstract

Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease susceptibility and resistance, and that the structure of the DQ molecule, in particular residue 57 of the beta-chain, specifies the autoimmune response against the insulin-producing islet cells.

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