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Review
. 2020 Oct 21;9(10):3381.
doi: 10.3390/jcm9103381.

Use of Sublingual Immunotherapy for Aeroallergens in Children with Asthma

Carlo Caffarelli  1 , Carla Mastrorilli  2 , Michela Procaccianti  1 , Angelica Santoro  1
Affiliations
Review

Use of Sublingual Immunotherapy for Aeroallergens in Children with Asthma

Carlo Caffarelli et al. J Clin Med. .

Abstract

Asthma is a heterogeneous disease that in children is often allergen-driven with a type 2 inflammation. Sublingual immunotherapy represents an important progress in the use of personalized medicine in children with allergic asthma. It is a viable option for house dust mite-driven asthma and in subjects with the asthma associated with allergic rhinitis. The use and indications for isolated asthma caused by other allergens are still controversial owing to heterogeneity of commercially available products and methodological limitations of studies in children. Nevertheless, most studies and meta-analyses found the efficacy of sublingual immunotherapy. Sublingual immunotherapy is safe but cannot be recommended in children with uncontrolled asthma.

Keywords: asthma; children; efficacy; house dust mite; pollen allergy; rhinitis; safety; sublingual immunotherapy.

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Conflict of interest statement

The authors declare no conflict of interest.

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