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Case Reports
. 2020 Oct 23;20(1):386.
doi: 10.1186/s12883-020-01962-3.

Case report: anti-N-Methyl-D-Aspartate receptor encephalitis and bilateral temporal calcifications

Yujie Bu  1 , Tinghua Zhang  1 , Jia Guo  2
Affiliations
Case Reports

Case report: anti-N-Methyl-D-Aspartate receptor encephalitis and bilateral temporal calcifications

Yujie Bu et al. BMC Neurol. .

Abstract

Background: In this study, we report a case of a young female who was hospitalized for seizures and diagnosed with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis.

Case presentation: The main feature of this patient was bilateral temporal calcifications detected by routine head computed tomography (CT). The co-existence of anti-NMDAR encephalitis and cerebral calcifications has not been reported. We supposed that the patient had an incomplete form of celiac disease (CD), epilepsy and cerebral calcifications syndrome (CEC). The patient's symptoms were alleviated by a series of treatments, and she remained stable during the follow-ups.

Conclusions: Our findings confirm the rarity co-existing anti-NMDAR encephalitis and cerebral calcifications. In future clinical work, we need to elucidate the relationship between anti-NMDAR encephalitis and cerebral calcifications, and the association between anti-NMDAR encephalitis and other co-existing autoimmune disorders.

Keywords: Anti-NMDAR encephalitis; Bilateral temporal calcifications; CEC; Epilepsy.

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Conflict of interest statement

None of the authors declared any conflict of interest.

Figures

Fig. 1
Fig. 1
Plain computed tomography of the brain at presentation to the hospital showing patchy calcification in bilateral temporal cortico-subcortical areas (left > right)
Fig. 2
Fig. 2
T2 fluid-attenuated inversion recovery (FLAIR) axial views showing obvious hyperintense signals and mild swilling in bilateral parietal-occipital lobe, temporal lobe and insular cortex
Fig. 3
Fig. 3
Plain computed tomography of the brain at third admission showing calcifications in bilateral temporal corticosubcortical areas were increased
See this image and copyright information in PMC

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