Brain Mural Cells Express CAR T-cell Target
- PMID: 33097477
- DOI: 10.1158/2159-8290.CD-NB2020-095
Brain Mural Cells Express CAR T-cell Target
Abstract
Evidence continues to grow that KRAS, once considered an "undruggable" target, can be targeted successfully in non-small cell lung cancer. In a phase I trial, the KRASG12C inhibitor sotorasib elicited responses in about a third of patients with the disease and was generally well tolerated.
©2020 American Association for Cancer Research.
Comment on
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Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies.Cell. 2020 Oct 1;183(1):126-142.e17. doi: 10.1016/j.cell.2020.08.022. Epub 2020 Sep 21. Cell. 2020. PMID: 32961131 Free PMC article.
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