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Meta-Analysis
. 2021 Jan;303(1):47-53.
doi: 10.1007/s00404-020-05840-8. Epub 2020 Oct 23.

Prevalence of adenomyosis in endometrial cancer patients: a systematic review and meta-analysis

Antonio Raffone  1 , Renato Seracchioli  2 , Diego Raimondo  3 , Manuela Maletta  2 , Antonio Travaglino  4 , Ivano Raimondo  5   6 , Ilaria Giaquinto  2 , Benedetta Orsini  2 , Luigi Insabato  4 , Massimiliano Pellicano  1 , Fulvio Zullo  1
Affiliations
Meta-Analysis

Prevalence of adenomyosis in endometrial cancer patients: a systematic review and meta-analysis

Antonio Raffone et al. Arch Gynecol Obstet. 2021 Jan.

Abstract

Introduction: Several studies have assessed the histological co-existence of endometrial carcinoma (EC) and adenomyosis. However, the significance of this association is still unclear.

Objective: To assess the prevalence of adenomyosis in women with EC for a better understanding of the association between the two diseases.

Materials and methods: A systematic review and meta-analysis was performed by searching electronics databases from their inception to March 2020, for all studies that allowed extraction of data about prevalence of adenomyosis in EC patients. Adenomyosis prevalence was calculated for each included study and as pooled estimate, with 95% confidence interval (CI).

Results: Eight retrospective cohort studies assessing 5573 EC patients were included in our analysis. Of total, 1322 were patients with adenomyosis, and 4251 were patients without adenomyosis. Pooled prevalence of adenomyosis in EC patients was 22.6% (95% CI 12.7-37.1%).

Conclusion: Adenomyosis prevalence in EC patients was not different from that reported for other gynecological conditions. The supposed association between the two diseases appears unsupported.

Keywords: Endometrium; Gynecology; Malignancy; Myometrium; Oncology; Tumor.

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Conflict of interest statement

The authors report no conflict of interest.

Figures

Fig. 1
Fig. 1
Flow diagram of studies identified in the systematic review [Prisma template (Preferred Reporting Item for Systematic Reviews and Meta-analyses)]
Fig. 2
Fig. 2
Forest plot of prevalence of adenomyosis in patients with endometrial cancer, for each included study and as pooled estimate
Fig. 3
Fig. 3
Assessment of risk of bias. Summary of risk of bias for each study; Plus sign: low risk of bias; minus sign: high risk of bias; question mark: unclear risk of bias
Fig. 4
Fig. 4
Risk of bias graph about each risk of bias item presented as percentages across all included studies
Fig. 5
Fig. 5
Funnel plot for the assessment of the risk of bias across studies, reporting logit adenomyosis rate on the x axis and the standard error on the y axis
See this image and copyright information in PMC

Comment in

  • A tricky case of endometrial cancer arising from adenomyosis.
    Paris V, Cola E, Santoni M, Pioli F, Piermartiri MG, Orici F, Pelagalli M. Paris V, et al. Eur J Obstet Gynecol Reprod Biol. 2023 Jun;285:212-213. doi: 10.1016/j.ejogrb.2023.04.013. Epub 2023 Apr 19. Eur J Obstet Gynecol Reprod Biol. 2023. PMID: 37127477 No abstract available.

References

    1. Struble J, Shannon R, Mohamed A. Adenomyosis: a clinical review of a challenging gynecologic condition. J Minim Invasive Gynecol. 2016;23(2):164–185. doi: 10.1016/j.jmig.2015.09.018. - DOI - PubMed
    1. Bergeron C, Amant F, Ferenczy A. Pathology and physiopathology of adenomyosis. Best Pract Res Clin Obstet Gynaecol. 2006;20(4):511–521. doi: 10.1016/j.bpobgyn.2006.01.016. - DOI - PubMed
    1. Garcia L, Isaacson K. Adenomyosis: review of the literature. J Minim Invasive Gynecol. 2011;18(4):428–437. doi: 10.1016/j.jmig.2011.04.004. - DOI - PubMed
    1. Di Donato N, Montanari G, Benfenati A, et al. Do women with endometriosis have to worry about sex? Eur J Obstet Gynecol Reprod Biol. 2014;179:69–74. doi: 10.1016/j.ejogrb.2014.05.022. - DOI - PubMed
    1. Alabiso G, Alio L, Arena S, et al. Adenomyosis: what the Patient Needs. Endometriosis Treatment Italian Club. J Minim Invasive Gynecol. 2016;23(4):476–488. doi: 10.1016/j.jmig.2015.12.017. - DOI - PubMed

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