Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jan 1;36(1):42-59.
doi: 10.1093/ndt/gfaa192.

European Consensus Statement on the diagnosis and management of osteoporosis in chronic kidney disease stages G4-G5D

Pieter Evenepoel  1 , John Cunningham  2 , Serge Ferrari  3 , Mathias Haarhaus  4   5 , Muhammad Kassim Javaid  6 , Marie-Hélène Lafage-Proust  7 , Daniel Prieto-Alhambra  8 , Pablo Ureña Torres  9   10 , Jorge Cannata-Andia  11 ; European Renal Osteodystrophy (EUROD) workgroup, an initiative of the CKD-MBD working group of the ERA-EDTA, and the committee of Scientific Advisors and National Societies of the IOF
Collaborators, Affiliations
Review

European Consensus Statement on the diagnosis and management of osteoporosis in chronic kidney disease stages G4-G5D

Pieter Evenepoel et al. Nephrol Dial Transplant. .

Abstract

Controlling the excessive fracture burden in patients with chronic kidney disease (CKD) Stages G4-G5D remains an impressive challenge. The reasons are 2-fold. First, the pathophysiology of bone fragility in patients with CKD G4-G5D is complex and multifaceted, comprising a mixture of age-related (primary male/postmenopausal), drug-induced and CKD-related bone abnormalities. Second, our current armamentarium of osteoporosis medications has not been developed for, or adequately studied in patients with CKD G4-G5D, partly related to difficulties in diagnosing osteoporosis in this specific setting and fear of complications. Doubts about the optimal diagnostic and therapeutic approach fuel inertia in daily clinical practice. The scope of the present consensus paper is to review and update the assessment and diagnosis of osteoporosis in patients with CKD G4-G5D and to discuss the therapeutic interventions available and the manner in which these can be used to develop management strategies for the prevention of fragility fracture. As such, it aims to stimulate a cohesive approach to the management of osteoporosis in patients with CKD G4-G5D to replace current variations in care and treatment nihilism.

Keywords: CKD-MBD; bone mineral density; chronic renal insufficiency; mineral metabolism; renal osteodystrophy.

PubMed Disclaimer

Publication types