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Meta-Analysis
. 2021 Mar;28(3):1041-1055.
doi: 10.1111/ene.14607. Epub 2020 Dec 1.

Biological fluid levels of iron and iron-related proteins in Parkinson's disease: Review and meta-analysis

Félix Javier Jiménez-Jiménez  1 , Hortensia Alonso-Navarro  1 , Elena García-Martín  2 , José A G Agúndez  2
Affiliations
Meta-Analysis

Biological fluid levels of iron and iron-related proteins in Parkinson's disease: Review and meta-analysis

Félix Javier Jiménez-Jiménez et al. Eur J Neurol. 2021 Mar.

Abstract

Background and purpose: Several studies suggested a role or iron in the pathogenesis or Parkinson's disease (PD), and substantia nigra iron concentrarions have been found increased in PD. However, the results on cerebrospinal (CSF) and serum/plasma iron levels in PD patients have been controversial. The aim of this systematic review and meta-analysis was to establish the CSF and serum/plasma levels of iron and iron-related proteins (ferritin, transferrin, lactoferrin, haptoglobin, and hepcidine) levels, and the urine levels of iron, in patients with PD.

Methods: Four databases (PubMed, EMBASE, MedLine, and Web of Science - Core Collection) were reviewed for studies published from 1966 to October 5, 2020. References of interest were identified. A meta-analysis of eligible studies was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) and Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines, using the R software package meta.

Results: A non-significant trend towards higher CSF iron levels and marginally significantly lower serum/plasma iron levels was observed in patients with PD compared with age- and sex-matched controls. CSF and serum/plasma ferritin and transferrin concentrations, and serum/plasma lactoferrin and haptoglobin concentrations did not differ significantly between PD patients and controls.

Conclusion: The findings of this study suggest an association between decreased serum/plasma iron levels and, possibly, higher CSF iron levels with risk of PD.

Keywords: Parkinson's disease; cerebrospinal fluid; ferritin; iron; serum/plasma; transferrin; urine.

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References

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